「experiment」の検索結果

Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Archive a completed change in the experimental workflow. Use when the user wants to finalize and archive a change after implementation is complete.

日本語の概要は準備中です。原文の説明を表示しています。

The original v1 taste-skill, preserved for projects depending on its exact behavior. The current default is `design-taste-frontend` (v2 experimental), which is a substantial rewrite. Use this v1 install name only if you need exact backward compatibility.

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Use when designing experiments for subject lines, offers, cadences, or journeys.

日本語の概要は準備中です。原文の説明を表示しています。

Expert in statistical analysis for blind A/B and ABX audio testing. Validates randomization, calculates statistical significance, and ensures proper experimental design. Use when implementing A/B test features or analyzing test results.

日本語の概要は準備中です。原文の説明を表示しています。

Design and analyze A/B tests, calculate statistical significance, and determine sample sizes for conversion optimization and experiment validation

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Azure Weights & Biases SDK for .NET. ML experiment tracking and model management via Azure Marketplace. Use for creating W&B instances, managing SSO, marketplace integration, and ML observability.

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Archive a completed change in the experimental workflow. Use when the user wants to finalize and archive a change after implementation is complete.

日本語の概要は準備中です。原文の説明を表示しています。

Start a new OpenSpec change using the experimental artifact workflow. Use when the user wants to create a new feature, fix, or modification with a structured step-by-step approach.

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Track ML experiments with automatic logging, visualize training in real-time, optimize hyperparameters with sweeps, and manage model registry with W&B - collaborative MLOps platform

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Use a live Jupyter kernel for stateful, iterative Python execution via hamelnb. Load this skill when the task involves exploration, iteration, or inspecting intermediate results — data science, ML experimentation, API exploration, or building up complex code step-by-step. Uses terminal to run CLI commands against a live Jupyter kernel. No new tools required.

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Debug LLM applications using the Phoenix CLI. Fetch traces, analyze errors, review experiments, inspect datasets, and query the GraphQL API. Use when debugging AI/LLM applications, analyzing trace data, working with Phoenix observability, or investigating LLM performance issues.

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Launch new products from idea to first customers. Use when launching products, finding early adopters, building launch week playbooks, diagnosing why adoption stalls, or learning that press coverage does not equal growth. Includes the three-layer diagnosis, the 2-week experiment cycle, and the launch that got 50K impressions and 12 signups.

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Write ML papers for NeurIPS/ICML/ICLR: design→submit.

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Build features guided by data insights, A/B testing, and continuous measurement using specialized agents for analysis, implementation, and experimentation.

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Builds WinForms on .NET 8+. High-DPI, dark mode (experimental), DI patterns, modernization.

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Static-to-EDS conversion that preserves the original design while making content authorable in Document Authoring. Two modes — page-level (overlay template with slot markers) and block-level (each section becomes an independent EDS block). Use when converting an AI-generated static HTML page (Stardust, Mobirise, Relume, Lovable, v0, Figma-derived hand-coded, etc.) into an Edge Delivery Services page. Triggers on "convert this page to EDS", "static-to-EDS overlay", "convert to EDS blocks", "next experimentation", "next run", "start run", or when a user provides a source URL and asks to make it editable in DA while keeping the original design intact. Do NOT use for canonical EDS block-rewrite migrations — that's the page-import skill.

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Analyze source data, tables, CSV/XLSX extracts, metrics, or experiment results with explicit data-authenticity checks. Use for profiling, cleaning assumptions, statistical summaries, segmentation, trend analysis, or "analyze this data"; do not use for spreadsheet file surgery, chart design only, database migrations, or claims without data provenance.

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Design, validate, and plan a startup from scratch. Covers market research, competitive analysis, business model, brand identity, product definition, financial projections, and validation experiments. Trigger when the user has a startup idea to explore, wants to validate a business concept, needs a business plan or lean canvas, asks for market sizing or competitive landscape, wants brand positioning or go-to-market strategy, or says anything like "I have an idea for..." or "is this idea worth pursuing". Also handles resuming from a previous checkpoint.

日本語の概要は準備中です。原文の説明を表示しています。

The original v1 taste-skill, preserved for projects depending on its exact behavior. The current default is `design-taste-frontend` (v2 experimental), which is a substantial rewrite. Use this v1 install name only if you need exact backward compatibility.

日本語の概要は準備中です。原文の説明を表示しています。