「nct」の検索結果

Extends a mechanistic or association-level biomedical finding into a staged validation pathway that moves from descriptive evidence toward stronger functional support, mechanistic specificity, and clinical relevance. Use this skill when a user has a pathway, biomarker, cell-state, target, mechanism, or association finding and needs to decide what should be validated next, in what order, and which evidence layers are necessary versus optional. Do not default to maximal validation stacks. Build a structured validation ladder with a primary route, stronger upgrade route, and optional extensions.

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Designs internal, external, temporal, and functional validation strategies at the protocol stage for medical research studies.

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Designs QTL colocalization studies that connect eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS loci. Always use this skill whenever a user wants to plan, scope, or structure a locus-level study asking whether a GWAS association and a molecular QTL association may reflect the same underlying causal signal. Covers locus definition, QTL/GWAS source architecture, ancestry and LD alignment, single-locus vs multi-locus strategy, candidate-gene prioritization, optional fine-mapping, linked MR/SMR follow-up, and functional annotation. Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, evidence hierarchy, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references. Never equate colocalization with causality proof, mediation proof, or automatic target validation. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets, repositories, consortia, or public resources.

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Generates complete conventional single-gene oncology research designs from a user-provided cancer context, target gene, and validation direction. Use when a study centers on a fixed candidate gene and needs expression, prognosis, clinicopathologic association, functional interpretation, immune context, genomic or epigenetic context, optional drug-response hypotheses, and orthogonal validation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, or applications. Generates creative, polished code that avoids generic AI aesthetics.

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Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.

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Apply when designing types, reviewing a function signature, or writing code in any statically-typed language. Make illegal states unrepresentable, brand semantic primitives, parse external data at boundaries, refuse to lie to the compiler, exhaust variants, derive from authoritative schemas.

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Apply when wiring validation, error handling, or framework adapters. Concentrate guards at system boundaries (CLI, config, network, external APIs); trust internal types and keep business logic in pure functions.

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Apply when you write, change, or keep a test. Call the code as its users do and assert the exact result they see. Rewrite or delete a test that would pass if every imported function returned undefined.

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Define custom distance/similarity metrics for clustering and ML algorithms. Use when working with DBSCAN, sklearn, or scipy distance functions with application-specific metrics.

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Generator economic dispatch and cost optimization for power systems. Use when minimizing generation costs, computing optimal generator setpoints, calculating operating margins, or working with generator cost functions.

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Guidance for analyzing network packet captures (PCAP files) and computing network statistics using Python, with tested utility functions.

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Reference for the TRL (Transformer Reinforcement Learning) library codebase. Use proactively before reading or editing any file under `trl/` so you have the intended contracts and invariants in mind, not just what the current code says. Covers trainer hierarchy (SFT, DPO, GRPO, KTO), shared utility functions (selective_log_softmax, decode_and_strip_padding, padding helpers), configuration system, model wrappers, and how data flows through any TRL trainer.

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An overview of the python package for running the GaMMA earthquake phase association algorithm. The algorithm expects phase picks data and station data as input and produces (through unsupervised clustering) earthquake events with source information like earthquake location, origin time and magnitude. The skill explains commonly used functions and the expected input/output format.

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Run Python code on cloud GPUs using Modal serverless platform. Use when you need A100/T4/A10G GPU access for training ML models. Covers Modal app setup, GPU selection, data downloading inside functions, and result handling.

日本語の概要は準備中です。原文の説明を表示しています。

Use when starting any creative work - creating features, building components, adding functionality, or modifying behavior. Explores user intent, requirements and design before implementation.

日本語の概要は準備中です。原文の説明を表示しています。

Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

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Use when the user asks to run heavy or GPU work on Modal (the cloud compute platform) — writing a Modal function in the workspace, running it with the user's own `modal` CLI + token, and bringing results back. Data-to-compute for jobs too big for the laptop, without a Slurm cluster.

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Upgrade an existing website or app to premium quality without breaking functionality — audit the current design, identify generic/AI tells, then apply taste and system rules surgically. Use when the user wants to improve, modernize, polish, or "make better" an existing UI/codebase.

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Master enterprise-grade Scala development with functional programming, distributed systems, and big data processing. Expert in Apache Pekko, Akka, Spark, ZIO/Cats Effect, and reactive architectures. Use PROACTIVELY for Scala system design, performance optimization, or enterprise integration.

日本語の概要は準備中です。原文の説明を表示しています。

Expert Haskell engineer specializing in advanced type systems, pure functional design, and high-reliability software. Use PROACTIVELY for type-level programming, concurrency, and architecture guidance.

日本語の概要は準備中です。原文の説明を表示しています。

Expert C4 Code-level documentation specialist. Analyzes code directories to create comprehensive C4 code-level documentation including function signatures, arguments, dependencies, and code structure. Use when documenting code at the lowest C4 level for individual directories and code modules.

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Dialogue writing and revision for screen and stage (对白/台词/潜台词) — merged from Robert McKee's Dialogue (dialogue as action, said/unsaid/unsayable, exposition as ammunition, beat = action/reaction gerunds, flaws of credibility/language/content/design, character-specific vocabulary and grammar, seven scene analyses), Richard Walter (economy, subtext, argument, no small talk, no parentheticals, silence), Neill Hicks (listening, on-the-nose exceptions, energy, five-step exercise), Lu Jun (语言要美; 典雅美/通俗美, 对话三要求 动作性/性格化/潜台词), Lajos Egri (dialogue born of three-dimensional character, escalation), Blake Snyder (cover-the-names test), and screwball-comedy dialogue conventions. Use when writing or polishing dialogue, fixing on-the-nose or expository lines, giving each character a distinct voice, converting a two-hander into a trialogue, writing comedy exchanges, or cutting speeches. Chinese-opera lyrics (戏曲唱词) are in sw-chinese-opera-banqiang, not here.

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Scaffolds React Native libraries with create-react-native-library for standalone libraries or local native modules and views. Use when creating or working on React Native libraries or adding native functionality in an existing app.

日本語の概要は準備中です。原文の説明を表示しています。