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概要と使いどころ
Trace every user-facing button/touchpoint through its full state change sequence to find bugs where functions individually work but cancel each other out, produce wrong final state, or leave the UI in an inconsistent state. Use when: systematic debugging found no bugs but users report broken buttons, or after any major refactor touching shared state stores.
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Use Mermaid diagrams in DecisionsAI to explain technical topics — architecture, flows, sequences, and data models via the freestanding diagram viewer.
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Run Karpathy-style autoresearch optimization on any content. Generates 50+ variants, scores with a 5-expert simulated panel, evolves winners through multiple rounds, outputs optimized version + full experiment log. Use when optimizing landing pages, email sequences, ad copy, headlines, form pages, CTA text, or any conversion-focused content. Triggers on "optimize this page", "run autoresearch", "score these variants", "A/B test this copy".
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Auto-assembles a domain-specific expert panel (7–10 experts), scores any content or strategy artifact against a typed rubric, and iterates until the aggregate hits 90+ (max 3 rounds). Use as a quality gate on copy, email sequences, landing-page drafts, strategy docs, charts, titles, or recruiting evaluations — or when another skill needs a final review gate on its output. Triggers on "expert panel this", "score this", "rate these variants", "quality check this", "panel review", "expert score", "evaluate this copy/strategy/page". For variant generation and multi-round conversion optimization see autoresearch; for live-URL CRO auditing see conversion-ops; for the scripted content-production pipeline see content-pipeline.
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name: advisory-committee description: "4-agent AI advisory committee for strategic decisions. Runs CS, Marketing, Finance, and Tech agents in sequence to analyze proposals and deliver a majority-vo...
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Multi-channel ABM automation that turns LinkedIn URLs into coordinated outbound campaigns. Scrapes profiles, enriches with Apollo (email + phone), gets mailing addresses via Skip Trace, then orchestrates email sequences, LinkedIn touches, and handwritten letters via Scribeless. The secret weapon for standing out in crowded inboxes.
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Comprehensive guide for creating software diagrams using Mermaid syntax. Use when users need to create, visualize, or document software through diagrams including class diagrams (domain modeling, object-oriented design), sequence diagrams (application flows, API interactions, code execution), flowcharts (processes, algorithms, user journeys), entity relationship diagrams (database schemas), C4 architecture diagrams (system context, containers, components), state diagrams, git graphs, pie charts, gantt charts, or any other diagram type. Triggers include requests to "diagram", "visualize", "model", "map out", "show the flow", or when explaining system architecture, database design, code structure, or user/application flows.
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Council — 5 independent AI perspectives + mutual critique + synthesis (adapted from karpathy/llm-council for Claude Code). For high-stakes decisions where the answer does NOT follow unambiguously from the data — go/no-go before real consequences, critiquing a methodology, choosing between competing approaches, pressure-testing a conclusion you're attached to, designing risk controls. NOT for log/data analysis (the council has no data access) and not for factual lookups. Triggers — "convene the council", "run it past the council", "go/no-go", "pressure-test this".
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Safe deployment workflow for Drupal 10/11 sites: pre-flight checks, backup, the correct update sequence (composer install, database updates, config import, cache rebuild), verification, and rollback plan. Use when deploying to any environment, releasing to production, or when the user asks to "push changes live", "update the server", or run a release. Also use for multisite releases where each site needs its own database update pass.
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Produces structured U.S. legal audit summaries that distill compliance findings into executive-ready risk prioritization and remediation plans, covering likelihood/impact scoring, consequence analysis, and corrective actions with timelines and owners. Use for legal audits, compliance audits, regulatory audits, compliance gap analyses, risk assessments, audit report summaries, or remediation roadmaps. Trigger keywords: audit summary, compliance findings, audit report, risk prioritization, remediation plan, regulatory exposure, corrective action plan.
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Generate publish-grade SVG+PNG technical diagrams (architecture, data flow, sequence, ER, state-machine, etc.) in 8 styles. Writes to tasks/visuals/. Needs rsvg-convert for PNG; else SVG-only.
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Create inline Mermaid v11 diagrams -- flowcharts, sequence, class, ER, Gantt, state, timeline, and more -- for markdown and browser. Zero deps; mmdc optional for CLI export.
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Create diagrams and visualizations using Mermaid.js v11 syntax. Use when generating flowcharts, sequence diagrams, class diagrams, state diagrams, ER diagrams, Gantt charts, user journeys, timelines, architecture diagrams, or any of 24+ diagram types. Supports JavaScript API integration, CLI rendering to SVG/PNG/PDF, theming, configuration, and accessibility features. Essential for documentation, technical diagrams, project planning, system architecture, and visual communication.
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Call this skill when faced with "wicked problems", complex challenges, or when a user asks for strategic innovation, root-cause analysis, or long-term problem solving. Do not use for simple, linear tasks. This skill forces the agent to bypass superficial symptoms, map the entire ecosystem, and anticipate second-order consequences before proposing an intervention.
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Apply normative BDI reasoning to agents that must detect norms, choose which commitments to internalize, and resolve conflicts by comparing consequences. Use when obligations, prohibitions, or policies collide in autonomous systems. NOT for simple fixed-priority rules, pure constraint satisfaction, or domains where no real normative conflict exists.
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Visualises RNA-modification data with transcript-feature metagene plots (Guitar GuitarPlot; MetaPlotR; deepTools computeMatrix scale-regions), peak-centred heatmaps (ComplexHeatmap; deepTools plotHeatmap), IP-vs-input paired browser tracks (log2 IP/input bigWig via deepTools bamCompare; pyGenomeTracks; Gviz; IGV/UCSC track hubs), DRACH sequence-logo plots (ggseqlogo; MEME), feature-distribution stacked bars, and volcano/MA plots for differential modification. Establishes stop-codon enrichment in the metagene plot as the biological QC anchor for any MeRIP dataset (Dominissini 2012; Meyer 2012). Use when producing the canonical metagene plot with stop-codon enrichment as a QC anchor, building paired IP/input genome-browser tracks at single-locus resolution, plotting peak-centred heatmaps clustered by condition, summarising peak distribution across transcript features, generating DRACH motif logos as sanity checks, rendering volcano plots of differential m6A, or reproducing the stop-codon enrichment plot.
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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
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Assigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme churn (V3/V4/V4.1/V5.3.2/Midnight) with dropout regions, and recombinant X-prefix designation lag. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater into lineage frequencies with Freyja, tracking lineage frequencies over time, handling ARTIC primer dropouts, or running surveillance for SARS-CoV-2/influenza/Mpox/RSV/H5N1/measles.
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Convert between sequence file formats (FASTA, FASTQ, GenBank, EMBL, Stockholm) and re-encode FASTQ quality offsets using Biopython Bio.SeqIO. Use when changing a file format for a downstream tool, fixing FASTQ quality encoding (Phred+33 vs Phred+64 vs Solexa), or when a conversion risks silently dropping annotations or quality scores.
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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.
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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.
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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.
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Retrieve records from NCBI databases using Biopython Bio.Entrez (EFetch, ESummary). Use when downloading sequences, fetching GenBank/GenPept records, getting document summaries, parsing nested XML, navigating GI deprecation, choosing between rettype+retmode combinations, and parsing into Biopython SeqRecord/SwissProt objects. Covers nucleotide, protein, gene, pubmed, sra, gds, taxonomy, snp, clinvar.
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Analyze codon usage and calculate CAI (Codon Adaptation Index), RSCU, and Nc with Biopython, and produce naive max-CAI codon-optimized sequences. Use when scoring a gene's codon bias against a host, optimizing a CDS for heterologous expression, or studying synonymous codon selection.
日本語の概要は準備中です。原文の説明を表示しています。