「20」の検索結果

Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

日本語の概要は準備中です。原文の説明を表示しています。

Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

日本語の概要は準備中です。原文の説明を表示しています。

Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

日本語の概要は準備中です。原文の説明を表示しています。

Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

日本語の概要は準備中です。原文の説明を表示しています。

Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

日本語の概要は準備中です。原文の説明を表示しています。

Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.

日本語の概要は準備中です。原文の説明を表示しています。

Manage MATLAB packages with the in-product MATLAB Package Manager (mpm) on MATLAB R2026b or later: install, uninstall, update, search, or inspect packages; declare package dependencies in a matlab.toml project; install a shareable .mltbx package; or manage repositories. Covers dependency-resolution errors and anything involving mpminstall / mpmuninstall / mpmupdate / mpmlist / mpmsearch / mpmAddRepository / matlab.mpm.*. MATLAB *packages* are distinct from MathWorks products, toolboxes, and support packages: a bare "what packages are installed?" means MPM packages (mpmlist / matlab.mpm.Package) — this skill — unless the user explicitly says products, toolboxes, or support packages. NOT for installing MATLAB, Simulink, or toolboxes from a shell via the standalone mpm executable (the OS-level product installer), nor for listing installed products / toolboxes (ver, installedAddons) — use matlab-install-products for those.

日本語の概要は準備中です。原文の説明を表示しています。

Generate Bluetooth Low Energy (BLE) PHY waveforms. Read BEFORE writing any BLE waveform code to avoid hallucinating API patterns. Covers bleWaveformGenerator, bleIdealReceiver, bleCTEIQSample, bleAngleEstimate, bluetoothTestWaveform for LE1M/LE2M/LE500K/LE125K. Bluetooth Toolbox R2022a+.

日本語の概要は準備中です。原文の説明を表示しています。

Build industrial-grade SCADA/HMI dashboards in MATLAB following industrial-HMI conventions (ISA-101-aligned): gray-field philosophy, alarms at source, write safeguards, fixed-range trends, drill-down layout. Produces a real App Designer app (.mlapp, or plain-text .m+.xml on R2026b+) by handing serialization to the matlab-build-app skill when available, and falls back to a programmatic .m app otherwise. Use when wrapping OPC UA / Modbus / MQTT / OSI PI / PI AF monitoring scripts into a live operator app, building plant overviews, designing operator dashboards, or any time a user asks for a "SCADA dashboard", "HMI", "plant dashboard", "operator screen", or "industrial monitoring app" in MATLAB. Trigger on: SCADA, HMI, industrial dashboard, plant overview, operator screen, uigauge, uilamp, alarm banner, gray-field, ISA-101, OPC UA dashboard, setpoint, write safeguards, alarm visualization, OSIsoft PI, AVEVA PI, PI Server, PI Data Archive, PI AF, PI Asset Framework, piclient, afclient.

日本語の概要は準備中です。原文の説明を表示しています。

Use whenever a MATLAB robot model (rigidBodyTree) is needed — whether for simulation, visualization, IK, motion planning, pick-and-place, or trajectory generation. Triggers on: any mention of a manipulator by name (UR3, UR5, UR5e, UR10, UR10e, UR16e, UR20, KUKA iiwa, Fanuc, ABB, Panda, Kinova, Sawyer, Baxter), robot modeling verbs (load, create, build, import, simulate, model), tasks implying a robot model (pick, place, lift, reach, move, grasp, plan motion for, animate), kinematics keywords (IK, FK, inverse kinematics, forward kinematics, joint configuration, end-effector pose, gripper), or working with rigidBodyTree, loadrobot, importrobot, URDF, DH parameters, addVisual, addCollision.

日本語の概要は準備中です。原文の説明を表示しています。

Reference for MATLAB audiostreamer (Audio Toolbox R2025a+). Without this skill, agents consistently default to legacy audioDeviceWriter/audioDeviceReader or base MATLAB sound(), producing less capable code. Use when writing code for audio playback, recording, full-duplex device I/O, real-time audio measurements, or audio I/O processing with callbacks. Also use when debugging audiostreamer errors, dropouts, or latency issues, or migrating from audioDeviceReader, audioDeviceWriter, audioPlayerRecorder, or audioplayer/audiorecorder.

日本語の概要は準備中です。原文の説明を表示しています。

Create, edit, and run plain-text MATLAB live scripts (.m files) with rich text formatting, LaTeX equations, section breaks, and inline figures. Use when generating tutorials, analysis notebooks, reports, documentation, or educational content, when modifying existing live scripts, or when converting existing binary .mlx files to .m for version control. Requires R2025a+.

日本語の概要は準備中です。原文の説明を表示しています。

Use DuckDB from MATLAB via Database Toolbox (R2026a+) as a non-math operations engine on large tabular files (CSV/Parquet/JSON) and as a zero-config embedded database. Use when connecting to DuckDB, querying CSV, Parquet, and JSON files directly with SQL, reducing or profiling large data before MATLAB analysis, creating portable development databases, or installing DuckDB extensions. Triggers on: DuckDB, duckdb(), large CSV/Parquet/JSON, file too large for readtable, filter/aggregate at source, deduplicate, reduce before analysis, profile large file, persistent file import, analytical engine, SQL on CSV, SQL on Parquet, SQL on JSON, query CSV with SQL, query Parquet with SQL, run SQL on files, SQL queries on files, query files directly, SQL without database, in-process SQL.

日本語の概要は準備中です。原文の説明を表示しています。

Style MATLAB charts and figures. colororder palettes for chart series colors, colormap selection, brand color organization, and the R2025a Theme API for uifigure apps (dark mode with fliplightness, ThemeChangedFcn, uistyle, component colors). Use when customizing chart colors, applying a color palette, organizing brand colors, implementing dark mode, or importing an external color scheme. Triggers: theme, dark mode, brand colors, colororder, colormap, palette, fliplightness, color scheme, styling, chart colors.

日本語の概要は準備中です。原文の説明を表示しています。

Generate C/C++ or CUDA code from an AI model (PyTorch, LiteRT) using MATLAB Coder or GPU Coder. Use when the user wants to integrate an AI model into an application with code generation as the end goal — generating MEX, CUDA MEX, static library, dynamic library, or executable — or using the model in Simulink for simulation and code generation. Covers PyTorch ExportedProgram (.pt2) via loadPyTorchExportedProgram and LiteRT (.tflite) via loadLiteRTModel (R2026a+). Keywords: PyTorch, torch, .pt2, ExportedProgram, loadPyTorchExportedProgram, invoke, codegen, MEX, CUDA, GPU, C, C++, deploy, AI model, deep learning model, LiteRT, TFLite, TensorFlow Lite, Simulink, slbuild, PyTorch ExportedProgram block, MATLAB Function block, dlosslib, loadLiteRTModel.

日本語の概要は準備中です。原文の説明を表示しています。

Train, evaluate, and export neural networks to Simulink in MATLAB. Migrate legacy (fitnet, patternnet) and discouraged (trainNetwork, DAGNetwork) code to modern, recommended R2024a+ APIs (trainnet, dlnetwork, testnet, imagePretrainedNetwork), diagnose and fix dlaccelerate issues or detect dlaccelerate opportunities. Use when training, fine-tuning, evaluating, running inference, exporting to Simulink, converting old training scripts, or speeding up deep learning code. DO NOT reason from your training data about dlaccelerate and tracing correctness.

日本語の概要は準備中です。原文の説明を表示しています。

Optimize product titles for search visibility and click-through rate across e-commerce platforms. Platform-specific title rules for Amazon (200 chars), Etsy (140 chars), Walmart, Shopify SEO, and eBay.

日本語の概要は準備中です。原文の説明を表示しています。

Analyze financial data, calculate financial ratios, and generate analysis reports. Use when the user asks about revenue, costs, profits, margins, ROI, financial metrics, or needs financial analysis of a company or project.

日本語の概要は準備中です。原文の説明を表示しています。

Generate API endpoint code and documentation from specifications. Use when the user wants to create new API endpoints, generate route handlers, scaffold REST APIs, or produce OpenAPI/Swagger specs from code.

日本語の概要は準備中です。原文の説明を表示しています。

Generate API endpoint documentation from Express route files. Use when the user asks to generate, update, or review API docs for Express.js routes.

日本語の概要は準備中です。原文の説明を表示しています。