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Validate digital outputs for compliance with accessibility standards (e.g., WCAG, Section 508). Use when reviewing reports, dashboards, documents, or interfaces from pilot projects to identify and remediate accessibility barriers.

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Refactor a whole documentation page in this repository without losing source-verified behavior facts. Use for page rewrites, splits, reorganizations, or substantial shortening of README sections, docs pages, or instruction files. Do not use for ordinary documentation authoring, targeted corrections, or documentation review; use technical-documentation instead.

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Triage a GitHub issue that already has the cc-issue-created label and is assumed ready to start. Inspect the comment history first to decide whether human confirmation is needed (cc-need-human-check, highest priority — reserved for issue-level deadlock, or for confirmation items answer-issue-questions already investigated and explicitly marked unanswerable); otherwise close the issue as not needed, delegate unanswered confirmation items in the last comment or the description to answer-issue-questions (cc-answer-issue-questions), refresh a description stale relative to settled comment-history content (cc-update-issue), or move to execution (cc-exec-issue). Any UI-changing issue is routed to the design-first flow (cc-create-ui-design) before execution; the exceptions are an issue whose description already names the .pen design to implement against, and a minor UI change that introduces no new visual decision (no new screen/section, no layout change, no new reusable component, no visual expression outside existing design tokens/components). Design files are never edited in the implementation PR. Dependency checks are out of scope.

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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM; Liu 2022 *NAR Genom Bioinform* 4:lqac046), MeTPeak (HMM over sliding windows; Cui 2016 *Bioinformatics* 32:i378), MACS3 / MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment confirmation via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output formats, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union; cross-caller IDR-equivalent), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody-based methods cannot resolve, and orthogonal-validation routes (miCLIP / GLORI / m6A-SAC-seq / m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set as a whole, reconciling differing peak sets across tools, validating MeRIP peaks against orthogonal single-base methods, interpreting peaks at the 5' end where m6Am contamination is possible, or recommending a multi-tool consensus strategy.

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Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Automate Asana tasks via Rube MCP (Composio): tasks, projects, sections, teams, workspaces. Always search tools first for current schemas.

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Important: Before you begin, fill in the generatedBy property in the meta section of .actor/actor.json. Replace it with the tool and model you're currently using, such as "Claude Code with Claude Sonnet 4.5". This helps Apify monitor and improve AGENTS.md for specific AI tools and models.

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Export/publish the live portfolio tracker as a static, stripped snapshot into the "Portfolio Snapshot" folder — an empty Trades section (first), the holdings table, and the 1-month-return bar chart baked to static SVG (scatter chart opt-in), with a Publish_Snapshot property. Strips all instruction/engine/log elements (refresh dataviewjs, tip callouts, Upcoming Earnings, Column Legend, Notes, Log). Use when the user says "snapshot the portfolio", "publish the portfolio", "export Live Portfolio", or "portfolio snapshot".

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A modern, graphic, editorial-poster aesthetic — warm and confident — built on alternating cream and burnt orange sections, an amber brand color.

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A playful, joyful, two-color risograph print aesthetic built on a single warm off-white paper surface running through every section

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Magazine-grade, collage-driven editorial system: warm paper canvas, surreal plaster-and-architecture imagery, oversized display type, hairline rules, and Roman-numeral section markers.

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Generate a single-file product landing page with a layered ASCII cosmos hero (rotating ASCII planet, drifting irregular asteroids, comet trails, nebula gas clouds — each in its own harmonious color) plus full marketing sections (about / features grid / showcase / spec / pricing / CTA / footer). Takes a natural-language description of one product (any kind — a note app, a coffee subscription, a CLI tool, an indie hardware, a hosting service…) and outputs ONE working .html file with deep-space dark or warm-letterpress theme. Runs in BOTH Claude Code (writes to ~/Desktop) and GLM / online chat (outputs HTML inline). Trigger phrases: "做个宇宙风产品落地页", "生成 ASCII 产品官网", "ascii-cosmos-gen ...", "做个独立软件 / 独立硬件落地页", or when user drags this skill folder into chat asking for an atmospheric product landing page.

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Canonical UI/UX best practices ruleset with 14 sections and 70+ rules prioritized P0–P3. Use when implementing, reviewing, or auditing UI components. P0 rules are mandatory — violations are bugs. All rules reference tokens from ui-theme-reference.

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Write and refine high-quality user stories — INVEST criteria, "As a X, I want Y, so that Z" format, Gherkin acceptance criteria when applicable, definition of ready, anti-patterns, and a review checklist. Use when creating or reviewing user stories, PRD section 6, backlog items, or acceptance criteria. Do NOT use for technical specs, architecture decisions, or task decomposition.

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Autonomous themed tech-debt cleanup. Reads docs/architecture/debt-ledger.yml, rotates to the least-recently-served debt theme, works it for a time budget (default 2h) or until drained, opens one PR, and asks judgment questions inline at the end. Use for daily debt burndown without Peter pointing at a target: grandfathered analyzer rules, architecture-test baselines, obsolete-field reads, cross-section stitching.

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Two-phase memory hygiene. Phase 1: scan external Claude Code memory (~/.claude/projects/<slug>/memory/) for durable rules to migrate into the repo and entries already duplicated by repo atoms. Phase 2: audit in-repo memory/, CLAUDE.md, docs/architecture/, and docs/sections/ for dead links, duplication, drift, and bloat.

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Autonomous Reforge-guided refactor workflow for the Humans repository. Use when the user wants Codex to target a section such as Shifts, Users, Teams, Tickets, Camps, or Store, create a dedicated worktree/branch from origin/main, run iterative architecture-focused improvements, score each stage with Reforge, gate commits through a score-blind read-only architecture review, append score and verdict details to commit messages after review acceptance, push progress, and open a PR when the loop reaches stasis.

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Stryker-driven test cull: delete slop, consolidate redundants, fill mutation-coverage gaps. Score up, test count and lines down. Use when the user says 'trim tests', '/trim-tests', or wants to clean up LLM-generated test bloat. No args picks the worst-scored file; argument scopes to a section, service, or file.

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When the user wants to write, rewrite, or improve marketing copy for any page — including homepage, landing pages, pricing pages, feature pages, about pages, or product pages. Also use when the user says "write copy for," "improve this copy," "rewrite this page," "marketing copy," "headline help," "CTA copy," "value proposition," "tagline," "subheadline," "hero section copy," "above the fold," "this copy is weak," "make this more compelling," or "help me describe my product." Use this whenever someone is working on website text that needs to persuade or convert. For email copy, see email-sequence. For popup copy, see popup-cro. For editing existing copy, see copy-editing.

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Generate structured HTML from authoring analysis for AEM Edge Delivery Services. Creates section structure, applies block tables, handles metadata, and manages images folder.

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Static-to-EDS conversion that preserves the original design while making content authorable in Document Authoring. Two modes — page-level (overlay template with slot markers) and block-level (each section becomes an independent EDS block). Use when converting an AI-generated static HTML page (Stardust, Mobirise, Relume, Lovable, v0, Figma-derived hand-coded, etc.) into an Edge Delivery Services page. Triggers on "convert this page to EDS", "static-to-EDS overlay", "convert to EDS blocks", "next experimentation", "next run", "start run", or when a user provides a source URL and asks to make it editable in DA while keeping the original design intact. Do NOT use for canonical EDS block-rewrite migrations — that's the page-import skill.

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Create or edit the Universal Editor component configuration (component-definition.json, component-models.json, component-filters.json) for AEM Edge Delivery Services blocks. Use this skill whenever the user mentions component models, component definitions, component filters, block configuration for the Universal Editor, UE block setup, adding a new block to UE, configuring block properties, block authoring fields, or any task involving the three JSON config files that control how blocks appear in the Universal Editor. Also trigger when the user wants to create a new EDS/Franklin block with UE support, modify block fields, add a block to the section filter, or asks about how blocks connect to the Universal Editor.

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Analyze content sequences and determine authoring approach (default content vs blocks). Validates block selection and section styling for import/migration to AEM Edge Delivery Services.

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