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概要と使いどころ
Run one task through the V-model verification loop: CP-2 plan → CP-3 build → CP-3v component verify → CP-4 integration verify (full lane) → CP-5 acceptance. The worker never grades its own homework; evidence rows trace back to AC-n. Opt-in: invoke with /closed-loop or by asking for the closed loop, proper verification, or an evidence trail. Ordinary work does not run this.
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Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends AIPex's capabilities with specialized knowledge, workflows, or tool integrations.
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Review generated or changed WooCommerce code — extensions, payment and shipping integrations, checkout customizations, and order/product logic — before it ships. Best used reactively after an agent writes, edits, or reviews code touching WooCommerce APIs: wc_get_order, wc_get_orders, wc_get_product, WC() cart or session, woocommerce_* hooks, Store API endpoints, payment gateways, order or product meta, HPOS, subscriptions, or bookings. Use on 'review this Woo plugin', 'is this HPOS compatible', or after tasks like 'write a WooCommerce extension', 'add a checkout field', 'hook into the order flow', or 'update stock'. Enforces HPOS-safe order access, CRUD over direct meta, feature-compatibility declarations, server-side checkout validation, money-handling discipline, and hooks over template overrides. DO NOT USE for WordPress code without WooCommerce APIs (use wp-guard), generic code review (use clean-code-guard), test review (use test-guard), or store configuration and admin-screen questions.
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Use when systematically gathering, coding, and synthesizing a management/organization literature for an Academy of Management Annals (Annals) review — the search-and-coverage methodology and the choice of narrative vs. systematic vs. bibliometric integration. Builds the corpus and synthesis notes; it does not impose the organizing spine (amann-organizing-framework) or write prose.
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Generates an x-ray.md pre-audit report covering overview, enhanced threat model (protocol-type profiling, git-weighted attack surfaces, temporal risk analysis, composability dependency mapping), invariants, integrations, docs quality, test analysis, and developer/git history. Triggers on 'x-ray', 'audit readiness', 'readiness report', 'pre-audit report', 'prep this protocol', 'protocol prep', 'summarize this protocol'.
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Reverse-engineer how competitors do programmatic SEO. Detects URL pattern clusters (vs/, integrations/, for-{industry}/), estimates page count per pattern, analyzes template quality, infers which patterns actually drive traffic, and identifies gaps you can exploit. Outputs a competitive pSEO landscape report.
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Identify programmatic SEO page patterns worth building for your product — vs/ pages, integrations/, for-{industry}/, alternatives-to/, use-cases/ — and design the template structure, data model, and priority order. Outputs a complete pSEO blueprint with URL patterns, title templates, content frameworks, and data sources per variable.
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Render the logo-equation card ad (7s, 9:16) — partner icon + brand icon joined by a plus sign as an equation, a two-line "= outcome" headline, four numbered steps, and a CTA that hard-cuts in at 2s, on a static black card over timelapse b-roll, no voice. render_card.py draws the two card plates with measured geometry and hard guardrails (the user must confirm the integration is real, no partnership/endorsement/ranking words, no comment-bait CTA, no dashes); compose.py lays the card over the b-roll sped up to read as a timelapse, with an optional bed; measure_motion.py gates the b-roll (a real-time shot reads as a photo). Free, local.
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Manages Fabric deployment pipelines for ALM promotion across dev, test, and prod stages, including stage creation, workspace assignment, selective forward or backward deploys, operation polling, stage role assignments, and the pipeline and workspace permissions each action requires. For Git sync use git-integration-operations-cli.
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Comprehensive guide for developing WebGPU-enabled Three.js applications using TSL (Three.js Shading Language). Covers WebGPU renderer setup, TSL syntax and node materials, compute shaders, post-processing effects, and WGSL integration. Use this skill when working with Three.js WebGPU, TSL shaders, node materials, or GPU compute in Three.js.
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Configure Akka.NET with .NET Aspire for local development and production deployments. Covers actor system setup, clustering, persistence, Akka.Management integration, and Aspire orchestration patterns.
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Write unit and integration tests for Akka.NET actors using modern Akka.Hosting.TestKit patterns. Covers dependency injection, TestProbes, persistence testing, and actor interaction verification. Includes guidance on when to use traditional TestKit.
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Build reactive/event-driven C# with R3 (Cysharp's modern reimplementation of Reactive Extensions). Covers the Observable<T>/Observer<T> model, the OnErrorResume error contract, async dispatch with AwaitOperation, Task/IAsyncEnumerable integration, TimeProvider/FrameProvider scheduling, the concurrency contract, and how R3 differs from System.Reactive (Rx.NET).
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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.
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Orders and orients assembled contigs into chromosome-scale scaffolds from long-range linking data, inserting N-gap spacers (adds no sequence). Covers Hi-C/Omni-C scaffolding (YaHS, SALSA2, 3D-DNA/Juicer), Hi-C read-mapping prerequisites (map each end separately, no mate rescue, dedup, enzyme-aware), reading the contact map for misjoins/inversions/false-duplications, manual curation in Juicebox/PretextView (the VGP/DToL standard), reference-guided scaffolding (RagTag) and its karyotype-erasure hazard, genetic-map (ALLMAPS) and Bionano optical-map integration, chimera-breaking before scaffolding, gap-filling, and telomere/contig-vs-scaffold-N50 QC (tidk). Use when turning contigs into chromosomes with Hi-C, integrating a linkage map or optical map, choosing a scaffolder by available linking data, or judging whether a chromosome-scale assembly is trustworthy.
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Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.
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Build publication-quality figures with matplotlib using the object-oriented Figure/Axes API, constrained_layout, rcParams customization, TrueType (Type-42) font embedding for journal submission, and CVD-safe palettes. Covers seaborn integration, common chart types, axis formatting, and the small gotchas that distinguish reproducible matplotlib from notebook scratch. Use when producing publication figures in Python — RNA-seq scatter, single-cell embeddings, generic biological plotting.
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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).
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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.
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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.
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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Decode the marker fixture used by the DeepSeek Harness integration example.
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Use when accepting ANY real-world payment — Apple Pay, Wallet passes, Tap to Pay, Orders in Wallet. NOT in-app purchase / digital content (use axiom-integration). Covers entitlements, certs, signing, App Review payment rules.
日本語の概要は準備中です。原文の説明を表示しています。