「hie」の検索結果

Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Infer orthologous genes and gene families across species using OrthoFinder3 (HOG-based phylogenetic orthology), SonicParanoid2, Broccoli, ProteinOrtho, OMA / FastOMA hierarchical orthologous groups, eggNOG-mapper, JustOrthologs, and TOGA whole-genome-alignment orthology. Use when building single-copy ortholog sets for phylogenomics, classifying co-orthologs and in/out-paralogs after gene duplication, propagating functional annotation via orthology with awareness of the ortholog conjecture, distinguishing speciation from duplication via gene-tree species-tree reconciliation, computing Quest-for-Orthologs benchmark performance, or running synteny-aware ortholog detection in WGD-affected lineages.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Evaluate design from a UX perspective, assessing visual hierarchy, information architecture, emotional resonance, cognitive load, and overall quality with quantitative scoring, persona-based testing, and actionable feedback. Use when the user asks to review, critique, evaluate, or give feedback on a design or component.

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Azure Data Lake Storage Gen2 SDK for Python. Use for hierarchical file systems, big data analytics, and file/directory operations.

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Algorithmic philosophies are computational aesthetic movements that are then expressed through code. Output .md files (philosophy), .html files (interactive viewer), and .js files (generative algorithms).

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Testing and benchmarking LLM agents including behavioral testing, capability assessment, reliability metrics, and production monitoring—where even top agents achieve less than 50% on real-world benchmarks

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Warm editorial, print-leaning document design system — parchment background, single ink-blue accent, serif-led hierarchy (LXGW WenKai for Chinese, Charter for English). For résumés, reports, white papers, letters, and editorial reading pages that should feel authored and published. Not a product-UI / component system.

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Dark-themed cloud-platform aesthetic with modular grids, glass-like panels, and strong data hierarchy for productivity dashboards.

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Modular grid layout with card-like blocks, clear hierarchy, soft spacing, and subtle visual contrast for organized, scannable interfaces.

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Audita criativo antes da aprovação — contraste, legibilidade, área segura, hierarquia, aderência ao brand kit e conformidade. Use quando o usuário disser "revisar a peça", "está bom?", "checar o criativo", "auditar", "pode publicar?", ou automaticamente após qualquer montagem. É portão de saída: peça que não passa não vai para 04 — Aprovado.

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Traduz copy aprovada em conceito visual — ideia central, hierarquia, sistema de peças e especificação de ativos. Use quando o usuário disser "como fica visualmente", "conceito da campanha", "direção de arte", "qual a ideia da peça", "transformar a copy em criativo", ou antes de montar qualquer coisa no Figma. É a ponte entre pwdev-copy e a produção.

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Monta carrossel completo — estrutura de slides, hierarquia por slide e construção no Figma como componente com variantes. Use quando o usuário disser "carrossel", "slides", "carrossel do LinkedIn", "carrossel do Instagram", "post em sequência", "documento do LinkedIn". Recebe a copy slide a slide e entrega frames montados e revisados.

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Otimiza a estrutura e a conversão de páginas de marketing — hierarquia, ordem das seções, posicionamento de CTA, sinais de confiança e pontos de atrito. Use quando o usuário disser "CRO", "essa página não converte", "melhorar conversão", "por que ninguém clica", "otimizar a landing". Cuida de estrutura; para reescrever o texto ver copy-page.

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Designer's eye QA: finds visual inconsistency, spacing issues, hierarchy problems, AI slop patterns, and slow interactions — then fixes them. Iteratively fixes issues in source code, committing each fix atomically and re-verifying with before/after screenshots. For plan-mode design review (before implementation), use /plan-design-review. Use when asked to "audit the design", "visual QA", "check if it looks good", or "design polish". Proactively suggest when the user mentions visual inconsistencies or wants to polish the look of a live site. (gstack)

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Chief Security Officer mode. Infrastructure-first security audit: secrets archaeology, dependency supply chain, CI/CD pipeline security, LLM/AI security, skill supply chain scanning, plus OWASP Top 10, STRIDE threat modeling, and active verification. Two modes: daily (zero-noise, 8/10 confidence gate) and comprehensive (monthly deep scan, 2/10 bar). Trend tracking across audit runs. Use when: "security audit", "threat model", "pentest review", "OWASP", "CSO review". (gstack) Voice triggers (speech-to-text aliases): "see-so", "see so", "security review", "security check", "vulnerability scan", "run security".

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Scan an AEM Edge Delivery Services page for WCAG 2.1 AA accessibility violations and generate specific fixes. Identifies missing alt text, heading hierarchy issues, link text problems, color contrast concerns, and EDS-specific accessibility patterns. Use when fixing accessibility issues, preparing for compliance audits, or remediating WCAG violations.

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Elite mobile app image-generation skill for creating premium, app-native screen concepts and flows. Designed for iOS, Android, and cross-platform mobile products. Prioritizes clean hierarchy, comfortably readable text, strong multi-screen consistency, controlled color palettes, non-generic creative direction, textured surfaces, image-led composition, tasteful custom iconography, and clean phone mockup framing. By default, screens should be shown inside a subtle premium iPhone or similar phone mockup with a visible frame, while the main focus stays on the app content itself. This skill generates images only. It does not write code.

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Security audit orchestrator for agent skills — scans for prompt injection, data exfiltration, credential theft, supply chain risks, and instruction hierarchy violations before any skill is installed, created, improved, or read from a GitHub repo. Load when creating skills from external sources, when improve-skills reads from GitHub repos, when research-skill fetches community SKILL.md files, when a user installs a third-party skill, or when the user asks to audit skill security, scan for injection, check if a skill is safe, scan all skills, or run a security sweep. Orchestrates all secure-* skills in sequence. Content is SAFE only if ALL secure-* skills return SAFE. 36% of community skills contain flaws (Snyk ToxicSkills 2026). This skill is the first line of defense.

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Runtime security for agent skills — prevents state corruption, skill overwrite attacks, denial of service, and enforces provenance tracking and no-go repo management. Load as part of the secure-* skill sequence whenever an agent processes external content or writes to the skill store. Also load when the user asks to check for state corruption, prevent skill overwrite, manage no-go repos, check provenance, audit runtime security, detect DoS patterns, or protect the skill store. Covers Issues 6, 9, 10 from the agent security threat model: instruction hierarchy enforcement, state corruption and skill overwrite, and denial of service prevention.

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Analyzes job descriptions and generates tailored resumes that highlight relevant experience, skills, and achievements to maximize interview chances

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These are instructions for creating design philosophies - aesthetic movements that are then EXPRESSED VISUALLY. Output only .md files, .pdf files, and .png files.

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Azure Data Lake Storage Gen2 SDK for Python. Use for hierarchical file systems, big data analytics, and file/directory operations.

日本語の概要は準備中です。原文の説明を表示しています。