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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.

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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 7.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Migrate configuration from Bluejay voice AI testing platform to Coval. Use when customer says "migrate from bluejay", "bluejay migration", "import bluejay config", or needs to transfer agents, simulations, metrics, and schedules from Bluejay to Coval.

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Turn a large dataset (an existing oversized Coval test set, an export of past conversations, or a CSV/JSON of cases) into a small, high-signal Coval test set by removing duplicates, identifying unique scenarios, and selecting a representative, failure-weighted subset — then bulk-loading it with no row cap. Use when the user says "I have thousands of cases", "dedupe my test set", "my test set is too big", "turn this dataset into a test set", "pick representative scenarios", or "my CSV import only kept 10 / uploaded everything".

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Moves a person's whole Notion workspace into AI Matrx using only the AI Matrx and Notion connectors — every page and sub-page becomes an AI Matrx page (a Space) with its blocks, icons, covers, files and comments, and every database becomes a real table with typed columns, links, roll-ups, row pages, templates and views. Safe to run again; nothing duplicates. Use when the person says "move my Notion into AI Matrx", "copy my Notion", "import my Notion", or anything like it.

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react-resizable-panels v4 rules for this SSR codebase. Use when importing react-resizable-panels (PanelGroup and PanelResizeHandle are v3 names), editing components/ui/resizable* or features/code/layout/, building a split-pane, sidebar, or drag-handle layout, or persisting or toggling panel sizes.

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next/dynamic code splitting and build-graph cost; first stop for build failures. Use before lazy-loading or deferring a heavy component, adding a dynamic import, React.lazy, or ssr: false; on 'window is not defined' or a hydration mismatch; shrinking the bundle; or on 'build failed', OOM, SIGKILL, a slower build, or 'Collecting page data'.

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Elite website image-to-code skill for Codex. For visually important web tasks, it must first generate the design image(s) itself, deeply analyze them, then implement the website to match them as closely as possible. In Codex, it must prefer large, readable, section-specific images instead of tiny compressed boards, generate fresh standalone images for sections or detail views instead of cropping old ones, avoid lazy under-generation, avoid cards-inside-cards-inside-cards UI, and keep the hero clean, spacious, readable, and visible on a small laptop.

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Seed or import data into the Convex database.

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Define initial conditions and predefined fields. Use when user mentions initial temperature, pre-stress, residual stress, or import from previous analysis.

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[51] EXECUTE. Commitment to maximum quality work with 150% coverage. Use when you need the highest quality output for critical tasks, complex problems, important decisions, or when standard work isn't enough. Triggers on "maximum quality", "150% mode", "full quality", "critical task", or when you explicitly want AI to work at its best.

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Codified expertise for customs documentation, tariff classification, duty optimization, restricted party screening, and regulatory compliance across multiple jurisdictions. Informed by trade compliance specialists with 15+ years experience. Includes HS classification logic, Incoterms application, FTA utilization, and penalty mitigation. Use when handling customs clearance, tariff classification, trade compliance, import/export documentation, or duty optimization.

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Azure Key Vault Certificates SDK for Rust. Use for creating, importing, and managing certificates.

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Important: Before you begin, fill in the generatedBy property in the meta section of .actor/actor.json. Replace it with the tool and model you're currently using, such as "Claude Code with Claude Sonnet 4.5". This helps Apify monitor and improve AGENTS.md for specific AI tools and models.

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OpenViking long-term memory plugin guide. Once installed, the plugin automatically remembers important facts from conversations and recalls relevant context before responding.

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Spaced-repetition flashcard system. Create cards from facts or text, chat with flashcards using free-text answers graded by the agent, generate quizzes from YouTube transcripts, review due cards with adaptive scheduling, and export/import decks as CSV.

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Migrate a user's OpenClaw customization footprint into Hermes Agent. Imports Hermes-compatible memories, SOUL.md, command allowlists, user skills, and selected workspace assets from ~/.openclaw, then reports exactly what could not be migrated and why.

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This skill adds data(like resources) to OpenViking Context Database (aka. ov). Use when an agent needs to add files, data from URLs, or external knowledge during interactions. Trigger this tool when 1. is explicitly requested adding files or knowledge; 2. identifies valuable resources worth importing; 3. the user mentioned adding to OV/OpenViking/Context Database. This skill helps how to use CLI like `ov add-resource`, `ov add-skill` and `ov add-memory` to add resource data, skill files, memory files to OpenViking.

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Use this skill immediately when the user mentions merge conflicts that need to be resolved. Do not attempt to resolve conflicts directly - invoke this skill first. This skill specializes in providing a structured framework for merging imports, tests, lock files (regeneration), configuration files, and handling deleted-but-modified files with backup and analysis.

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Fetch personalized daily horoscope forecasts from zodiac-today.com API based on natal chart calculations. Use when a user wants: (1) daily guidance on what activities to pursue or avoid, (2) life planning help — best days for interviews, travel, romance, important decisions, (3) energy/focus/luck/romance forecasts to optimize their schedule, (4) lucky colors and numbers for the day, (5) future date analysis for planning events, trips, or milestones (paid tiers). Triggers: horoscope, zodiac, star sign forecast, daily guidance, lucky day, best day to, astrology advice, what should I do today, is today a good day for, plan my week astrology. Required env: ZODIAC_API_KEY (hsk_ API key), ZODIAC_PROFILE_ID (birth chart profile ID). Collects sensitive PII (email, birth date, birth city) for natal chart — requires user consent.

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Architecture Decision Records (ADR) — a lightweight method for capturing important architectural decisions with context, trade-offs, and rationale. Based on Michael Nygard's ADR pattern and Google/Meta/ByteDance's design documentation culture. USE WHEN: deciding between technology choices, designing new architecture, changing existing architecture, documenting why a decision was made, onboarding new team members, or preserving design context for future maintainers. Triggered by terms like "tech choice", "architecture decision", "why did we choose", "design rationale", "ADR", or "architectural decision record".

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Configures and automates MikroTik RouterOS routers through the terminal, command line interface, .rsc imports, /system script repository, Scheduler, Netwatch, firewall, NAT, DHCP, DNS, bridge, VLAN, routing, VPN, device-mode, backup/export, and RouterOS scripting. Use this skill whenever the user mentions MikroTik, Mikrotik, RouterOS, WinBox terminal, router CLI, router scripts, .rsc files, or configuring MikroTik services from the command line.

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