「chi」の検索結果

Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

日本語の概要は準備中です。原文の説明を表示しています。

Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.

日本語の概要は準備中です。原文の説明を表示しています。

Add MAUI DevFlow to a .NET MAUI project with agent package references, MauiProgram.cs registration, Blazor WebView support, GTK variants, Central Package Management guidance, and verification commands. USE FOR: first-time DevFlow setup, reviewing what files to edit, choosing DevFlow packages, or continuing after `maui devflow init` installs skills. DO NOT USE FOR: troubleshooting an already-integrated app that cannot connect, iterative app debugging, UI inspection, or generic MAUI build failures (use maui-devflow-debug). INVOKES: maui devflow CLI and dotnet CLI.

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Use when a carrier asks about trailer types — dry van, reefer, flatbed, step-deck, conestoga, tanker, dump, lowboy, intermodal chassis, auto-hauler. Covers length / weight rules, common specs, reefer unit options (Carrier vs Thermo King), liftgate options, kingpin setting, and trailer-to-tractor matching.

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Use this skill for training drivers on effective pre-trip inspection technique. Covers the comprehensive walk-around, time investment, and common areas drivers miss.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about driver ergonomics — back/neck/shoulder injury prevention, seat adjustment + lumbar support, entering and exiting cab safely, load handling techniques, vibration reduction, stretching protocols, and how ergonomics affects workers compensation costs in trucking. Reference OSHA + ATA ergonomics research.

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Discover failure modes in Coval runs, uploaded conversations or local conversation exports using scoped sampling and transcript, audio and trace evidence. Prepare human review without inventing ground truth or launching new runs.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user wants to design, redesign, shape, critique, audit, polish, clarify, distill, harden, optimize, adapt, animate, colorize, extract, or otherwise improve a frontend interface. Covers websites, landing pages, dashboards, product UI, app shells, components, forms, settings, onboarding, and empty states. Handles UX review, visual hierarchy, information architecture, cognitive load, accessibility, performance, responsive behavior, theming, anti-patterns, typography, fonts, spacing, layout, alignment, color, motion, micro-interactions, UX copy, error states, edge cases, i18n, and reusable design systems or tokens. Also use for bland designs that need to become bolder or more delightful, loud designs that should become quieter, live browser iteration on UI elements, or ambitious visual effects that should feel technically extraordinary. Not for backend-only or non-UI tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Strategic SEO planning for new or existing websites. Industry-specific templates, competitive analysis, content strategy, and implementation roadmap. Use when user says "SEO plan", "SEO strategy", "SEO planning", "content strategy", "keyword strategy", "content calendar", "site architecture", or "SEO roadmap".

日本語の概要は準備中です。原文の説明を表示しています。

Trial protocol for teaching AI Matrx an expert's knowledge until the platform breaks, fixing it. Use when asked to run an expertise trial, distil a person/creator/recent video into a Masterwork, or test the capture product. NOT for a known-missing feature (use build-sub-feature).

日本語の概要は準備中です。原文の説明を表示しています。

The cross-repo scheduling system (sch_* tables, matrx-scheduler). Use when touching features/scheduling/**, /schedules or /administration/scheduling, migrations/sch_*.sql, a scheduled agent, cron, trigger, lease, or claim, or debugging ghost tasks, missed fires, double-runs, or stuck claims.

日本語の概要は準備中です。原文の説明を表示しています。

Runbook for creating or majorly growing an @ai-matrx TypeScript npm package. Use when invoked as /new-package <name or capability>, or for a new @ai-matrx/* package, extracting code into one, or a major growth wave. NOT for a routine fix inside an existing package (THE SAME-SESSION LAW).

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the reviewer helper; the coach updates its Lessons after each round. Use only when acting as reviewer or coaching it. NOT for writing a verifier brief (use subagent-dispatch).

日本語の概要は準備中です。原文の説明を表示しています。

RichDocument action toolkit for markdown and interactive content outside live chat. Use when adding an action or content source, wiring a remote action surface, putting actions on a MarkdownStream/BasicMarkdownContent preview, or touching features/rich-document/**, <RichDocument>, <RichDocumentActionSurface>, registerAction, ContentSourceAdapter, or enableContextMenu. NOT for the live chat message bar (use overlay-system).

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the researcher helper; the coach updates its Lessons after each round. Use only when acting as researcher or coaching it. NOT for general research tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Delegating work down to subagents: briefs, report statuses, independent review. Use when writing an implementer or verifier brief, dispatching a subagent to build, fix, or verify work you own, or a subagent reports DONE, blocked, or concerns. NOT for campaign-scale doctrine (use campaign-pattern).

日本語の概要は準備中です。原文の説明を表示しています。

The Matrx user settings system (SettingsShell, useSetting, tab registry). Use when adding a preference or settings tab, binding a Redux slice to settings, wiring a settings deep link, or touching features/settings, components/official/settings, or components/user-preferences.

日本語の概要は準備中です。原文の説明を表示しています。

Custom-entry fix for pickers with no way to add a choice (Select, Popover list, DropdownMenu). Use when building or touching any choice control (tier, category, tag, status, owner), `pnpm check:picker-add` names a file, running Pattern Patrol P13, or the user says 'no way to add my own' or 'why can't I type a new one'.

日本語の概要は準備中です。原文の説明を表示しています。