「proto」の検索結果

Think and work like an expert Carbon Cycle Scientist. Use when a task calls for Carbon Cycle Scientist judgment. Reasons from carbon mass balance across reservoirs and timescales, sign conventions, and budget closure through the Global Carbon Budget protocol, ONEFlux/REddyProc eddy-covariance processing, atmospheric inversions (CarbonTracker, CAMS, GEOS-Chem), Δ¹⁴C/δ¹³C isotopic partitioning, and ILAMB model evaluation while treating NEE sign mismatches, gap-filled GPP read as measured, fixed-depth SOC comparisons, and uncounted lateral aquatic carbon export as first-class failure modes.

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Think and work like an expert Comparative Medicine Researcher. Use when a task calls for Comparative Medicine Researcher judgment. Reasons from species biology, translational validity, and the 3Rs through model-validity frameworks, IACUC protocols, ARRIVE 2.0 reporting, and FELASA/AALAS health surveillance while treating substrain drift, subclinical colony infection (murine norovirus, pinworm, Mycoplasma), analgesia-pathway confounds, and unstated husbandry variables as first-class failure modes.

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Think and work like an expert Anesthesiologist. Use when a task calls for Anesthesiologist judgment. Reasons from control of consciousness, analgesia, autonomic response, and oxygen delivery through the ASA Difficult Airway Algorithm, capnography and arterial-waveform trends, quantitative TOF monitoring, and ASRA/ERAS protocols while treating cannot-ventilate airways, local anesthetic systemic toxicity, malignant hyperthermia, and residual neuromuscular blockade as first-class failure modes.

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SwiftUI frontend visual design skill. Creates beautiful, distinctive iOS/macOS interfaces that avoid generic AI slop patterns. Covers design direction, layout systems, typography, color, spacing, brand integration, and design review. Use when designing new SwiftUI views, reviewing UI quality, creating iOS prototypes, choosing visual styles, improving app aesthetics, or when the UI looks generic or AI-generated.

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Institutional-grade equity research skills for AI agents. 80 Claude-type skills across 14 verticals (equity-research-core, models-and-pitches, bio-pharm, scenarios, quantitative-analysis, idea-generation, options-derivatives, business-intelligence, industry-analysis, macro-strategy, portfolio-strategy, technical-analysis, risk-and-psychology, trading-as-business) powered by agentii.ai's agent-use-ready SEC filing data plane — SEC filings and 15K+ earnings call transcripts, 15.99M XBRL facts, and company profiles for 1,146+ US-public-equity tickers. Features the three-layer retrieval protocol (Document Discovery → Page Map → Deep Read, with deep-outline escalation) — measured, not asserted: 97.5% saved against a sequential read, and the page map itself is 10.0% of one (spec 062 T030, 2026-09-23) — server-side parallel multi-period search via search_cross_period, a full Excel/PPT generation pipeline with 3-tier office backend support, and the spec-046 governance layer (constitution, thesis and single-skill modes, mechanical gates, and a template-owned disclaimer on generated reports).

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Manage the operational learnings lifecycle — load prior learnings to inform current work, harvest new patterns worth preserving, and keep the document tight over time. Provides a protocol for accumulating actionable patterns from practice that complement standards and defaults. Use when a workflow session completes and produced insights worth persisting, when starting a session that should benefit from prior patterns, or when the user says 'harvest learnings', 'what have we learned', 'capture this pattern', 'tighten learnings', 'compress learnings', or 'operational learnings'.

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Protocol for handling ambiguous decisions and missing/conflicting knowledge during code generation, design, and review. Ensures AI surfaces genuine judgment calls with structured options and stops on hallucination risk instead of silently assuming. Use when a decision has multiple valid approaches, when facts are missing or contradictory, when the user asks 'what should we do here?', 'is this a judgment call?', 'should I ask about this?', 'am I guessing here?', 'what are the tradeoffs?', or when deciding between two reasonable architectural or design options. Also composed by molecules to define how judgment calls and clarification requests are surfaced and resolved.

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Local and self-hosted text-to-speech with Kokoro, the ~82M-parameter open-weight (Apache 2.0) model by hexgrad. Use when synthesizing speech offline, on-device, in the browser, or on your own server without per-character API cost — for high-volume narration, audiobooks, privacy-constrained pipelines, and prototyping. Covers running Kokoro via the Python `kokoro` package, ONNX / kokoro-js in the browser, and the OpenAI-compatible Kokoro-FastAPI wrapper; picking voices and language codes; blending voices; chunking long text; controlling pronunciation via misaki/espeak-ng; and judging when Kokoro is the right tool versus when its lack of voice cloning, narrow emotional range, and weaker non-English quality mean you should reach for a hosted or larger model instead. Not for voice cloning, expressive/emotional character performance, or high-fidelity multilingual work — say so and route elsewhere.

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End-to-end CLIP-seq pipeline from FASTQ to ENCODE-compliant binding sites, single-nucleotide crosslink maps, annotation, motifs, and (optionally) differential binding. Use when running the full Yeo lab eCLIP / iCLIP / iCLIP2 / iCLIP3 / irCLIP / PAR-CLIP analysis with SMInput control, protocol-specific UMI extraction, ENCODE STAR parameters, CLIPper or Skipper peak calling with stringent log2 FC and -log10 p thresholds, IDR rescue and self-consistency QC, and downstream motif registration with mCross or PEKA.

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Preprocess CLIP-seq reads (eCLIP, iCLIP, iCLIP2, iCLIP3, irCLIP, PAR-CLIP, FLASH) with protocol-specific UMI extraction, adapter trimming, length filtering, and post-alignment PCR-duplicate collapse. Use when raw CLIP FASTQ must be turned into deduplicated, crosslink-preserving BAM input for peak calling; choosing between two-pass and single-pass adapter trimming; deciding minimum read length; or mapping UMI patterns to specific eCLIP/iCLIP/iCLIP2/iCLIP3 library preps.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.

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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

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Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

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Creates new Source of Truth (SoT) files when existing templates don't fit your needs. Triggers on requests to create a new SoT file, add a new artifact type, or when user says "I need to track [X] but there's no SoT for it", "create SoT", "new source of truth". Outputs a properly structured SoT.*.md file with ID prefix, frontmatter, and update protocol.

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Write and maintain high-quality Swift DocC documentation for the TMDb package, following its established `///` conventions. Use when adding or changing any public declaration (protocol, class, struct, enum, actor, model, property, initializer, method, typealias) and when keeping the DocC catalog in sync. This is the single source of truth for the project's documentation style — applied inline as you write, and followed by the `documentation-writer` agent for bulk sweeps.

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Apply when facing a novel UI interaction or architectural decision with no precedent in the codebase. Build 2-3 competing prototypes and compare side by side before committing.

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Apply when refactoring, evaluating diff size, or tempted to add abstractions, layers, or signal threading. Bias toward deletion and the smallest change that solves the problem.

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You are an expert in Bolt.new by StackBlitz, the AI-powered full-stack development environment that runs entirely in the browser. You help developers go from idea to deployed app in minutes using natural language prompts — Bolt generates complete applications with frontend, backend, database, and deployment, all running in a WebContainer without local setup.

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Use Amazon SNS for pub/sub messaging and notifications. Create topics and manage subscriptions across protocols (SQS, Lambda, HTTP, email, SMS). Configure message filtering, mobile push notifications, and fan-out architectures.

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Appium is an open-source framework that automates native, hybrid and mobile-web apps on iOS and Android through the WebDriver protocol. Use when the user wants to set up Appium 3, write mobile UI tests in JavaScript (WebdriverIO) or Python, pick capabilities, run gestures, or fix "appium", "XCUITest", "UiAutomator2", "mobile automation" problems. For React Native-only testing, see detox.

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You are an expert in amqplib, the Node.js client for RabbitMQ and AMQP 0-9-1 protocol. You help developers implement reliable message queuing with work queues, pub/sub fanout, topic routing, RPC patterns, dead letter queues, and message acknowledgment — building decoupled microservices that communicate asynchronously through RabbitMQ.

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Expert in building custom tools that solve your own problems first. The best products often start as personal tools - scratch your own itch, build for yourself, then discover others have the same itch. Covers rapid prototyping, local-first apps, CLI tools, scripts that grow into products, and the art of dogfooding. Use when "build a tool, personal tool, scratch my itch, solve my problem, CLI tool, local app, automate my, build for myself, " mentioned.

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Patterns for laboratory automation including liquid handling robotics, LIMS integration, protocol development, quality control, and high-throughput workflows. Covers both open-source (Opentrons) and commercial platforms. Use when ", " mentioned.

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