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概要と使いどころ
Score, annotate, and analyze the functional impact of genetic variants using AlphaGenome Variant Impact (AVI) scores. Query variants in chr:pos:ref>alt format, annotate VCF/tabular callsets, perform saturation mutagenesis window scans (1-based closed chr:start-end), and extract GENCODE v46 GTF gene/exon/junction coordinates all via the AlphaGenome Atlas API.
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Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.
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Discover, find, compare, audit, repair, adapt, craft, run, debrief, save, and prepare repeatable AI-agent loops for publication. Use when a user asks to analyze code or coding threads for recurring work, find a published loop, interview them to turn a goal into a bounded loop, review a loop for weak checks or unsafe authority, execute a loop with an evidence receipt, learn from completed runs, save or reuse a project loop, or validate and submit a loop to Loop Library.
日本語の概要は準備中です。原文の説明を表示しています。
Run, monitor, resume, merge, and debug Ralph loops. Use this skill whenever the user asks to operate `ralph run` or `ralph loops`, inspect loop state, recover suspended loops, analyze diagnostics, or unblock merge queue issues.
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Conduct enterprise-grade research with multi-source synthesis, citation tracking, and verification. Use when user needs comprehensive analysis requiring 10+ sources, verified claims, or comparison of approaches. Triggers include "deep research", "comprehensive analysis", "research report", "compare X vs Y", or "analyze trends". Do NOT use for simple lookups, debugging, or questions answerable with 1-2 searches.
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Use this skill when users need to analyze competitors, monitor market movements, benchmark features/pricing, identify market gaps, or understand competitive positioning. Activates for "what are competitors doing," market analysis, or differentiation strategy.
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Deep-dive analysis of GitHub projects. Use when the user mentions a GitHub repo/project name and wants to understand it — triggered by phrases like "help me look at this project", "learn about XXX", "what is this project like", "analyze this repo", or any request to explore/evaluate a GitHub project. Covers architecture, community health, competitive landscape, and cross-platform knowledge sources.
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Debug Azure production issues on Azure using AppLens, Azure Monitor, resource health, and safe triage. WHEN: debug production issues, troubleshoot app service, app service high CPU, app service deployment failure, troubleshoot container apps, container app 503 or target port mismatch, troubleshoot functions, function telemetry missing or stopped after a config/connection-string change, troubleshoot AKS, VM RDP, Linux SSH, VM black screen, can't connect to VM, reset VM password, NSG or firewall blocking, kubectl cannot connect, kube-system/CoreDNS failures, pod pending, crashloop, node not ready, upgrade failures, analyze logs, KQL, insights, image pull failures, cold start issues, health probe failures, resource health, root cause of errors, troubleshoot event hubs, troubleshoot service bus, messaging SDK error, AMQP connection failure, message lock lost, lock renewal during long-running processing, service bus dead letter.
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Query and analyze data in Azure Data Explorer (Kusto/ADX) using KQL for log analytics, telemetry, and time series analysis. WHEN: KQL queries, Kusto database queries, Azure Data Explorer, ADX clusters, log analytics, time series data, IoT telemetry, anomaly detection.
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End-to-end orchestrator: from a business idea, app idea, or existing app to running Azure deployment with cost estimates and pre-deploy approval. Analyzes your app, auto-detects the right Azure services, scaffolds infrastructure code, and deploys — tailored to your app, not a template. Handles moving existing apps to Azure without rewriting or with minimal changes. WHEN: bring your app to Azure, plan my app, cost to run, is my code ready to deploy, deploy my app to the cloud, deploy all my services, what Azure services do I need, plan my Azure deployment, deploy my new app to Azure, one-click deploy, I have an app and want it on Azure, migrate my app to Azure, help me get started, build an app, no code yet, starter project. DO NOT USE FOR: use azd for deployment(use azure-deploy), optimizing existing costs (use cost-optimization), code readiness checks only (use azure-app-onboard-prereq).
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes git commit history and generates structured changelogs categorized by change type. Use when the user asks about recent changes, wants a changelog, or needs to understand what changed in the repository.
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Discovers available Azure OpenAI model capacity across regions and projects. Analyzes quota limits, compares availability, and recommends optimal deployment locations based on capacity requirements. USE FOR: find capacity, check quota, where can I deploy, capacity discovery, best region for capacity, multi-project capacity search, quota analysis, model availability, region comparison, check TPM availability. DO NOT USE FOR: actual deployment (hand off to preset or customize after discovery), quota increase requests (direct user to Azure Portal), listing existing deployments.
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Analyzes code repositories and generates hierarchical documentation structures with onboarding guides. Use when the user wants to create a wiki, generate documentation, map a codebase structure, or understand a project's architecture at a high level.
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Use this skill when a user wants to create, run, or analyze evaluation suites for Microsoft 365 Copilot declarative agents with the public @microsoft/m365-copilot-eval CLI. Trigger on intents such as "evaluate my agent", "test my agent", "run my evals", "create eval prompts", "add multi-turn tests", "tune evaluator thresholds", "why is my agent failing", or "set up eval environment variables".
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Analyze text and images for harmful content using Azure AI Content Safety (@azure-rest/ai-content-safety). Use when moderating user-generated content, detecting hate speech, violence, sexual content, or self-harm, or managing custom blocklists.
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Implement Conversational Language Understanding (CLU) using the azure-ai-language-conversations Python SDK. Use when working with ConversationAnalysisClient to analyze conversation intent and entities, building NLP features, or integrating language understanding into applications.
日本語の概要は準備中です。原文の説明を表示しています。
Azure AI Document Intelligence SDK for Java (com.azure:azure-ai-documentintelligence). Use for extracting text, tables, key-value pairs from documents, receipts, invoices, IDs, or building custom document models. Triggers: "document intelligence java", "form recognizer java", "extract text from PDF java", "OCR document java", "analyze invoice receipt java", "custom document model java", "document classification java".
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Analyze actual Azure spend, bill changes, and AKS or AI costs. WHEN: "Azure cost breakdown", "most expensive resources", "why did my bill increase", "cost spike", "unexpected charge", "Cosmos DB charges", "Foundry model costs", "AKS cluster cost", "namespace cost", "enable AKS cost analysis", "idle AKS capacity". DO NOT USE FOR: forecasts, pricing estimates, rightsizing, commitments, or budgets.
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Optimize existing Azure resources and analyze Reservations or Savings Plans. WHEN: "optimize Azure costs", "reduce cloud spending", "rightsize resources", "find idle resources", "orphaned disk", "deleted VM still charged", "public IP still charging", "reservation utilization", "Savings Plan coverage", "commitment recommendation", "why is pay-as-you-go still charged". DO NOT USE FOR: cost spikes, forecasts, pricing estimates, budgets, or governance.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze finance text sentiment using FinBERT or LLM. Use when the user needs to determine the sentiment (positive/negative/neutral) and score of financial text markets.
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Analyzes cfDNA methylation patterns for cancer detection using cfMeDIP-seq or bisulfite sequencing with MethylDackel. Identifies cancer-specific methylation signatures and performs tissue-of-origin deconvolution. Use when using methylation biomarkers for early cancer detection or minimal residual disease.
日本語の概要は準備中です。原文の説明を表示しています。
Tracks ctDNA dynamics over time for treatment response monitoring using serial liquid biopsy samples. Analyzes tumor fraction trends, mutation clearance kinetics, and defines molecular response criteria. Use when monitoring patients during therapy or detecting molecular relapse before clinical progression.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze PacBio Iso-Seq data for full-length isoform discovery and quantification. Use when characterizing transcript diversity or identifying novel splice variants.
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Analyze time-series RNA-seq data using limma voom with splines, maSigPro, and ImpulseDE2. Identify genes with dynamic expression patterns. Use when analyzing time-series or longitudinal expression data.
日本語の概要は準備中です。原文の説明を表示しています。