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概要と使いどころ
EXPERIMENTAL — mutation testing with muter to measure whether tests actually assert anything: mutants that survive reveal assertion-free coverage. Advisory report only, never a merge gate. Use on engine/logic targets when coverage numbers look good but bugs still slip through.
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We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs, and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories, and spatial locations; and generates in silico negative and positi
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We propose an Asymmetric Within-Sample Transformation (AWST) to regularize RNA-seq read counts and reduce the effect of noise on the classification of samples. AWST comprises two main steps: standardization and smoothing. These steps transform gene expression data to reduce the noise of the lowly expressed features, which suffer from background effects and low signal-to-noise ratio, and the influence of the highly expressed features, which may be the result of amplification bias and other experi
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KEGGGraph is an interface between KEGG pathway and graph object as well as a collection of tools to analyze, dissect and visualize these graphs. It parses the regularly updated KGML (KEGG XML) files into graph models maintaining all essenti
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cogeqc aims to facilitate systematic quality checks on standard comparative genomics analyses to help researchers detect issues and select the most suitable parameters for each data set. cogeqc can be used to asses: i. genome assembly and annotation quality with BUSCOs and comparisons of statistics with publicly available genomes on the NCBI; ii. orthogroup inference using a protein domain-based approach and; iii. synteny detection using synteny network properties. There are also data visualizat
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Expert guidance for designing, assessing, and optimizing Azure workloads using Azure Well Architected. Covers design review checklists, recommendations, design principles, tradeoffs, service guides, workload patterns, and assessment questions. Use when designing AI, HPC, SaaS, AVD/AVS workloads, choosing regions/AZs, or configuring core Azure services, and other Azure Well Architected related development tasks.
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Expert knowledge for Azure Stack Edge development including troubleshooting, best practices, decision making, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when deploying IoT Edge modules, GPU/Kubernetes apps, DeepStream workloads, Arc GitOps, or local ARM integrations, and other Azure Stack Edge related development tasks. Not for Azure IoT Edge (use azure-iot-edge), Azure Kubernetes Service (AKS) (use azure-kubernetes-service), Azure Kubernetes Service Edge Essentials (use azure-aks-edge-essentials), Azure Virtual Machines (use azure-virtual-machines).
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Enumerate every end-to-end feature as strict JSON entries with passes:false, editable-passes-only discipline, and priority order. The ledger fresh-context sessions read to know what's done, what's next, and what they're forbidden to touch.
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Build and execute brand marketing strategy for B2B companies — thought leadership, ABM brand layer, trust signals, LinkedIn presence, long sales cycle brand touchpoints, and enterprise credibility. Use when the user says "B2B marketing", "B2B brand", "business to business marketing", "selling to companies", "enterprise marketing", "we sell to businesses", "B2B brand strategy", "thought leadership strategy", "B2B content marketing", "account-based marketing brand", "B2B positioning", "how do we build trust with buyers", or is marketing a product or service sold to other businesses rather than consumers.
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Assess the health and consistency of an existing brand — identity, messaging, voice, positioning, and market perception. Use when the user says "brand audit", "brand review", "assess our brand", "is our brand consistent", "brand health check", "brand analysis", "something's off with our brand", "our brand feels outdated", "brand diagnosis", "review our brand", "brand gap analysis", or wants to understand where their brand is strong and where it needs work before investing in brand development.
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Diff two scaffolded harnesses (ADR-031). Reports manifest meta drift + host list + per-file fingerprint changes (added/removed/changed). Exits 0 IDENTICAL, 1 DRIFT, 2 missing manifest. Use --bundle for the ADR-031 schema-1 JSON envelope.
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Use when writing switch statements, refactoring if-else chains, creating data classes, choosing records vs classes, destructuring values, or modernizing pre-Dart-3 code.
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.NET / C# 二进制逆向。当目标是 .NET assembly（PE 头含 CLR、.exe/.dll 托管程序）、C# 编译产物（含 NativeAOT）、红队 Sharp* 工具（Rubeus / SharpHound / SharpHound 等）、.NET 混淆程序（ConfuserEx / SmartAssembly / Babel / Eazfuscator）、.NET loader / info-stealer / 套壳 malware 时使用。优先用 dnSpyEx + de4dot，需要 AI 直接操作时联动 dnSpy MCP。不用于纯 native 二进制（走 reverse-engineering / ida-reverse）。
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Use when the user asks for a visual or UI quality review of frontend code that already shipped, or passes a phase number. Produces {phase_num}-UI-REVIEW.md with a graded 1-4 assessment across six pillars.
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Agent Media OS, the single skill for every media need in a HyperFrames project. Resolve BGM, SFX, image, icon, brand logo, voice, color grade, or LUT into a frozen local file or paste-ready block + ledger record (one verb, `resolve`); generate via TTS / music / image models when the catalog misses; produce voiceover, transcription, captions, and background removal through one shared audio engine; operate on media (cut / reframe / transform); and reuse assets across projects. Also use for vague feedback that real footage looks dark, flat, boring, should feel retro/camcorder/print/ASCII, needs privacy, or needs a media reveal.
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Dung khi can brief mot chien dich cu the cho ca team thuc thi — muc tieu, thong diep, deliverable, timeline phan cong theo tuan, gate duyet va ma tran rui ro. Kich hoat khi user nhac 'brief chien dich', 'ke hoach campaign', 'len brief cho team', 'chien dich thang toi', 'phan cong campaign', 'timeline chien dich'. Khong dung cho — ke hoach marketing ca ky thi dung skill 00-ke-hoach-mkt; danh sach asset can thiet ke thi dung skill 41-campaign-asset-list; giao viec cho tung nguoi thi dung skill 64-team-brief.
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Dung khi can viet brief de XAY landing page moi hoac trang ban hang moi — cau truc section, copy tung khoi, yeu cau ky thuat, tracking va timeline giao dev. Kich hoat khi user nhac 'brief landing page', 'lam trang ban hang', 'can trang dich', 'thue dev lam landing', 'landing page can gi', 'viet noi dung cho trang'. Khong dung cho — trang DA CHAY ma khong ra don thi dung skill 68-cro-audit-trang; email HTML thi dung skill 49-html-email-template; danh sach asset cho ca campaign thi dung skill 41-campaign-asset-list.
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Dung khi can TAO RA anh hoac prompt anh bang AI — anh thuong hieu ca nhan, logo, key visual campaign, anh dang hang ngay, editorial, infographic, mockup web, quote graphic. Tu doc brand identity trong context roi dung prompt, gen anh hoac xuat prompt cho MidJourney, DALL-E, Imagen, Leonardo. Co che do nhan anh reference va tra ve master prompt copy-paste duoc. Kich hoat khi user nhac 'thiet ke anh', 'lam logo', 've banner', 'prompt MidJourney', 'tao key visual', 'lam anh giong anh nay', 'gen anh AI', 'doi mau thuong hieu tren anh'. Khong dung cho — viet brief giao designer lam thi dung skill 42-brief-hinh-anh; quy trinh asset ca campaign thi dung skill 41-campaign-asset-list; video avatar AI thi dung skill 24-ai-avatar-production; UI wireframe tuong tac thi dung web-prototype; animation thi dung motion-frames.
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Use when briefing or managing an EXTERNAL agency, freelancer, or production vendor — scope of work, deliverable specs, revision rounds, approval process, USD payment milestones, IP assignment and confidentiality terms, communication rules, and a post-project vendor scorecard. Trigger on 'brief an agency', 'hire a freelancer', 'scope of work', 'the agency is not delivering', 'onboard a new vendor', 'we keep paying for work we have to redo'. Also use when the user is about to sign a supplier with nothing written down. Not for — briefing an internal team member, see `64-team-brief-global`; the campaign brief itself, see `02-campaign-brief-global`; the asset list the vendor produces, see `41-campaign-asset-list-global`.
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Use when brand VISUAL rules have to be created or updated — brand personality, color system, typography, logo usage, imagery and visual tone, component rules, accessibility contrast, standard asset sizes, and file naming. It is the source document every design skill and the Brand Hub reads. Trigger on 'brand guideline', 'brand book', 'style guide', 'brand standards', 'our designs all look different', 'update the brand palette'. Also use when the user has a logo and nothing written down. Not for — how the brand SOUNDS in writing, see `35-brand-voice-global`; positioning and the message, see `58-positioning-global`; briefing one asset, see `42-image-brief-global`; scoring a design, see `47-design-review-global`.
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Decision guide for delegating to caveman-style subagents. Tells the main thread WHEN to spawn `cavecrew-investigator` (locate code), `cavecrew-builder` (1-2 file edit), or `cavecrew-reviewer` (diff review) instead of doing the work inline or using vanilla `Explore`. Subagent output is caveman-compressed so the tool-result injected back into main context is ~60% smaller — main context lasts longer across long sessions. Trigger: "delegate to subagent", "use cavecrew", "spawn investigator/builder/reviewer", "save context", "compressed agent output".
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Defines where UI components belong in Operately (TurboUI-first). Use when creating, changing, reviewing, or migrating UI components, adding features that need UI, or deciding whether to refactor legacy app UI in app/assets/js/components or app/assets/js/features. Covers pure TurboUI components, component reuse, the app bridge pattern, and legacy migration scenarios.
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Dart 3.x language feature standards: null safety, records, sealed classes, switch pattern matching, extensions, and async/await. Use when using !, ?., ??, late, sealed classes, record types, switch expressions, or async patterns — and before introducing any new Dart 3.x construct to confirm the modern idiomatic approach.
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Audit structural debt, logic leakage, and monolithic components across Web, Mobile, and Backend codebases. Use when reviewing architecture, assessing tech debt, detecting logic in wrong layers, or identifying God classes.
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