「signal」の検索結果

Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

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Analyze TF motif accessibility variability across samples or single cells using chromVAR. Use when identifying TF motifs whose accessibility correlates with conditions, computing per-sample motif z-scores after matched background correction, comparing to ArchR / Signac equivalents, or distinguishing motif-accessibility signal from per-site footprinting.

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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

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EXPERIMENTAL. Join or leave an org-team coordination channel as a session peer. `/companion on <channel_id> [peer_id]` registers this Claude Code session as a `pclass:"session"` peer and works the claim → execute → signal loop, escalating un-decidable forks to the lead (never deciding). `/companion off` deregisters. `/companion status` reports the current peer. Part of org mode (Article X), which is opt-in via `velocity.org_mode.enabled` and OFF by default. Use when a human launches a second session to act as a peer alongside a lead.

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An infographic skill for AI agents — works inside Claude Code, Codex, Hermes, OpenClaw, Cursor, and any agent host that loads skills. Create professional infographics as self-contained HTML files with PNG exports. Use when the user asks to create, design, generate, build, or make an infographic, data visualization, visual explainer, chart poster, cheatsheet, or pocket guide. Trigger phrases include "make this visual", "turn this into a graphic", "visualize this data", "infographic for X", "cheatsheet for X", or when the user provides structured data (tokenomics allocations, ecosystem/partner lists, timelines, comparisons, step-by-step processes) AND asks for a visual output. Covers tokenomics, ecosystem overviews, game overviews, cheatsheets, airdrop guides, comparisons, and process flows. Do NOT trigger for plain text answers, markdown tables, bulleted summaries, questions asking for advice or explanations about a topic (even when the topic is tokenomics, ecosystem, vesting, etc.), inline chat diagrams, or data processing with no visual output requested. The signal is "asks for a visual", not "mentions a keyword".

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Master modern Angular state management with Signals, NgRx, and RxJS. Use when setting up global state, managing component stores, choosing between state solutions, or migrating from legacy patterns.

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Modern Angular (v20+) expert with deep knowledge of Signals, Standalone Components, Zoneless applications, SSR/Hydration, and reactive patterns.

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This skill should be used when the user asks to "create AGENTS.md", "update AGENTS.md", "maintain agent docs", "set up CLAUDE.md", or needs to keep agent instructions concise. Enforces research-backed best practices for minimal, high-signal agent documentation.

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Answer Engine Optimization (AEO) skill — optimize content to be cited by AI language models (ChatGPT, Perplexity, Claude, Gemini, Mistral) as authoritative sources. Distinct from SEO — AEO optimizes for citation in LLM-generated responses, not search rankings. Use when planning content for AI-first search audiences, auditing existing content for E-E-A-T signals, tracking which pages get cited by which LLMs, or building a citation-friendly content strategy. Triggers — 'AEO audit', 'optimize for ChatGPT', 'get cited by Perplexity', 'LLM citation strategy', 'answer engine optimization', 'content for AI search', 'E-E-A-T audit'. Output is a markdown audit report (default) or JSON for pipeline integration. Stdlib-only Python tools.

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Act as a senior Amazon account growth operator that combines Amazon performance-drop analytics, Amazon growth-opportunity analytics, Amazon Ads data, retail readiness, BSR/rank signals, margin, inventory, and campaign/search-term evidence into a prioritized profitable growth action plan. Use when Codex needs to decide what to protect, fix, scale, reduce, pause, harvest, launch, or monitor for an Amazon brand, agency, marketplace, ASIN set, or account; when building daily, weekly, or monthly Amazon account operating plans; when reallocating ad budget; when deciding which ASINs are safe or risky to push; or when turning performance-drop and growth-opportunity findings into approval-gated actions with success/failure criteria.

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Use for read-first Amazon Sponsored Products optimization, product-aware growth, preflight readiness, and post-change monitoring reviews that can run standalone from static exports or use Rocketcart MCP as an optional Amazon Ads plus product-intelligence layer. Guides Codex to inspect Rocketcart profiles, live SP campaigns, product ads/ASIN context, category rank/BSR movement, competitor signals, product readiness, budget and targeting drift, snapshots/changelogs, and proposed approval-gated action rows without executing writes by default.

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Discover B2B leads from Reddit using AI-powered lead scoring via reddapi.dev Leads API. Finds high-intent signals, scores them 0-100, and classifies by lead type (pain_point, solution_request, complaint, feature_request, comparison). Perfect for competitor poaching, pain point discovery, and sales prospecting.

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Ultra-compressed code review comments. Cuts noise from PR feedback while preserving the actionable signal. Each comment is one line: location, problem, fix. Use when user says "review this PR", "code review", "review the diff", "/review", or invokes /caveman-review. Auto-triggers when reviewing pull requests.

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Separates signal from noise in metrics you cannot observe directly, updating a belief from evidence instead of reacting to the latest reading - Bayesian updates over competing explanations, and a filter that says whether this week's move is real. Use when a metric moves and someone wants to act, when diagnosing why traffic or revenue changed, when a dashboard number contradicts intuition, or when deciding whether a trend is real yet.

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Builds the "Report Sources" child page for a finished Weekly Community Signal report — an evidence-backed defense of WHY every item landed in the column/section/rank it did. The agent argues each placement like a lawyer (claim → evidence → rule → rebuttal) but is under oath: it CANNOT invent, spin, or overstate — every claim ties to a verifiable fact (issue #, label, PR type, quoted comment, npm output, the front-door test). Not CYA — it's so Nathan can defend the report with facts and see the exact reasoning behind each call. Runs after the report (invoked by weekly-report, last steps) and on "report sources", "defend the report", "why is this here".

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Enterprise-specific view across CopilotKit + AG-UI. "Enterprise" here = CopilotKit's COMMERCIAL surfaces (Premium / CopilotKit Enterprise / Intelligence Platform / paid tiers), NOT CopilotKit running inside a big company. Tracks the commercial product surfaces (from product-surface-scan — Enterprise Intelligence, Cloud, self-host license, threads/persistence tier, Inspector, premium UI/Angular SDK, analytics, security bundle, Slack/Teams), applies the free-vs-paid classifier to decide if an issue belongs here, surfaces cross-page product contradictions, and tracks enterprise questions/complaints, community-sourced prospects (with a sales owner), and enterprise reporters with prior-week trend. Elevated to the top of the weekly report. Runs standalone ("who's at enterprise this week") or invoked by weekly-report. Triggers on "enterprise report", "enterprise signals", "enterprise status", "who at enterprise this week".

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Generate the ≤10-minute Loom walkthrough script for a completed Weekly Community Signal report — a plain spoken briefing that dives straight into what the team needs to know, walking the report top to bottom (CopilotKit page first, then AG-UI in the same order). Straightforward and factual, NOT a radio show or a performance; no hype opener, no blame framing. Runs after every report (invoked by weekly-report) and on "loom script", "walkthrough script", "record the loom", "narrate the report".

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Expert-level neural engineering covering neural interfaces, brain-computer interfaces, neural signal processing, deep brain stimulation, and neuroprosthetics.

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Generate architecture and design documents for implemented code changes with risk-based depth selection. Automatically evaluates risk signals, layer spread, and change magnitude to choose documentation level (A/B/C). Use after completing a feature, before merging a PR that touches multiple layers or sensitive areas (auth, infra, migrations, payments), or when an implemented change needs a design record or ADR.

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Use before committing to a heavy or irreversible plan — imagine it's 6 months later and this failed; enumerate why, score each mode, derive early-warning signals and preventive guardrails.

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Use when shaping an engineering hiring loop — stages, take-home vs live, calibration, bar-raiser, signal-vs-noise audit. Triggers on 'design our interview loop', 'audit our hiring bar'.

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Use when designing monitoring dashboards — visualization selection, layout principles, observability strategies (RED/USE/Golden Signals), and data storytelling.

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Use when designing account-expansion mechanics — upsell vs cross-sell, expansion-trigger signals, NRR cognition. Triggers on 'lift NRR', 'when do we upsell vs cross-sell'.

日本語の概要は準備中です。原文の説明を表示しています。