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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Refactor Spring Boot and Java code to improve maintainability, readability, and adherence to enterprise best practices. This skill transforms messy Spring Boot applications into clean, well-structured solutions following SOLID principles and Spring Boot 3.x conventions. It addresses fat controllers, improper transaction boundaries, field injection anti-patterns, and scattered configuration. Leverages Java 21+ features including record patterns, pattern matching for switch, virtual threads, and sequenced collections.

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Run a structured Red-Green-Refactor TDD cycle — write a failing test first, implement the minimum code to pass it, then refactor with the suite green.

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Run the refactor workflow — mandatory architectural justification, test verification, risk-based implementation, and scope enforcement.

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Testing patterns for multi-tenant Django POS projects using pytest-django, RequestFactory, and mocks. No factories, no complex conftest. Trigger: When writing or reviewing tests in any apps/ directory.

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t-wada式TDD（テスト駆動開発）でRED→GREEN→REFACTORサイクルを使ってテストファーストで開発を進めるスキル。 ユーザーが「TDDで実装して」「テストファーストで」「t-wada式で」「REDから始めて」「失敗するテストを先に」と言った場合は必ずこのスキルを使うこと。 FizzBuzz、スタック、認証、バリデーションなど、あらゆる実装タスクにTDDアプローチを適用できる。 ユーザーが実装を始めようとしているときは積極的にTDDを提案すること。

Guide for building and refactoring a FastAPI + Prefect + PostgreSQL/pgvector analytics pipeline that extracts insights from chat data using LLM classification, embeddings, UMAP/HDBSCAN clustering, and narrative generation. Use this skill whenever working on this project's codebase — including adding features, refactoring, debugging, creating new endpoints, modifying pipeline stages, or reviewing architecture decisions. Also trigger when the user asks about project structure, stack decisions, async migration, or best practices for this specific system.

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Forces the laziest solution that actually works, simplest, shortest, most minimal. Channels a senior dev who has been paged at 3am for a factory class that wrapped one function: question whether the task needs to exist at all, reach for the standard library before custom code, native platform features before dependencies, one line before fifty. Supports intensity levels: lite, full, ultra. The default is full. Use on ANY coding task: writing, adding, refactoring, fixing, reviewing, or designing code, and choosing libraries or dependencies. Also use whenever the user says "ponytail", "be lazy", "lazy mode", "simplest solution", "minimal solution", "yagni", "do less", or "shortest path", or complains about over-engineering, bloat, boilerplate, or unnecessary dependencies. Do NOT use for non-coding requests such as general knowledge, prose, translation, summaries, recipes.

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Claude Code の過去のセッション記録（~/.claude の履歴・セッションログ・memory）から、他のメンバーと共有できる運用 Tips を抽出し、公式ドキュメントや論文などの一次情報で裏付けを取って、Markdown・Artifact・Notion に公開する。「過去の会話から Tips をまとめて」「Claude Code の使い方をチームに共有したい」「今月の学びを Tips にして」などの依頼で使う。セッション 1 本の効率採点ではない（それは evaluate-session の領域）。週次のナレッジカード提出は knowledge-cards で行い、このスキルはカードや記録から Tips 文書を作る下流工程にあたる。

OpenViking long-term memory plugin guide. Once installed, the plugin automatically remembers important facts from conversations and recalls relevant context before responding.

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Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.

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AI-assisted pair programming with multiple modes (driver/navigator/switch), real-time verification, quality monitoring, and comprehensive testing. Supports TDD, debugging, refactoring, and learning sessions. Features automatic role switching, continuous code review, security scanning, and performance optimization with truth-score verification.

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Supermemory is a state-of-the-art memory and context infrastructure for AI agents. Use this skill when building applications that need persistent memory, user personalization, long-term context retention, or semantic search across knowledge bases. It provides Memory API for learned user context, User Profiles for static/dynamic facts, and RAG for semantic search. Perfect for chatbots, assistants, and knowledge-intensive applications.

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Route design-related HTML artifact tasks to the right artifact skill, reference, design system generation, or export skill.

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Use when an existing skill must be refactored to cut context and ambiguity without losing behavior, safety or fallbacks — 'refatorar a skill', 'reduzir esta SKILL.md', 'revisar skill com métricas' — with before/after metrics, preserved invariants and three review rounds.

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Improve code structure, readability, and maintainability without changing external behavior through systematic refactoring techniques like extracting functions, removing duplication, simplifying conditionals, and applying design patterns. Use when reducing technical debt, extracting functions or classes, removing code duplication, simplifying complex conditionals, renaming for clarity, applying design patterns, improving code organization, reducing coupling, increasing cohesion, or maintaining test coverage during structural improvements.

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Create interactive, self-contained artifacts like mini-apps, visualizations, calculators, and tools that can be embedded or used standalone. Use when building interactive calculators, creating data visualizations, making mini web apps, building embeddable widgets, creating interactive demos, making tools for specific tasks, or generating standalone HTML/JS applications.

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Autonomous Reforge-guided refactor workflow for the Humans repository. Use when the user wants Codex to target a section such as Shifts, Users, Teams, Tickets, Camps, or Store, create a dedicated worktree/branch from origin/main, run iterative architecture-focused improvements, score each stage with Reforge, gate commits through a score-blind read-only architecture review, append score and verdict details to commit messages after review acceptance, push progress, and open a PR when the loop reaches stasis.

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Turn any markdown file into a publication-quality PDF. Proper 1in margins, intelligent page breaks, page numbers, cover pages, running headers, curly quotes and em dashes, clickable TOC, diagonal DRAFT watermark. Not a draft artifact — a finished artifact. Use when asked to "make a PDF", "export to PDF", "turn this markdown into a PDF", or "generate a document". (gstack) Voice triggers (speech-to-text aliases): "make this a pdf", "make it a pdf", "export to pdf", "turn this into a pdf", "turn this markdown into a pdf", "generate a pdf", "make a pdf from", "pdf this markdown".

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Refactor and review SwiftUI view files for consistent structure, dependency injection, and Observation usage. Use when asked to clean up a SwiftUI view’s layout/ordering, handle view models safely (non-optional when possible), or standardize how dependencies and @Observable state are initialized and passed.

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Refactor code to improve quality while maintaining functionality. Use when you need to improve code structure, eliminate duplication, optimize performance, or enhance maintainability without changing behavior.

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Test-driven development with red-green-refactor loop. Use when user wants to build features or fix bugs using TDD, mentions "red-green-refactor", wants integration tests, or asks for test-first development.

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