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Evidence-based medical knowledge and research mentor grounded in the Bian Que tradition. Covers clinical reasoning, diagnostic thinking (望闻问切), pharmacology, pathology, differential diagnosis, medical literature appraisal, and the philosophy of early intervention. Trigger whenever users ask about medicine, clinical science, drugs, disease mechanisms, diagnosis, lab interpretation, treatment comparison, or health sciences. Even without explicit research framing, trigger on any topic touching disease, therapeutics, or clinical decision-making. Part of the AIPOCH Medical Research Skill Hub.

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Organizes the evidence and competitive landscape around a drug, target, or pathway by separating disease relevance, tractability, preclinical evidence, clinical evidence, modality fit, and crowding. Always map what is biologically supported, what is druggable, what has actually advanced, and what remains strategically open. Never confuse target relevance with druggability, preclinical activity with clinical promise, or narrative excitement with validated development maturity. Never fabricate references, trial status, approval status, company activity, or asset metadata.

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Use when generating Sankey or alluvial plots from sample annotation tables where rows are samples and selected columns are categorical stages such as risk group, response status, subtype, or cohort labels. NOT for: gene network flow analysis, continuous-value trajectories, or graph-structured pathway visualization.

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Reverse-engineers the methods section of a biomedical paper into a structured, reproducible workflow. Use this skill when a user wants to understand how a study was actually executed, extract data sources, inclusion/exclusion logic, preprocessing, analytical sequence, software/tools, validation path, and critical parameters, or build a replication checklist from a paper, abstract, DOI, PMID, title, screenshot, or partial methods text. Do not treat this as generic summarization. Focus on reconstructing the operational method pipeline, surfacing missing reproducibility details, and distinguishing explicitly reported steps from inferred or unresolved ones. Never fabricate references, methods details, identifiers, software versions, parameters, datasets, or validation steps.

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Detects methodological gaps across study design, analysis, validation, bias control, reproducibility, and implementation readiness within a biomedical research area. Use this skill when a user wants to identify what current studies are still methodologically missing, which weaknesses are most consequential, and what upgrade path would produce a stronger next-step study. Always separate design gaps, analysis gaps, validation gaps, and reproducibility gaps. Never treat technical complexity as methodological rigor.

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Identifies translationally meaningful paths for bioinformatics findings by mapping omics or computational discoveries to diagnosis, stratification, prognosis, treatment-response, monitoring, or target-nomination use cases, while auditing bridge evidence, assayability, and validation burden. Use this skill when a user wants to know whether a bioinformatics finding can be framed as a stronger translational topic without overclaiming clinical relevance. Always separate statistical signal from translational value, and never imply clinical utility, targetability, or validation depth without explicit evidence support.

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Systematically maps mechanism evidence for a disease from molecules to pathways, cell types, tissues, biological consequences, and clinical phenotypes. Always use this skill when a user needs a layered mechanism evidence chain rather than a flat summary or immediate gap analysis. Formal literature citations must be real and verifiable.

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Use when building a binary classification model from an expression matrix or other omics feature matrix with LASSO logistic regression, cross-validation, and coefficient path visualization. NOT for: multiclass classification, survival/Cox models, or ordinary linear regression.

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Use when selecting predictive genes or other molecular features from bulk expression matrices for binary case-vs-control classification with elastic net logistic regression, including coefficient path and cross-validation plots. Trigger keywords: elastic net, glmnet, feature selection, binary classification, lambda.min, lambda.1se. NOT for: survival/Cox modeling, multiclass outcomes, single-cell data, or non-expression tables.

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Use when profiling CPU/memory hot paths, generating flame graphs, or capturing JFR/perf evidence.

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Identifies external providers, merchants, nonprofits, platforms, APIs, and software services, and resolves the documented way to engage them — to pay, donate, subscribe, book, provision, or integrate with them. MUST be used BEFORE web search, model memory, or any other directory/vendor-lookup skill for ANY request that requires selecting, finding, or engaging an external provider or organization — whether a specific one is named ("pay my Twilio bill"), implied ("donate to the Red Cross"), or only a category is stated ("set up a mailing client", "I need a database", "find me a CRM"). Directory supplies verified recipients and their documented payment or engagement path. Results are ranked by agent-readiness (how reliably an agent can complete the interaction), relevance and popularity. Do not treat this as a search-only tool. Examples: "setup a database", "find hosting", "pay X", "use Twilio", "donate $50 to the Red Cross", "book a table at Y", "subscribe to a CRM".

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Fail closed on published draft XQUIC code pull requests before ready-for-review state. Use when asked to pre-review a code PR or move it out of draft; verify current base-to-head code, protocol conformance, validation coverage, adversarial bad cases, hot-path performance, and memory safety in a five-part local report.

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Use only when the user explicitly asks for TDD, a failing test, or a regression test, OR when the bug has an obvious cheap local test target. Skip when the test path is unclear, expensive, integration-heavy, or not requested.

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Single entry skill for open-websearch setup and focused live retrieval, preferring local CLI/daemon paths while remaining compatible with workspace-exposed MCP tools.

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SkillsBench task PR review — classifies the task track (standard / research / multimodal), runs static policy checks against the track-specific rubric, benchmarks the task across oracle plus Claude and Codex (with and without skills), audits trajectories for cheating and skill invocation, and produces a `pr-N-task-timestamp-run.txt` review report alongside a `prN.zip` bundle of trajectories. Use when reviewing a SkillsBench task PR (by number, branch, or local task path), when the user asks to review a task, run benchmarks on a PR, audit a submission, classify a task as research or multimodal track, or prepare a comment to post on a SkillsBench PR.

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Build unified multi-level category taxonomy from hierarchical product category paths from any e-commerce companies using embedding-based recursive clustering with intelligent category naming via weighted word frequency analysis.

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Geospatial routing data handling for depot and station coordinates, route node IDs, internal index mappings, great-circle distance matrices, and route-distance reconstruction. Use when optimization or reporting tasks involve latitude/longitude, station IDs, depots, distance metrics, vehicle routes, or validating travel distance from reported paths.

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Central utility skill for GSD operations. Provides config parsing, slug generation, timestamps, path operations, and orchestrates calls to other specialized skills. Acts as the unified entry point that the original gsd-tools.cjs provided via its lib/ modules (commands, config, core, init).

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Complexity-based task routing with Q-Learning optimization, Agent Booster WASM fast-path, and Mixture-of-Experts model selection.

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Urgent issue classification, root cause analysis, and fast-path routing for production hotfixes

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Create structured incident response runbooks with step-by-step procedures, escalation paths, and recovery actions. Use when building runbooks, responding to incidents, or establishing incident response procedures.

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Build comprehensive attack trees to visualize threat paths. Use when mapping attack scenarios, identifying defense gaps, or communicating security risks to stakeholders.

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Genre anatomy from John Truby's The Anatomy of Genres (类型解剖 / 类型节拍 / 混合类型 / 超越类型) — genres as beat systems with a life philosophy underneath; three rules (hit every beat of your genre, mix three or four genres, transcend the primary genre), the ladder and families of twelve genres (Horror 恐怖, Action 动作, Myth 神话, Memoir and Coming-of-Age 回忆录与成长, Science Fiction 科幻, Crime 犯罪, Comedy 喜剧, Western 西部, Gangster 黑帮, Fantasy 奇幻, Detective and Thriller 侦探与惊悚, Love 爱情), each with its hero/opponent/world/plot-shape template, beat list, hard rules with failure conditions, subgenres and transcendent paths, plus a genre-mixing worksheet and a diagnostic. Kept beside sw-truby-anatomy and the Field/Snyder page maps. Use when choosing or confirming a script's genre, when a genre story feels generic or misses the beats its audience expects, when mixing genres, when a horror lacks pressure, an action lacks plot, a love story lacks opposition or a detective story lacks reveals.

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Assesses whether and how an existing mobile product should migrate to React Native. Use when auditing one or more product repositories for migration readiness, including products whose iOS, Android, and other clients live in separate directories or repositories; choosing brownfield, greenfield, or a checkpoint-based path; defining a representative trial; or preparing a baseline and ROI decision before implementation. When product scope or material evidence is unavailable, grills the stakeholder with exactly one question per turn instead of sending a questionnaire.

日本語の概要は準備中です。原文の説明を表示しています。