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Ensure a usable SageMaker execution role exists before deploying or training. Use this skill whenever about to create a SageMaker endpoint, model, training job, or any resource that requires an execution role. Use it especially when the user has not provided a role ARN explicitly, when scripts are about to call `iam:CreateRole`, or when an AccessDenied error mentions an IAM action. Never blindly call `iam:CreateRole` — always check for existing roles first. This skill prevents the most common SageMaker deployment failure: trying to create IAM resources from an SSO principal that has no IAM write permissions.

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Expert en Coolify avancé (self-hosting, Docker, déploiements, SSL, backups, gestion des ressources, multi-serveurs)

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Study a merged or shipped tdmcp implementation and extract reusable learnings: code improvements, runtime/UX lessons, test gaps, docs updates, roadmap items, and harness changes. Use when the user asks to learn from a completed feature/project/PR/build, analyze what can be improved from an implementation, or turn a real installation experience into actionable tdmcp improvements. This is a post-implementation learning harness; it does not replace tdmcp-pipeline for building or tdmcp-quality-audit for broad repo audits.

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Control motorized camera docks and enable intelligent subject tracking using DockKit. Use when discovering DockKit-compatible accessories, implementing camera subject tracking for faces or bodies, controlling dock motors for pan and tilt, configuring framing behavior, setting regions of interest, or building video apps with automatic camera tracking.

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Use when turning something that happened into something that makes the next run better - "write a retro", "record this paper cut", "this bug escaped verification", "make this an eval", "why do we keep hitting this", "did that change actually help", "scorecard", "what did we learn from that run", "lessons keep getting re-learned". Covers the six-step loop (capture, classify, convert, change, measure, retro), the repo artifact each step produces, and how escaped bugs become eval cases. Do NOT use to design or judge a single workflow experiment (see `workflow-experimentation`, which this loop feeds), to decide where to run work (see `dogfooding`), or to debug one failed execution in the moment.

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Expert patterns for HubSpot CRM integration including OAuth authentication, CRM objects, associations, batch operations, webhooks, and custom objects. Covers Node.js and Python SDKs. Use when: hubspot, hubspot api, hubspot crm, hubspot integration, contacts api.

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Azure Weights & Biases SDK for .NET. ML experiment tracking and model management via Azure Marketplace. Use for creating W&B instances, managing SSO, marketplace integration, and ML observability.

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You are an agent architect who has learned the hard lessons of autonomous AI. You've seen the gap between impressive demos and production disasters. You know that a 95% success rate per step means only 60% by step 10.

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bu skill covers implementing Okta as a centralized identity provider for cloud environments, configuring SSO integration with AWS, Azure, and GCP, Dağıt:ing phishing- resistant MFA with Okta FastPass, managing lifecycle automation for user provisioning and deprovisioning, and enforcing adaptive access policies based on device posture and risk signals.

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Generates publish-ready LinkedIn posts for B2B SaaS marketing leaders writing from an operator point of view: real decisions, real trade-offs, real constraints, and defensible lessons. Use when turning an internal observation, framework, campaign decision, miss, or shipped artifact into a public LinkedIn post. Best for demand generation, ABM, marketing ops, product marketing, and SaaS GTM leaders building credibility through practical operating insight. Not intended for generic brand posts, company announcements, sales outreach, or long-form content.

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Installs, configures, and tunes Snort 3 intrusion detection system to monitor network traffic for malicious activity using custom and community rulesets, preprocessors, and alert output plugins on authorized network segments.

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Map advanced persistent threat (APT) group tactics, techniques, and procedures (TTPs) to the MITRE ATT&CK framework using the ATT&CK Navigator and attackcti Python library. The analyst queries STIX/TAXII data for group-technique associations, generates Navigator layer files for visualization, and compares defensive coverage against adversary profiles. Activates for requests involving APT TTP mapping, ATT&CK Navigator layers, threat actor profiling, or MITRE technique coverage analysis.

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Analyzes UEFI bootkit persistence mechanisms including firmware implants in SPI flash, EFI System Partition (ESP) modifications, Secure Boot bypass techniques, and UEFI variable manipulation. Covers detection of known bootkit families (BlackLotus, LoJax, MosaicRegressor, MoonBounce, CosmicStrand), ESP partition forensic inspection, chipsec-based firmware integrity verification, and Secure Boot configuration auditing. Activates for requests involving UEFI malware analysis, firmware persistence investigation, boot chain integrity verification, or Secure Boot bypass detection.

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Statistical modeling — linear/logistic/ordinal/Poisson regression, ANOVA, Kruskal-Wallis, chi-square, Mann-Whitney, Cox survival, spline fits (R `ns()`), odds ratios, Cohen's d, F-statistic, p-value computation. Specializes in clinical-trial AE analysis (SDTM DM/AE), severity ordinal regression, and per-feature stat workflows.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Hamiltonian mechanics — symplectic integrators (leapfrog, Yoshida), Hamilton's equations, Poisson brackets, canonical transformations, action-angle variables, and KAM theory analysis. Use for energy-conserving long-time integration of conservative systems.

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Python library for working with geospatial vector data including shapefiles, GeoJSON, and GeoPackage files. Use when working with geographic data for spatial analysis, geometric operations, coordinate transformations, spatial joins, overlay operations, choropleth mapping, or any task involving reading/writing/analyzing vector geographic data. Supports PostGIS databases, interactive maps, and integration with matplotlib/folium/cartopy. Use for tasks like buffer analysis, spatial joins between datasets, dissolving boundaries, clipping data, calculating areas/distances, reprojecting coordinate systems, creating maps, or converting between spatial file formats.

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Selects biomarker features from high-dimensional omics data using Boruta all-relevant selection, mRMR, LASSO/elastic-net, and stability selection, while controlling the leakage, irreproducibility, and correlated-feature traps that make most published signatures fail to replicate. Use when identifying candidate biomarkers, deciding between an all-relevant and a minimal-optimal selector, or judging whether a selected gene set is reproducible. For unbiased performance estimation of the resulting model see machine-learning/model-validation; for interpreting a trained model see machine-learning/prediction-explanation.

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Orchestrates an end-to-end MeRIP-seq / m6A-seq analysis from raw FASTQ to differential m6A peak calls and metagene plots, chaining fastp adapter trimming, STAR splice-aware alignment (NO deduplication for non-UMI MeRIP), deepTools replicate-concordance + IP-enrichment QC, PreSeq saturation curves, exomePeak2 (transcript-aware Poisson GLM) peak calling, optional MACS3 broad-peak cross-check, DRACH motif confirmation as a sanity check (NOT a per-peak filter), exomePeak2 differential calling via the four-BAM-vector interface (bam_ip + bam_input control; bam_treated_ip + bam_treated_input treatment), ChIPseeker annotation, and the canonical Guitar metagene with stop-codon enrichment as the biological QC anchor. Use when running a complete MeRIP analysis from raw reads, when chaining the constituent epitranscriptomics skills (merip-preprocessing -> m6a-peak-calling -> m6a-differential -> modification-visualization), or when wrapping the pipeline in Snakemake / Nextflow.

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End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, leakage-safe cross-validation, calibration, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.

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Drug and chemical toxicity assessment via adverse outcome pathways (AOPs), real-world FAERS adverse event signals, FDA labels, and toxicogenomic associations. Triangulates molecular initiating event to cellular outcome to organ-level toxicity to clinical adverse event. Use for hepatotoxicity/cardiotoxicity/nephrotoxicity prediction and toxicology reports.

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Drug safety and adverse event analysis — FAERS spontaneous-report mining, FDA black-box warnings, signal detection (PRR, ROR, IC), risk factors by demographic/comorbidity, and label change tracking. Use for post-market safety surveillance, AE signal investigation, drug-AE association strength scoring, and pharmacovigilance reports.

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Pharmacogenomics (PGx) research — drug-gene interactions (CPIC, PharmGKB), CPIC dosing guidelines, variant-drug-response associations, ethnic-allele-frequency considerations, and metabolizer-status scoring. Use for PGx-informed dosing recommendations, CYP/HLA pharmacogenomic allele interpretation, and clinically-actionable PGx report generation.

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