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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

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ChIP-seq quality control metrics including FRiP (Fraction of Reads in Peaks), cross-correlation analysis (NSC/RSC), library complexity, and IDR (Irreproducibility Discovery Rate) for replicate concordance. Use to assess experiment quality before downstream analysis. Use when assessing ChIP-seq data quality metrics.

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Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.

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Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.

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Search scientific papers and retrieve structured experimental data extracted from full-text studies via the BGPT MCP server. Returns 25+ fields per paper including methods, results, sample sizes, quality scores, and conclusions. Use for literature reviews, evidence synthesis, and finding experimental details not available in abstracts alone.

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Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity. Use when assessing ATAC-seq library quality before or after peak calling to identify problematic samples.

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Autonomously screen NYSE, Nasdaq, and NYSE American operating-company stocks for undervalued-growth/GARP opportunities using forward same-basis valuation, driver-derived EPS/FCF forecasts, primary-source financial verification, SBC and dilution controls, sector and cycle normalization, auditable candidate-pool coverage, and fail-closed final reporting. Use when asked to find, screen, rank, or refresh US undervalued-growth stocks, including minimal requests with no ticker list or parameters.

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Comprehensive US stock analysis including fundamental analysis (financial metrics, business quality, valuation), technical analysis (indicators, chart patterns, support/resistance), stock comparisons, and investment report generation. Use when user requests analysis of US stock tickers (e.g., "analyze AAPL", "compare TSLA vs NVDA", "give me a report on Microsoft"), evaluation of financial metrics, technical chart analysis, or investment recommendations for American stocks.

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Configures and runs agents with different adapters including Claude, OpenAI, CrewAI, Lyzr, and GitHub Models. Supports local execution, remote git repos, and one-shot prompts. Use when the user wants to run an agent, switch LLM providers, configure adapter settings, or launch agents from git repositories.

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Use when the user asks to "launch on Product Hunt / Hacker News", "prepare community or directory launch submissions", or "plan the launch submission waves"; produces per-platform submission packages — a Product Hunt tagline / gallery / first-comment skeleton, a factual Show HN title and text, per-subreddit posts with a self-promotion rules table, tiered directory waves, and a regional channel matrix including Chinese communities — plus a platform red-line check (never solicit votes or organize voting rings) and T-0 submission-status lines for the launch registry. Not for paid amplification — use content-amplifier; not for creator channels — use campaign-planner; not for launch telemetry readouts — use launch-monitor; not for ongoing community presence or pre-launch karma-building outside the launch window — use participation-warmup-planner. 社区发布/PH提交包/Show HN/目录波次/平台红线/中文渠道

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Use when the user asks to "track rankings" or "查排名"; measures keyword and SERP-position deltas over time from provided exports or connected tools, including AI-response checks. Not for multi-metric stakeholder reports or setting alerts — use performance-monitor (report or alert mode). 排名追踪/SERP监控

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Use when the user asks to "map our positioning", "name our competitive alternatives", or "pick a beachhead segment for the launch"; produces a Dunford-style positioning canvas — named competitive alternatives (including spreadsheet and status quo), unique attributes (verifiable, or routed to the claims ledger), value themes (attribute→benefit→value chains), a target beachhead segment scored on serviceability / pain intensity / reachability, and a one-sentence onlyness statement — the sole upstream of the message house and the entity-signal source for the canonical entity profile. Not for the message house or per-channel launch copy — use message-house-builder; not for audience/persona profiling itself — use audience-mapper; not for SEO keyword positioning — use keyword-research. 定位画布/竞争替代品/独特价值/滩头细分

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Guide for developing on the Java 21 baseline, including modern features, best practices, and integration with Groovy/Grails projects

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Diagnoses and resolves Amazon EFS issues including mount failures, NFS timeouts, permission errors, throughput problems, and burst credit exhaustion. Use when the user has an EFS file system that is not mounting, returning errors, performing slowly, or showing access denied.

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Diagnoses and resolves Amazon S3 Files issues including mount failures, permission errors, synchronization problems, and performance issues. Use when the user has an S3 file system that is not mounting, returning access denied, not syncing changes to S3, showing files in lost+found, or performing slower than expected.

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Enables Redshift system-table (SYS_*) log publishing to S3 Tables in Apache Iceberg format for both Provisioned clusters and Serverless namespaces, verifies publishing status, and queries the published logs via any Iceberg-compatible engine including Redshift and Athena. Covers system tables such as sys_query_history, sys_query_text, sys_connection_log, sys_query_detail, and sys_session_history. Applies when turning on S3 Tables log publishing for a cluster or namespace, confirming publishing status and locating the S3 Tables namespace, querying non-realtime data from Redshift system tables off-cluster at scale, or building dashboards for Redshift monitoring and auditing, especially for historical or high-volume system-table data beyond the in-cluster SYS_ view retention window. Trigger phrases: publish redshift system table log to s3 tables, enable-logging s3 tables, describe redshift logging status, query redshift system tables in athena or redshift, redshift log exports to iceberg.

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Use when THIS agent needs to pay for x402-protected content at runtime: hitting a paywall mid-task, settling it via AgentCore Payments, and applying operator-defined spend limits. Covers payment setup, policy, session budgets, and troubleshooting. Triggers on: "my agent hit a 402 while calling an API", "a tool call returned 402 Payment Required", "my agent needs to pay for x402-protected content", "let the agent pay for content, capped at $5 per session", "set a spend limit for the agent", "ProcessPayment failed", or "why did my agent refuse to pay". Not for BUILDING payment capability for end users, including wallets and framework middleware; use agents-build and references/payments.md. For non-paid APIs via Gateway use agents-connect. For inbound auth use agents-harden. For project scaffolding use agents-get-started.

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Creates a production-ready VPC with public and private subnets across multiple Availability Zones, including internet gateway, NAT gateways, route tables, and security groups following AWS Well-Architected principles. Use when deploying multi-AZ VPC infrastructure with automatic CIDR planning and DNS resolution.

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Answers questions about Amazon Application Recovery Controller (ARC) Region switch including architecture, plans, execution blocks, workflows, triggers, active/active vs active/passive, cross-account support, recovery time, dashboards, and customer positioning. Applicable when users ask about ARC Region switch adoption, design, or troubleshooting.

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Evaluates, configures, and migrates workloads to AWS Lambda Managed Instances (LMI). Runs Lambda Event Functions (standard Lambda) on EC2 instances in the user's account while AWS manages provisioning, patching, scaling, routing, and load balancing. Triggers when queries mention Lambda Managed Instances, LMI, capacity providers, multi-concurrent execution environments, EC2-backed Lambda, persistent Lambda instances, PerExecutionEnvironmentMaxConcurrency, CapacityProviderConfig, cold start elimination via dedicated instances, migrating Lambda Event Functions to managed instances, or cost comparison between Lambda Event Functions and LMI with Savings Plans or Reserved Instances. Also covers long-running and asynchronous workloads and the 90-minute (5400s) function timeout for asynchronous and event-source-mapping (SQS, Kinesis, DynamoDB Streams / ESM) invocations, including how to raise the function timeout up to 90 minutes / 5400s and the related duration limits.

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Diagnoses and resolves Amazon RDS for Oracle connectivity, authentication, networking, and driver troubleshooting. Applicable to any RDS-for-Oracle question including connecting a Python Lambda to RDS Oracle in a VPC with pooling and cold-start optimization, EKS pods to RDS Oracle via the Secrets Manager CSI driver with IRSA and SecretProviderClass, ORA-12170 cross-VPC timeouts from EC2, DPI-1047 cannot-locate-64-bit-Oracle-Client errors, and Oracle Connection Manager (CMAN) on EC2 as a proxy with HA across two AZs. Covers python-oracledb thin vs thick mode, init_oracle_client, RDS Proxy does NOT support RDS Oracle, port 1521, VPC peering, Transit Gateway, Kerberos with AWS Managed Microsoft AD, SSL/TLS/NNE, SSM port forwarding, EC2/ECS Fargate/EKS/Lambda, SQL Developer/DBeaver/Toad/SQLcl, and Secrets Manager.

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Advises on Amazon RDS open-source engines (MySQL, MariaDB, PostgreSQL) for instance creation, upgrade planning, commitment pricing, proxy evaluation, and Blue/Green deployments. Handles any RDS MySQL, MariaDB, or PostgreSQL question, including create a production-ready RDS MySQL instance, provision an RDS PostgreSQL database, run the RDS upgrade advisor for my RDS MySQL instance, what are my upgrade options, upgrade RDS MariaDB from 10.6 to the latest version, should I buy reserved instances or a savings plan for db.r7g.2xlarge RDS MySQL, change a VARCHAR to INT column on RDS MySQL 8.0 with Blue/Green, and does RDS Proxy help when PgBouncer already runs in transaction mode. Covers instance creation with production best practices, describe-db-instances and describe-db-engine-versions upgrade-target workflow, live prechecks via SSM or direct connection, RI versus DSP commitment pricing, RDS Proxy versus PgBouncer, and Blue/Green lifecycle with binlog replay compatibility.

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Retrieves authoritative guidance on Amazon Timestream for InfluxDB across its supported engine variants. Applicable to any InfluxDB-on-AWS request including engine variant and licensing selection, provisioning and IAM, encryption at rest (AWS-owned and customer-managed KMS keys, key policies, and key lifecycle), schema design (tags vs fields, cardinality, HTTP/sensor/metric data modeling), migration from LiveAnalytics, Processing Engine plugins, connectivity (database endpoints and private or public access), and write/query errors.

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Launches an EC2 instance with secure, cost-efficient defaults including AMI selection, burstable instance sizing, least-privilege IAM roles, hardened security groups, encrypted EBS volumes, and comprehensive tagging. Use when deploying new EC2 instances following AWS best practices for security and cost optimization.

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