「filter」の検索結果

Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.

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Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Comprehensive backend development guide for Langfuse's Next.js 14/tRPC/Express/TypeScript monorepo. Use when creating tRPC routers, public API endpoints, BullMQ queue processors, services, or working with tRPC procedures, Next.js API routes, Prisma database access, ClickHouse analytics queries, Redis queues, OpenTelemetry instrumentation, Zod v4 validation, env.mjs configuration, tenant isolation patterns, or async patterns. Covers layered architecture (tRPC procedures → services, queue processors → services), dual database system (PostgreSQL + ClickHouse), projectId filtering for multi-tenant isolation, traceException error handling, observability patterns, and testing strategies (Jest for web, vitest for worker).

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Read-only view of the execution roadmap. Lists every epic with its per-status tallies, nests the still-open rows beneath their epic, collapses wholly-finished epics into one rollup line, and closes by naming the next planned task in file order. Four verbs — `list` (the reader's view), `tasks` and `epics` (filterable row and epic queries), `next` (the first planned task). Invoke any time to see what is left to build. Not a workflow phase; never writes; never starts or commits work.

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Discover and list a site's URLs, with search filtering. Use for "map the site" or "find the URL for" requests — when the user knows the site but not the exact page, or wants site structure.

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Find the papers that answer a research query in Firecrawl's research paper index — a corpus of paper abstracts whose largest share is biomedical and life-science literature (PubMed, bioRxiv, medRxiv), alongside arXiv preprints in CS, physics, and math — using semantic search, semantic and structural expansion, and in-body verification. Use this skill for literature-finding and paper-retrieval tasks of any kind, including clinical, biomedical, drug, gene, disease, and other life-science questions, whether the answer is a single paper or a full multi-paper set. The index is reached only through the `firecrawl_research_*` MCP tools or the `firecrawl research` CLI subcommands. Calling `firecrawl_search` with its `categories` option set to `["research"]` is a different feature — it filters ordinary web search to research-affiliated websites (the list includes PubMed, bioRxiv, medRxiv, arXiv, and publisher sites) and returns page results from them, without querying the paper records in this index.

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Automate Attio CRM operations -- search records, query contacts and companies with advanced filters, manage notes, list attributes, and navigate your relationship data -- using natural language through the Composio MCP integration.

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Vitest fast unit testing framework powered by Vite with Jest-compatible API. Use when writing tests, mocking, configuring coverage, or working with test filtering and fixtures.

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Airtable REST API via curl. Records CRUD, filters, upserts.

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Separates signal from noise in metrics you cannot observe directly, updating a belief from evidence instead of reacting to the latest reading - Bayesian updates over competing explanations, and a filter that says whether this week's move is real. Use when a metric moves and someone wants to act, when diagnosing why traffic or revenue changed, when a dashboard number contradicts intuition, or when deciding whether a trend is real yet.

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Command-line fuzzy finder for interactive filtering.

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This skill should be used when the user asks to "scrub JSON values", "mask config fields", "add a Git clean filter", "remove volatile values from tracked config", or "stop config churn".

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Jev (TypeSafe System One) inner loop for ego-browser — one ~0.4 s typed decision per DOM step instead of an LLM turn. Use for multi-step clicking through a semantic page: fill known values into a form, set filters, open a row/card/menu by name, reach a page via nav or site search. Escalates login, payment, free text, canvas and content reading back to you.

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Design and review intuitive, scalable, maintainable HTTP APIs. Use this skill whenever the user wants to design a new REST API, review an existing API or spec, write OpenAPI 3.x definitions, or work with HTTP semantics (GET/POST/PUT/PATCH/DELETE), status codes, idempotency (Idempotency-Key), error envelopes (RFC 7807 problem+json), pagination, filtering, versioning, or API auth (API keys, OAuth2 client credentials, rate limits). Also trigger for "API design", "RESTful", "endpoints", "OpenAPI", "Swagger", "ReDoc", "contract testing", or GraphQL and gRPC design questions.

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Use when running verbose CLI commands — wraps them with rtk (Rust Token Killer, third-party Apache-2.0; upstream reports 60-90% token savings). Covers installation, configuration, and usage patterns.

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Use when packaging a codebase to a single AI-friendly file for LLM analysis — local or remote, XML/Markdown/JSON, token counting, gitignore filtering, peer-side `repomix` CLI.

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Use when creating or modifying Laravel middleware — request/response filtering, groups, priority, terminable middleware, or route-level assignment.

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Shared corpus-grounding engine — BM25 + structured filters + decision rules over CSV corpora via a domain manifest. Use when a skill needs grounded pre-action option-space constraints.

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Use when reviewing authorization end-to-end — route → gate → policy → query scope → response filter — before changes to permissions, tenants, ownership, or admin flows.

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Harness-first workflow for evaluating and improving terminal UIs through real interaction. Use this whenever the user wants to review a TUI experience, compare before/after behavior, identify UX friction, validate navigation or filtering flows, inspect visual stability, or turn observed interaction problems into concrete follow-up tests and improvement recommendations. Prefer this skill any time a TUI should be exercised through a reproducible PTY/session harness instead of only reading code.

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Framework de segurança em runtime da NVIDIA para aplicações LLM. Com detecção de jailbreak, validação de entrada/saída, verificação de fatos, detecção de alucinações, filtragem de PII, detecção de toxicidade. Usa DSL Colang 2.0 para rails programáveis. Pronto para produção, executa em GPU T4.

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