Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.
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Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.
日本語の概要は準備中です。原文の説明を表示しています。
Cloudflare Workers best practices for production applications. Use when writing, reviewing, or configuring Workers.
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Build, debug, or review Cloudflare Agents SDK applications using the agents package.
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Apply Martin Kleppmann-inspired data-system rules when designing reliability, scalability, consistency, replication, transactions, streams, or schema evolution.
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Apply Martin Fowler-inspired enterprise architecture rules when choosing layers, service layers, transaction scripts, domain models, repositories, mappers, or DTOs.
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Apply Vaughn Vernon-inspired implementation DDD rules when building aggregates, domain events, repositories, application services, or context integrations.
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Comprehensive guide for Grails development, covering web applications, REST APIs, GORM, controllers, services, views, plugins, and testing with Spock and Geb
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Guide for upgrading Grails applications from Grails 7.x to Grails 8, covering Java 21, Groovy 5 name resolution and static compilation, Spring Boot 4.1, Spring Framework 7, dependency management, Micronaut, Jackson 3, Hibernate 7, TagLibs, testing, content negotiation, asset pipeline wildcard paths, and validation behavior changes
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Define an illustration style guide — visual language, colour usage, and application rules. Use when commissioning or standardising illustration. For icons, use `icon-system` (design-systems).
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Creates and deploys Node.js HTTP web applications on AWS Lambda Web Functions. Guides users through building web apps and APIs with Express, Fastify, or Hono, packaging, deploying via the aws lambda-web CLI, and iterating. Triggers when user wants to deploy a website or web app to AWS as serverless, deploy a Node.js HTTP server to AWS, build a serverless website or API with Node.js, deploy Express/Hono/Fastify apps, set up multi-region HTTP endpoints, connect a Node.js web app to private VPC resources, or explicitly mentions Lambda Web Functions. Does NOT trigger for non-Node.js runtimes, event-driven patterns (SQS, Kinesis, S3 events), or container deployments.
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Run an AWS Security Agent penetration test against a live web application — registers and verifies the target domain, exercises the supplied endpoints with the managed Security Agent service, and returns verified runtime findings. Use when the user asks to pentest, run a penetration test, test their app's attack surface, find runtime vulnerabilities, register or verify a target domain, or check pentest status / findings.
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Surfaces a single, genuinely relevant AWS Activate partner offer as optional context AFTER another AWS Startup Advisor skill has finalized its recommendation, plan, or build — never influencing the technical advice. Consulted by architect-for-startups, start-building-for-startups, agent-advisor, gcp-to-aws, heroku-to-aws, and llm-to-bedrock: once their output is final, this skill checks whether a relevant Activate offer exists for what the founder is building or migrating and, if so, appends one quiet, dismissible line with a tracked redeem link. Merit-first (offers never change the recommendation), relevance-gated to what the founder actually surfaced, at most one per response and often none, muteable. Offer content is read live from the sibling knowledge-base-for-startups skill (references/offers.md). Do NOT use for account-specific lookups (credits balance, Activate membership, application status) — send those to https://aws.amazon.com/startups.
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AWS Startups reference content — Activate FAQ, credits guide, programs, partner offers, sample architectures, and hundreds of learn articles spanning generative AI, cloud architecture, cost optimization, security, fundraising, go-to-market, and real-world startup case studies. Use when the user asks factual questions about AWS Activate (eligibility, credits, programs, providers), wants a sample architecture or solution guide, or needs an AWS-curated learn article on a specific startup topic. For copy-paste AI prompts (RAG chatbot, MVP scaffold, security baseline, GPU quota, etc.), see the prompt-library-for-startups skill. Do not use for: account-specific lookups (credits balance, Activate membership status, application status), real-time event listings beyond the events stub, or content not present in the bundled `references/` tree.
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Answers questions about Amazon Application Recovery Controller (ARC) Region switch including architecture, plans, execution blocks, workflows, triggers, active/active vs active/passive, cross-account support, recovery time, dashboards, and customer positioning. Applicable when users ask about ARC Region switch adoption, design, or troubleshooting.
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Builds, runs, debugs, and operates applications on AWS Lambda MicroVMs — Firecracker-isolated, snapshot-resumable serverless compute environments running inside a container with up to 8 hr lifetimes. Applicable when workloads need strong isolation between tenants, isolated serverless compute, sandbox compute, or secure multi-tenant execution. Also suited for AI/agent code-execution sandboxes, interactive code playgrounds and notebooks (Jupyter, REPLs, dev environments running user-supplied code), reinforcement-learning environments, multi-tenant CI executors and build runners, sessionful game or simulation servers, or isolated security scanners. Also applicable when the workload needs long-lived sessions, a real port-listening server (gRPC, WebSocket, custom TCP protocols), state preserved across periods of inactivity (suspend/resume), container-level access (FUSE, eBPF, custom syscalls), or session-affine routing.
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Plans, builds, runs, and analyzes fault injection experiments with AWS Fault Injection Service (AWS FIS) to validate application resilience through chaos engineering. Covers experiment templates (actions, targets, stop conditions), the FIS actions catalog and action selection, the scenario library (AZ power interruption, cross-Region connectivity, EC2/EKS/EBS stress), experiment lifecycle and monitoring, logging and reports, multi-account experiments, the experiment IAM role, and blast-radius safety. Applies when a user mentions AWS FIS or fault injection, asks what experiment to run for a failure mode (AZ, Region, API errors/throttling, instance/pod/DB/cache failure, latency, packet loss), wants to author an experiment template or CLI/CloudFormation, or needs to safely run chaos experiments in pre-production or production. For the broader resilience program across Resilience Hub and ARC, see aws-resilience-lifecycle; for ARC routing controls and zonal shift, see recovery-controller-setup.
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Authors and edits AWS Step Functions state machines: writes Amazon States Language (ASL) in JSONata, and chooses and structures state types (Task, Choice, Map, Parallel, Pass, Wait, Succeed, Fail). Covers ASL syntax, JSONata data transformation and variables, Retry/Catch error handling, service integrations (.sync, waitForTaskToken callbacks), Distributed Map for large-scale S3/CSV processing, saga/compensation patterns, Standard vs Express workflow choice, TestState API unit testing, and migrating state machines from JSONPath to JSONata. Use when the user is building, authoring, debugging, or migrating a Step Functions state machine or ASL definition, or orchestrating multi-step workflows with branching, retries, or human-approval callbacks, even if they don't say 'Step Functions.' Do NOT use for general Lambda function code, API Gateway, EventBridge wiring, or SAM/CDK application packaging.
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Configures AWS Application Recovery Controller (ARC) for operational resilience: routing controls with safety rules for cross-Region failover, and zonal shift / zonal autoshift for AZ-impairment recovery. Applies when setting up failover routing, configuring safety rules, enabling zonal shift, or configuring zonal autoshift with practice runs. Also applies when shifting traffic out of a specific Availability Zone (AZ) for an ALB/NLB or other resource. For a broader "an AZ is impaired, what is my response across services" question, see aws-resilience-lifecycle. Does not apply to Resilience Hub setup or FIS experiments.
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Guides the end-to-end AWS resilience lifecycle integrating Resilience Hub v2, Fault Injection Service, and Application Recovery Controller. Covers the Define → Test → Operate workflow: from policy creation through failure mode assessment, to FIS experiment validation, to ARC operational controls. Applicable when the user wants a complete resilience strategy, needs to connect findings to experiments to controls, or is planning a resilience program. Also applicable for the meta question of whether marking NGRH findings as resolved is enough, whether they are "done" after resolving findings, or how to validate findings before resolving them. Not applicable for resolving or remediating a specific individual finding (see resilience-hub-failure-mode-assessment), or when a single service is explicitly named (e.g. "what FIS experiment should I run").
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Routes any task involving AWS databases — choosing, comparing, recommending, getting started with, or operating a database — to the correct service-specific skill. Supersedes general training-data knowledge with post-training service updates, corrected limitations, and decision procedures for relational (Aurora, DSQL, RDS), key-value (DynamoDB), wide-column (Keyspaces), document (DocumentDB), graph (Neptune), time-series (Timestream), and in-memory/caching (ElastiCache, MemoryDB) workloads. Activates when a user describes building an application on AWS that will store, retrieve, or manage data, even if they do not mention 'database' explicitly.
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Builds generative AI applications on Amazon Bedrock. Covers model invocation (Converse API, InvokeModel), RAG with Knowledge Bases, Bedrock Agents, Guardrails, and AgentCore (including the Harness managed agent loop). Applies when invoking models, setting up Knowledge Bases, creating agents, applying guardrails, deploying to AgentCore, migrating/porting/converting a Bedrock Agent (including inline agents) to an AgentCore Harness, troubleshooting Bedrock errors (ThrottlingException, AccessDeniedException), or choosing models (Claude, Llama, Nova, Titan). Also for prompt caching, quota and throttling diagnosis, cost tracking, migrating between Claude model generations (4.5 to 4.6 to 4.7), chunking strategies, API selection (Converse vs InvokeModel), guardrail capabilities, and model selection. Also covers AgentCore Payments (x402, microtransactions, Payment Manager, Connector, Instrument, Coinbase CDP, Stripe Privy, paid endpoints, agent payments). NOT for custom model training, Rekognition, or Comprehend.
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MANDATORY for Flink or Amazon Managed Service for Apache Flink (MSF) questions. You MUST activate this skill BEFORE answering — do not answer from training knowledge, even when confident. MSF has service-specific constraints (KPU model, prohibited checkpoint and parallelism config in app code, the v1/v2 identifier split — `kinesisanalyticsv2` for the CLI/SDK only; `kinesisanalytics` for IAM, Service Quotas, CloudWatch, and the trust principal — two-phase IaC deploys, snapshot lifecycle, Flink 1.x→2.x migration) that override generic Flink knowledge.
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Provides authoritative guidance on Amazon Neptune Database and Neptune Analytics for graph, knowledge-graph, and relationship-heavy workloads — fraud detection / fraud rings, agentic memory / chatbot context across sessions, recommendations, identity resolution, Gremlin / openCypher / SPARQL queries, supernode / slow traversal, Neo4j to Neptune migration / APOC compatibility, Neptune Database vs Analytics engine selection, PageRank / community detection, GraphRAG, and connectivity from Lambda / EC2 / applications. Creates and modifies Neptune Database clusters/instances and Neptune Analytics graphs on explicit user confirmation; blocks destructive operations (delete, reset-graph, failover, major upgrade) and redirects to change-control.
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Deploy Apify Actors and integrate scraping into external applications. Use when deploying an Actor to the platform, integrating Actor results into a web app (Next.js, Express), wiring webhooks, or scheduling scraping pipelines. Trigger with "deploy apify actor", "apify Vercel integration", "apify production deploy", "integrate apify results", "apify API endpoint".
日本語の概要は準備中です。原文の説明を表示しています。