「comprehensive」の検索結果

Integrate multiple ENCODE data types (RNA-seq, ATAC-seq, Histone ChIP-seq, TF ChIP-seq) for a tissue/cell type to build a comprehensive regulatory landscape. Use when the user wants to answer "what are the enhancers, promoters, and regulatory elements active in my tissue, and which transcription factors control them?" by layering expression, chromatin accessibility, histone marks, and TF binding data. Follows the Mawla et al. 2023 framework for cross-assay integration of islet cell type-specific data. Handles chromatin state annotation (ChromHMM), enhancer-gene linkage, TF motif enrichment, and cell type-specific regulatory element identification. Use for ANY multi-omic analysis, enhancer discovery, regulatory network construction, or epigenomic characterization using ENCODE data.

日本語の概要は準備中です。原文の説明を表示しています。

Build comprehensive chromatin contact maps by aggregating Hi-C loop calls (BEDPE) across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "what regions are in 3D contact in my tissue?" by creating a union catalog of chromatin loops. Handles resolution-aware anchor matching, cross-lab variation, and Hi-C-specific quality metrics.

日本語の概要は準備中です。原文の説明を表示しています。

Track exact provenance for every operation on ENCODE data — tool versions, reference files, scripts, parameters, and timestamps — to enable publication-ready methods writing. Use when the user processes ENCODE files, runs any bioinformatics tool, creates filtered/merged datasets, runs pipelines, performs liftover, uses R/Python/Bash for analysis, or needs to document their analysis chain for reproducibility and publication. Also use when the user says "write me methods" to auto-generate methods sections from the provenance log. This skill implements comprehensive provenance documentation: every tool, every version, every reference file, every parameter, every accession — no shortcuts. Use this skill for ANY processing step, ANY file transformation, ANY analysis operation on ENCODE data.

日本語の概要は準備中です。原文の説明を表示しています。

Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data into tissue-level methylation profiles. Handles coverage filtering, identifies hypomethylated regions (HMRs) and partially methylated domains (PMDs), and manages cross-lab variation.

日本語の概要は準備中です。原文の説明を表示しています。

Build comprehensive epigenomic profiles for tissues or cell types using ENCODE data. Use when the user wants to characterize chromatin states, assemble histone modification panels, create epigenomic landscapes, run ChromHMM segmentation, identify super-enhancers or bivalent domains, profile regulatory elements across a biosample, or understand epigenetic regulation in a specific biological context. Covers histone marks, chromatin accessibility, TF binding, transcription, DNA methylation, and 3D genome structure.

日本語の概要は準備中です。原文の説明を表示しています。

Build comprehensive histone mark maps by aggregating narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is this histone mark present in my tissue?" by combining peak calls from multiple studies into a union peak set with confidence annotations. Handles cross-lab batch effects, broad vs narrow marks, and ENCODE blocklist filtering.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive guide for visualizing ENCODE data including deeptools heatmaps, IGV screenshots, UCSC track hubs, and publication-quality plots. Use when users need to create visualizations of ChIP-seq signal, peak landscapes, genome browser views, or any visual representation of ENCODE data. Trigger on: heatmap, visualization, genome browser, track hub, IGV, deeptools, signal plot, peak visualization, profile plot, publication figure, bigWig visualization.

日本語の概要は準備中です。原文の説明を表示しています。

Build comprehensive chromatin accessibility maps by aggregating ATAC-seq and DNase-seq narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is chromatin accessible in my tissue?" by combining peak calls into a union peak set. Handles cross-lab variation, ATAC vs DNase platform differences, and ENCODE blocklist filtering.

日本語の概要は準備中です。原文の説明を表示しています。

Synthesize project documentation and codebase into comprehensive roadmap status, gaps analysis, and blockers. Use when assessing project health, identifying blockers, tracking progress, comparing plan vs reality, documenting risks, or planning next milestones. Triggers: "roadmap", "project status", "blockers", "risks", "progress", "next milestone", "gaps", "what's done".

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive UI/UX design review with live environment testing, responsive validation, accessibility compliance (WCAG 2.1 AA), and visual consistency analysis using Playwright. Use when user runs /design-review, /review:design-review, requests a "design review", "UI review", "UX audit", or mentions "review the design", "check accessibility", "responsive testing".

日本語の概要は準備中です。原文の説明を表示しています。

Master defensive Bash scripting for production automation, CI/CD pipelines, and system utilities. Expert in safe, portable, and testable shell scripts with POSIX compliance, modern Bash 5.x features, and comprehensive error handling. Use when writing shell scripts, bash automation, CI/CD scripts, system utilities, or mentions "bash", "shell script", "automation", "defensive programming", or needs production-grade shell code.

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Comprehensive SEO analysis for any website or business type. Orchestrates 52 sub-skills (52 active): full site audits, technical SEO (CWV/INP), schema, E-E-A-T content quality, images, sitemaps, GEO for AI Overviews, llms.txt generation, AI crawler audit, plus live GSC and Ahrefs MCP data. GSC: overview, drops, opportunities, brand-vs-nonbrand, cannibalization, compare, content-decay, index-issues, new-keywords. Ahrefs: overview, backlinks, keywords, competitors, content-gap, broken-links, new-links, anchor-analysis, dr-history, top-pages. Cross-MCP: serp, content-brief, brand-radar, site-audit-pro, report. Local: log-analysis, ai-content-check, internal-links, local, migration-check, obsidian-kb. AI Readability: llms-txt, robots-ai. Performance: lighthouse-audit, core-web-vitals, page-experience. Quality & AI Search: rich-results, ai-optimization, eeat-audit, helpful-content. Triggers on: "SEO", "audit", "schema", "Core Web Vitals", "sitemap", "E-E-A-T", "AI Overviews", "GEO", "technical SEO", "content quality", "structured data", "GSC", "Ahrefs", "backlinks", "keywords", "search console", "domain rating", "local SEO", "migration", "lighthouse", "pagespeed", "LCP", "INP", "CLS", "page experience", "interstitials", "mobile friendly", "rich results", "rich snippets", "schema eligibility", "AI optimization", "AI search readiness", "EEAT", "trust signals", "helpful content", "people-first", "content quality gate".

日本語の概要は準備中です。原文の説明を表示しています。

Generate comprehensive OpenSpec specifications directly from the current project state. Use when the user wants to create or populate main specs by analyzing existing code, documentation, AGENTS.md, GitHub issues, and pull requests — without going through the change/proposal workflow. Ideal for bootstrapping specs on a project that already has working code but no specs yet, or for refreshing specs to match the current implementation.

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Comprehensive guide for building, configuring, customizing, and deploying Docsify documentation sites. Use when the user wants to (1) initialize a new Docsify site, (2) add or organize Markdown pages, sidebars, navbars, or cover pages, (3) configure `window.$docsify` options, (4) customize themes / CSS variables / fonts, (5) install built-in or third-party Docsify plugins (search, GA, emoji, zoom, copy-code, comments, pagination, tabs, etc.), (6) write a custom Docsify plugin using lifecycle hooks, (7) use Docsify Markdown helpers (callouts, link attributes, image attributes, heading IDs, task lists, embed files with `:include`), (8) deploy to GitHub Pages, GitLab Pages, Netlify, Vercel, Firebase, Docker, Nginx, etc., (9) enable PWA / offline mode, virtual routes, or Vue compatibility, or (10) upgrade a Docsify site from v4 to v5. Triggers on mentions of "docsify", "_sidebar.md", "_navbar.md", "_coverpage.md", "$docsify", or `docsify-cli`.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive index for Tauri framework development, including Rust backend, frontend integration, and full plugin ecosystem. Acts as a router to specialized sub-skills with local examples and templates.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive project planning, requirements analysis, and architectural orchestration for Tauri 2.0 applications.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive security audit covering OWASP Top 10, secrets detection, supply chain security, threat modeling, and language-specific vulnerability patterns. Investigates actual code paths rather than grep-matching keywords. Generates a scored SECURITY_AUDIT.md with prioritized remediation. Use when assessing application security, preparing for a security review, or onboarding to a codebase with security concerns.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive code review using specialized agents — orchestrates code, comments, tests, errors, types, and simplify agents sequentially.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive healthcare system compliance and security audit: review HIPAA Privacy and Security Rule adherence, check HITECH and 21st Century Cures Act obligations, validate clinical data integrity for HL7 FHIR and patient safety.

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive K-12 or higher-ed system analysis: predict student dropout risk with early warning indicators, optimize curriculum alignment and pacing, personalize learning paths for at-risk and diverse populations, and audit school operations for resource efficiency..

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive 2026 SEO audit covering classic technical SEO (crawl, render, index, Core Web Vitals with INP), on-page (titles, meta, headings, internal linking), content (topical authority, entity density).

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive SEO analysis for any website or business type. Full site audits, single-page analysis, technical SEO (crawlability, indexability, Core Web Vitals with INP), schema markup, content quality (E-E-A-T), image optimization, sitemap analysis, and GEO for AI Overviews/ChatGPT/Perplexity. Industry detection for SaaS, e-commerce, local, publishers, agencies. Triggers on: SEO, audit, schema, Core Web Vitals, sitemap, E-E-A-T, AI Overviews, GEO, technical SEO, content quality, page speed. Use this hub only when the SEO domain is clear and the requested workflow is not; otherwise use the exact retained leaf or command.

日本語の概要は準備中です。原文の説明を表示しています。

Migrates Android applications from the old, legacy Google Mobile Ads (GMA) SDK (com.google.android.gms:play-services-ads) to the new GMA Next-Gen SDK (com.google.android.libraries.ads.mobile.sdk:ads-mobile-sdk). Provides comprehensive mapping tables for imports, classes, and method signatures to help determine migration steps. Use when migrating an existing Android codebase from the old, legacy GMA SDK to GMA Next-Gen SDK.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrates comprehensive production readiness reviews and assessments for GKE clusters and workloads across scalability, security, reliability, observability, backup/DR, and cost optimization. Use when asked to productionize, prepare, assess, audit, or review a GKE cluster or workload before going live to production. Don't use for deep-dive single-domain implementation (use specific domain skills like gke-workload-scaling, gke-platform-security, gke-workload-security, gke-service-networking, gke-reliability instead).

日本語の概要は準備中です。原文の説明を表示しています。