「dpo」の検索結果

Generate production-ready API documentation from endpoint descriptions. Outputs OpenAPI 3.0, markdown reference docs, and SDK quickstart guides.

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Install, configure, and manage 1-SEC — an open-source, all-in-one cybersecurity platform (16 modules, single binary) on Linux servers and VPS instances. Use when the user asks to secure a server, install security monitoring, set up intrusion detection, harden a VPS, protect an AI agent host, or deploy endpoint defense. Covers installation, setup, enforcement presets, module configuration, alert management, and ongoing security operations.

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Design, implement, or review dygo HTTP APIs and public App SDK contracts. Use for Record APIs, metadata and boot endpoints, query behavior, response envelopes, compatibility, and public Go interfaces.

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Guides stable API and interface design. Use when designing APIs, module boundaries, or any public interface. Use when creating REST or GraphQL endpoints, defining type contracts between modules, or establishing boundaries between frontend and backend.

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Use this skill when running local AI models with Docker Model Runner — the `docker model` CLI — e.g. "run an LLM locally with Docker", "pull a model from the ai/ namespace", "connect my app to a local model", "use a local model as backend for the Drupal AI module", or when wiring the `models:` top-level element into a compose.yaml. Covers pulling/running models, OpenAI-compatible endpoints, and Compose integration.

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Scope, preregister, execute, audit, normalize, and publish GEODE evaluations with research-question, reproduction, attempt-lineage, trajectory, verifier-receipt, and immutable artifact contracts. Use for benchmark runs or comparisons, eval-artifact and cache-accounting audits, GPT or subscription result normalization, research question or hypothesis framing, retry diagnosis, trajectory publication, DPO or reward-data readiness reviews, and requests involving MCPMark, tau2, BFCL, Agent-World, HAL, Terminal-Bench, or Toolathlon.

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Generate API endpoint with route, controller, validation, and tests

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审计网站是否符合阿塞拜疆《个人数据法》（Law on Personal Data No. 998-IIIQ），并在适用时符合欧盟 GDPR 以及 ePrivacy/饼干同意规则。盘点存在的隐私文件（隐私政策、饼干政策、饼干横幅、同意流程、控制者和 DPO 联系方式、数据主体权利渠道、跨境转移披露、AZ 运营者登记引用），并对照适用的法定要求逐项评分。产出双层报告：面向企业主的通俗语言红绿灯摘要，外加面向律师的逐条款发现表（带条款级引用）。仅评估 — 不起草。每当用户分享针对阿塞拜疆或面向阿塞拜疆网站的 URL 或隐私/饼干政策文本时使用；当用户提及 .az 域名、Law 998、AZ 国家登记簿、ePrivacy、第 27 条欧盟代表，或询问"is my site GDPR compliant"、"do I need to register as an operator in Azerbaijan"或"is our cookie banner lawful"时也使用 — 即使没有"audit"一词。

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Design and implement backend changes end to end: endpoints, handlers, services, integrations, webhooks, jobs, authenticated access. Routes contracts to api-design-principles, schema to database.

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Design and review durable REST, GraphQL, RPC, or event-facing API contracts. Use for public or shared API contracts, endpoint/schema consistency, compatibility, pagination, error semantics, and API documentation. Discovers existing consumers and conventions before recommending a style.

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DraftForge test infrastructure for writing backend unit tests, Playwright E2E tests, and managing test data population. This skill should be used when writing new tests, adding test fixtures, creating populate functions for new features, adding Playwright E2E specs, using login/auth fixtures, creating test users/orgs/leagues/tournaments, or understanding the test data architecture. Covers backend Django tests via Docker, Playwright config (projects, workers, sharding), test auth endpoints that expose backend login to frontend, and feature-isolated test data patterns.

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Use when CPU usage is high, memory grows unboundedly, goroutines leak, mutex contention shows in traces, or escape analysis suggests excess heap allocation. Triggers: net/http/pprof endpoint exposure, go tool pprof analysis, flamegraph generation, allocs vs inuse_space heap profiles, runtime/trace event timeline, mutex profiling, block profiling, goroutine dumps, GC pressure measurement. NOT for non-Go languages, distributed tracing (use OpenTelemetry skill), or production telemetry pipelines.

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Diagnose and eliminate the GraphQL N+1 resolver explosion using Facebook DataLoader's per-request batching, plus the second-order defenses (persisted queries, depth limits, cost analysis). Use when a GraphQL query that returns N items in a list triggers N+1 database round trips, when designing nested resolvers that load associations, when a list query times out under load, or when you need to budget query cost before resolvers run. NOT for REST-style endpoint design (use api-versioning-strategy), generic database query optimization (use database-query-optimizer), or schema design (use graphql-server-architect).

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Expert API designer for REST, GraphQL, gRPC architectures. Activate on: API design, REST API, GraphQL schema, gRPC service, OpenAPI, Swagger, API versioning, endpoint design, rate limiting, OAuth flow. NOT for: database schema (use data-pipeline-engineer), frontend consumption (use web-design-expert), deployment (use devops-automator).

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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.

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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.

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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

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Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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