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概要と使いどころ
Harmony batch correction for scRNA-seq and other omics. Removes batch effects from PCA embeddings while preserving biology. Run after PCA, before UMAP. Scales to millions of cells. Python (harmonypy, scanpy) and R (Seurat).
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Deep generative models for single-cell omics: probabilistic batch correction (scVI), semi-supervised annotation (scANVI), CITE-seq RNA+protein (totalVI), transfer learning (scARCHES), and DE with uncertainty. Unified setup→train→extract API on AnnData. Use harmony-batch-correction for fast linear correction without deep learning; muon for multi-modal MuData workflows.
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JASPAR 2024 TF binding profiles via REST API and pyJASPAR. Retrieve PFMs/PWMs by TF name, JASPAR ID, species, or structural class. Scan DNA for TFBS; browse by taxon (human, mouse) or TF family (bHLH, zinc finger). Use for motif enrichment input, TFBS scanning, and regulatory sequence analysis. For ChIP-seq peak motif discovery use homer-motif-analysis; for regulatory variant scoring use regulomedb-database.
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Consensus cell type annotation: runs 10+ algorithms (KNN-Harmony/BBKNN/Scanorama/scVI, CellTypist, ONCLASS, Random Forest, SCANVI, SVM, XGBoost) on a labeled reference and transfers labels via majority voting. Outputs per-method labels, consensus, agreement score. Use when single-method annotation is insufficient or you need ensemble uncertainty for novel states.
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scRNA-seq with Scanpy: QC, normalization, HVG selection, PCA, neighborhood graph, UMAP/t-SNE, Leiden clustering, markers, cell annotation, trajectory inference. Standard scRNA-seq exploration.
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Scaffold a new SciAgent-Skills entry. Picks pipeline/toolkit/database/guide template, creates skills/{category}/{name}/SKILL.md with valid frontmatter, appends the registry.yaml entry, runs validation. Enforces name uniqueness, kebab-case, description keyword rules, schema rules from AGENTS.md. TRIGGER when user says (any language): "add a SciAgent skill", "add a skill for <X>", "create new skill", "create a SKILL.md for <X>", "scaffold a skill", "new skill entry", "register a skill", "신규 skill 추가", "스킬 만들어줘", "스킬 생성", "skill 만들어", or any request to add a new SKILL.md to this repo. ALWAYS invoke this skill BEFORE writing to skills/ or registry.yaml. DO NOT TRIGGER when: editing existing entry's content (just edit the file directly); migrating an existing entry (read AGENTS.md "Migrating from Existing Entries" first); only updating registry.yaml without creating a new SKILL.md.
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Scan stocks for Poor Man's Covered Call (PMCC) suitability. Analyzes LEAPS and short call options for delta, liquidity, spread, IV, yield, trend direction, and earnings proximity. Use when user asks about PMCC candidates, diagonal spreads, or LEAPS strategies.
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Turn Chinese classical poems and ci into coherent vertical Chinese-art videos with poem-driven scene grouping, GPT ImageGen stills, Docker-only Gemini I2V, retained model-generated ambience, Gemini sparkle-watermark cleanup, brush-calligraphy captions revealed character by character, optional local BGM mixing, stitching, and final-frame QA. Supports verse-driven variation across ink landscape, gongbi bird-and-flower, colored figure-and-horse painting, blue-green landscape, xuan paper, silk, and related Chinese visual languages. Use when users ask for 古诗词动态视频、诗词逐句或两句一景、国风视频、毛笔字逐字出现、整首诗拼接成片，or want the established 月落乌啼霜满天 workflow applied to another poem.
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Provides AWS CloudFormation patterns for ECS clusters, task definitions, services, container definitions, auto scaling, blue/green deployments, CodeDeploy integration, ALB integration, service discovery, monitoring, logging, template structure, parameters, outputs, and cross-stack references. Use when creating ECS clusters with CloudFormation, configuring Fargate and EC2 launch types, implementing blue/green deployments, managing auto scaling, integrating with ALB and NLB, and implementing ECS best practices.
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Apply price escalation to CWICR estimates over time. Calculate inflation adjustments, material price indices, and labor rate increases.
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Build a complete typographic system -- modular or fluid type scale, line-height and tracking per size, weight roles, and vertical rhythm -- exported as tokens, Tailwind config, and CSS. Pairs with font-pairing-suggester (which picks the fonts; this builds the system they live in).
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Use to run real static analysis over a diff or repo before shipping — Semgrep, CodeQL, secret scanning, dependency CVEs — and triage the findings into what must be fixed now versus noise. Trigger before a release or PR merge, during a security review, or when the user asks to scan the code for vulnerabilities.
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Pulls financial statement numbers for US public companies straight from SEC EDGAR's free official XBRL APIs (companyfacts, companyconcept, frames, submissions) into a cited table. Every value carries its accession number, form, fiscal period, filed date, XBRL tag and a link to the filing, and the tool handles fiscal-year ends, quarterly vs YTD vs TTM, derived Q4, restatements and units. Use this whenever the user wants 10-K numbers or 10-Q numbers, says "pull financials for", asks for public company revenue, net income, EPS, cash, debt or capex, wants comps or a competitor side-by-side, a credit check, prospect research, or model inputs, or mentions SEC filings or EDGAR, even if they never say XBRL. Free and primary-source, no paid data terminal needed. Do not use it for private companies, stock prices or valuation multiples.
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Deep-scan any tools you connect (CRM, email, support, reviews, analytics, billing, database) to produce a data-grounded Ideal Customer Profile and a reusable persona library. Read-only by default. Use when you need to define or refresh your ICP, build buyer personas from real data instead of guesses, or generate the persona inputs that the customer-panel-of-experts and prospect-panel-simulator skills consume.
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Runs a three-tier codebase audit (git history, targeted scans, full review) with gating. Use when auditing a codebase before release or after incidents.
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Cascades a rebase through an entire PR stack after a base PR merges or upstream changes. Use when a stack needs to incorporate new base branch commits.
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Provides review-workflow scaffolding for context, evidence, and output. Use at the start of any detailed review to ensure consistent, comparable findings.
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Assesses decision reversibility and risk at critical checkpoints. Use when a workflow reaches a high-stakes branch needing escalation check.
日本語の概要は準備中です。原文の説明を表示しています。
Applies data-grid architecture for high-traffic stateful workloads. Use when a single database cannot scale and in-memory partitioning is needed.
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ICS/SCADA/OT exploitation - Modbus (502), S7comm (102), EtherNet/IP (44818), DNP3, OpenPLC, Node-RED SCADA, PLC/HMI/coil/holding-register attacks. Use when a target exposes industrial protocols or the goal is to drive a plant to a dangerous state (over-pressure/over-speed/disable interlock) and read the flag the HMI/CCTV reveals.
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Local Windows privilege escalation on a STANDALONE / workgroup host, or a local shell on a domain member - foothold to SYSTEM. Token privileges (SeImpersonate/Potato), service misconfig (weak perms / unquoted path / writable binary), registry autologon creds, scheduled-task + writable-script abuse, DLL hijack, AlwaysInstallElevated, UAC bypass, credential loot. For DOMAIN escalation (kerberoast/DCSync/ADCS/BloodHound) use hunt-ad instead. Wiki-first, FIND schema output.
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Autonomous sub-agent hand-off for a fiddly, fully-specified exploit-compile / escalation RUN - the main agent stays on strategy and the board while a cheap sub-agent runs an exact copy-paste checklist behind a false-root/hostname guardrail. Use for "delegate", "offload", "hand this to a sub-agent", "spin a haiku", or the moment a foothold plus a working escalation vector is identified. Main agent dispatches, waits (no parallel duplicate), integrates the result.
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Refresh the user's competitive and market context. Re-scan named rivals and the category for what changed since the brief was written (rebrands, repositioning, new entrants, pricing shifts, renamed categories) and update docs/gtm-cofounder/founder-brief.md and the roadmap with anything that moves positioning. Use on a cadence, or whenever a competitor rebrands, a new tool appears, or the user senses the market has shifted under them.
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This skill should be used when the user asks to "write a poem", "write a limerick", "write a sonnet", "haiku", "villanelle", "ballad", "song lyrics", "a song for my character", "a rhyme", "rhyming couplets", "does this scan", "check the meter", "fix the rhythm of this poem", "rhyme scheme", "iambic pentameter", "a prophecy in verse", "a nursery rhyme", "rhyming picture book", or wants verse written, scanned, or revised, whether inside a story project or as a standalone poem. NOT for accidental rhymes in prose (use line-editing) or permissions for quoting someone else's poem or song lyrics (use editorial-review).
日本語の概要は準備中です。原文の説明を表示しています。