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Use when edit_blueprint.yaml and selects_candidates.yaml are ready and the user asks to compile the rough cut, generate timeline.json, or apply a review patch.

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Implement a task N ways in parallel and pick the best. Spawns multiple subagents in isolated worktrees, evaluates all candidates, and applies the winner. Use when asked to "best of n", "try multiple approaches", "parallel implementations", "/best-of-n", or "/bon".

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Create PostHog error tracking suppression rules to drop high-volume, low-value errors at ingestion. Use when the user asks "stop capturing this error", "drop browser extension errors", "ignore ResizeObserver loops", "suppress bot-driven errors", or wants to reduce ingestion cost from noisy unactionable errors. Identifies suppression candidates, scopes the filter tightly, decides between full suppression and sampling, and confirms the rule before creating it. Suppressed errors are dropped permanently — this skill defaults to caution.

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Take a markdown file of raw material and shape it into an article through a conversational session — drafting candidate openings, growing the piece paragraph by paragraph, arguing about format (lists, tables, callouts, quotes) at each step. Use when the user has a pile of notes, fragments, or a rough draft and wants help turning it into something publishable.

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Use for Vercel cost and performance optimization on deployed projects, especially Next.js, SvelteKit, Nuxt, and limited Astro apps. Collect Vercel metrics, usage, project config, and code scan results first; investigate only metric-backed candidates; produce ranked recommendations grounded in verified files and version-aware Vercel/framework docs. Trigger for Vercel bill reduction, slow or expensive routes, caching opportunities, Function Invocations, Build Minutes, Fast Data Transfer, Core Web Vitals, Bot Management, Fluid compute, or cost breakdown requests.

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Follow-up scout for the Signals inbox itself. Watches reports that recently transitioned to resolved (an implementation PR merged) and, after a deployment soak window, re-measures the underlying problem to check the fix actually held — plus a strictly-gated escalation check on recently dismissed reports. Emits findings only when a shipped fix demonstrably didn't hold; confirmations and unverifiable verdicts become durable memory and an empty close-out. Self-contained peer in the signals-scout-* fleet — no dependencies on other skills.

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Diagnose why a product metric changed (dropped, spiked, or plateaued) by orchestrating breakdowns, actors, paths, lifecycle, retention, and annotations queries. Use when the user reports an anomaly, asks "why did X change?", or needs root-cause analysis for a trend, funnel, retention, stickiness, or lifecycle metric.

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Investigates a session recording by gathering metadata, person profile, same-session events, and linked error tracking issues in one pass. Use when a user provides a recording or session ID and wants to understand what happened — who the user was, what they did, what errors occurred, and whether there are related error tracking issues. Replaces the manual chain of session-recording-get, persons-retrieve, execute-sql, and query-error-tracking-issues-list.

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Investigate LLM spend in PostHog — total cost over time, cost by model, provider, user, trace, or custom dimension, token and cache-hit economics, and cost regressions. Use when the user asks "how much are we spending on LLMs?", "which model / user / feature is most expensive?", "why did cost spike?", wants to build a cost dashboard or alert, or pastes a trace URL and asks about its cost.

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How to explore and make sense of PostHog Signals scouts — the scheduled agents that scan a project and emit findings into the Signals inbox. Use when a user wants to understand what scouts they have, how each one is behaving, and whether the fleet is actually working. Covers surveying the fleet and its schedules, reading recent scout runs and drilling into a single run's reasoning, inspecting the durable scratchpad memory the fleet has built up, tracing a run to the findings it emitted, and assessing a scout's health and performance over time (cadence, success rate, emit rate, signal-to-noise). Read-only and exploratory — to write or tune a scout, use `authoring-signals-scouts` instead. Trigger on "what are my scouts doing", "how is my <x> scout performing", "show me recent scout runs", "why did this scout find/emit nothing", "what has the fleet learned", "explore scout run <id>", "is my scout working".

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Write reusable ChatCrystal task memories after substantive work completes. Use when implementation or debugging produced a durable fix, pitfall, pattern, or decision worth preserving, and when the environment can either persist it through `write_task_memory` or emit a structured memory candidate for later save.

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End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vaccine design or checkpoint biomarkers.

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Selects biomarker features from high-dimensional omics data using Boruta all-relevant selection, mRMR, LASSO/elastic-net, and stability selection, while controlling the leakage, irreproducibility, and correlated-feature traps that make most published signatures fail to replicate. Use when identifying candidate biomarkers, deciding between an all-relevant and a minimal-optimal selector, or judging whether a selected gene set is reproducible. For unbiased performance estimation of the resulting model see machine-learning/model-validation; for interpreting a trained model see machine-learning/prediction-explanation.

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Authors reproducible bioinformatics pipelines with Snakemake - rules wired by output-file pattern, wildcards and expand() for sample fan-out, checkpoints for runtime-unknown outputs, resource/retry escalation, and conda/container software deployment on HPC and cloud. Use when deciding rule-based (Snakemake) vs channel/dataflow (Nextflow) authoring; wiring rules by OUTPUT-file pattern rather than imperative order; using wildcards + expand() for sample fan-out and constraining them to stop silent mis-routing; adding checkpoints when the set of outputs is unknown until a step runs (dynamic DAG); diagnosing why a job reran (or did not) under the mtime-plus-provenance trigger set; escalating memory on retry for OOM-killed jobs; and porting a Snakemake 7 `--cluster`/remote-provider command to the Snakemake 8+ executor-plugin and storage-plugin model (snakemake-executor-plugin-slurm) with `--software-deployment-method`.

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End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene prioritization (L2G / PoPS / cS2G), and GenomicSEM common-factor GWAS. Use when triangulating causal inference across multiple complementary methods, prioritizing tissues via stratified LDSC, nominating or de-risking drug targets, mapping a lead SNP to a candidate effector gene, modeling shared genetic architecture across correlated traits, or producing a STROBE-MR-compliant publication-grade evidence battery from GWAS summary statistics.

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Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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ADMET property prediction for drug candidates. Full pharmacokinetic panel (Caco-2, PPB, clearance, CYP), toxicity (hERG, AMES, DILI), drug-likeness (Lipinski, QED), using RDKit descriptors and TDC models.

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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.

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Benchmark stellar-build skills to measure quality and the lift from optimization. Use when the user says "bench my skills", "bench-skills", "benchmark skills", "did optimization help", "measure my skills", "stellar-loop bench", or wants to quantify whether /optimize-skills actually improved things. Held-out eval prompts scored by an LLM judge, reproducible with fixed seeds. Fully local.

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Extract candidate name, contact details, work history, and skills from resumes.

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Extract candidate information from a resume PDF, then generate a formatted employee profile document for HR onboarding.

日本語の概要は準備中です。原文の説明を表示しています。

Convert a resume PDF to clean markdown for LLM parsing or candidate pipelines.

日本語の概要は準備中です。原文の説明を表示しています。

Entry-point router skill for the 1Password CLI. Use this skill when the user mentions the 1Password CLI (`op`) or 1Password generically, references the secret-reference URI scheme `op://`, asks about `OP_ACCOUNT` or `OP_SERVICE_ACCOUNT_TOKEN`, asks about biometric unlock for a CLI, or is choosing how to load secrets into an app and 1Password is a candidate. Provides general orientation, the auth-mode picker, the full command map, and routing to deeper sub-skills (`op-secrets-injection`, `op-item-management`, `op-provisioning`, `op-ssh-keys`, `op-shell-plugins`, `op-service-accounts`). Defer to those sub-skills for specific commands.

日本語の概要は準備中です。原文の説明を表示しています。