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概要と使いどころ
Use this skill when a user wants to create, run, or analyze evaluation suites for Microsoft 365 Copilot declarative agents with the public @microsoft/m365-copilot-eval CLI. Trigger on intents such as "evaluate my agent", "test my agent", "run my evals", "create eval prompts", "add multi-turn tests", "tune evaluator thresholds", "why is my agent failing", or "set up eval environment variables".
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Create Pydantic models following the multi-model pattern with Base, Create, Update, Response, and InDB variants. Use when defining API request/response schemas, database models, or data validation in Python applications using Pydantic v2.
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Align long reads using minimap2 for Oxford Nanopore and PacBio data. Supports various presets for different read types and applications. Use when aligning ONT or PacBio reads to a reference genome for variant calling, SV detection, or coverage analysis.
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Analyze PacBio Iso-Seq data for full-length isoform discovery and quantification. Use when characterizing transcript diversity or identifying novel splice variants.
日本語の概要は準備中です。原文の説明を表示しています。
Quality control and normalization for metabolomics data. Covers QC-based correction, batch effect removal, and data transformation methods. Use when correcting technical variation in metabolomics data before statistical analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Amplicon sequence variant (ASV) inference from 16S rRNA or ITS amplicon sequencing using DADA2. Covers quality filtering, error learning, denoising, and chimera removal. Use when processing demultiplexed amplicon FASTQ files to generate an ASV table for downstream analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Track bacterial strains using MASH, sourmash, fastANI, and inStrain. Compare genomes, detect contamination, and monitor strain-level variation. Use when needing sub-species resolution for outbreak tracking, transmission analysis, or within-host strain dynamics.
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Remove batch effects from RNA-seq data using ComBat, ComBat-Seq, limma removeBatchEffect, and SVA for unknown batch variables. Use when correcting batch effects in expression data.
日本語の概要は準備中です。原文の説明を表示しています。
Batch effect correction for CRISPR screens. Covers normalization across batches, technical replicate handling, and batch-aware analysis. Use when combining screens from multiple batches or correcting systematic technical variation.
日本語の概要は準備中です。原文の説明を表示しています。
Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.
日本語の概要は準備中です。原文の説明を表示しています。
Detect copy number variants from targeted/exome sequencing using CNVkit. Supports tumor-normal pairs, tumor-only, and germline CNV calling. Use when detecting CNVs from WES or targeted panel sequencing data.
日本語の概要は準備中です。原文の説明を表示しています。
JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens) for modeling sgRNA efficacy and gene essentiality. Use when analyzing multiple CRISPR screens simultaneously or when accounting for variable sgRNA efficiency across experiments.
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Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.
日本語の概要は準備中です。原文の説明を表示しています。
Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.
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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for causal inference.
日本語の概要は準備中です。原文の説明を表示しています。
Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.
日本語の概要は準備中です。原文の説明を表示しています。
Apply Steve McConnell-inspired construction rules when implementing routines, variables, classes, control flow, defensive code, or tests.
日本語の概要は準備中です。原文の説明を表示しています。
Calculate contract-based futures position sizes from a direction, entry, and stop-loss, using verified per-symbol contract specs (multiplier, tick size, tick value). Use when the user asks how many futures contracts to trade, wants to size a futures position (ES, NQ, ZB, GC, CL, 6E/E6, VX, BT, ...), or is handing off a contrarian-setup-gate READY_FOR_PLAN direction/invalidation_level for sizing. Pure, offline calculation -- no API keys, no network.
日本語の概要は準備中です。原文の説明を表示しています。
Convert abstract edge concepts into strategy draft variants and optional exportable ticket YAMLs for edge-candidate-agent export/validation.
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user asks to "design an employee advocacy program", "set up founder-led sharing", or "build a share kit for the team"; produces an advocacy program blueprint in two modes — participation-driven opt-in (default) or top-down assigned with its coercion and authenticity risks flagged — with a voluntary opt-in roster spec submitted as channel-registry proposal events, share kits with mandatory per-person variation, staggered human posting windows plus anti-pod guardrails (no coordinated identical reshares, no engagement rings), per-person material-connection disclosure lines per FTC and 《互联网广告管理办法》, and a Slack/Teams distribution spec. Not for paid creator campaigns — use campaign-planner. 员工倡导/创始人IP分享/内部分享计划/披露合规
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user asks to "turn this idea into posts for every platform", "write the X thread / LinkedIn post / 小红书 note", or "spec the carousel slides"; turns one idea into N platform-native ready-to-paste packages — post/thread, caption, Threads text, 小红书 note, link post with first-comment placement — each adapted per the dated platform norm card (never verbatim cross-posting), every product claim held to approved claims-ledger wording or flagged [needs source], every variant tagged {formula | hook family | CTA type | signal optimized}, plus a carousel slide-spec mode (intro/content/outro slide roles, per-element char budgets, 小红书 3:4 / IG 4:5 / LinkedIn document PDF artboards, text-safe-zone + alt-text checklist). Not for creator deliverable briefs — use brief-generator; not for repurposing existing assets with paid boost — use content-amplifier. 社媒文案/一稿多发改写/小红书笔记/轮播图脚本
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user asks to "plan the participation ramp before we promote", "how much account history or karma do we need in this community", or "design entry incentives and member lifecycle for our own Discord"; produces the per-community pre-promotion warming plan — account-history/tenure expectations (Estimated, named sources), a give-before-ask ledger spec, a per-community etiquette + rule digest with last-verified dates, and the warming → active graduation criteria that channel-registry requires as state-transition evidence — plus the owned-community variant (entry paths + member lifecycle for your own Discord/Slack/forum/企业微信私域). Not for launch-day submissions or T-0 threads — use community-launch-runner. 社区预热/先给后取/账号养成/毕业标准
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Use when the user asks to "track our share of voice", "what share of the conversation do we own vs competitors", or "trend our SOV this quarter"; computes SOV% = brand mentions ÷ (brand + competitor panel mentions) per platform per period on a LOCKED competitor panel — a panel switch invalidates the trend (restart the series and log the break; the ECHO O3 rule) — plus a sentiment-weighted SOV variant (sentiment labeled Estimated unless human-coded) and a Wikipedia-pageviews attention-share alternative; built from keyless listening connectors, gdelt.py news echo, and user exports — public counts only, closed platforms are never scraped. Not for backlink or offsite SEO signals — use offsite-signal-analyzer. 声量份额/竞品声量对比/提及份额/注意力份额
日本語の概要は準備中です。原文の説明を表示しています。
Use when the user asks to "monitor brand mentions", "set up social listening", "did anything spike about us this week", or "watch these accounts for buying triggers"; runs always-on keyless listening — a versioned listening-query architecture (brand variants incl. misspellings and 中文 names, exclusion terms, per-source syntax for HN Algolia / Bluesky / GDELT / Tavily), a mention sweep with six-class triage (crisis / bug / lead / praise / question / spam) each routed with an SLA, a 7-day rolling baseline with spike flags (the crisis trigger input), a B2B trigger watchlist (funding / hiring / launch signals), and an explicit coverage disclosure where X/IG/TikTok/LinkedIn/小红书 numbers are proxy-labeled, never Measured. Not for launch-window telemetry (T-0→T+30 rank and review polling) — use launch-monitor. 舆情监听/品牌提及监测/基线突刺/触发信号
日本語の概要は準備中です。原文の説明を表示しています。