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Save important context to persistent memory for future sessions. PROACTIVELY USE THIS when you detect: - Decisions: "let's go with", "decided to", "chose", "went with" - Learnings: "I learned", "turns out", "TIL", "realized", "discovered" - Errors resolved: "fixed", "the problem was", "solution was" - Client info: names, emails, phone numbers, addresses, invoice amounts - Preferences: "I prefer", "I like", "don't like", "always use" - References: API keys locations, file paths, URLs, credentials - Patterns: "pattern", "convention", "always do", "standard approach" - Important commands run worth remembering Do NOT ask permission - just capture silently when these patterns appear.

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Generate and save a session summary before ending conversation. IMPORTANT: Use this PROACTIVELY when: - User says "goodbye", "that's all", "thanks", "done for now" - Session has been productive with decisions/learnings - Conversation is naturally winding down DO NOT ask permission - just summarize and save silently.

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Choose what kind of knowledge to transfer between teacher and student models: response, feature, or relational, and decide among offline, online, self, or cross-modal distillation schemes. Best for distillation strategy selection, capacity-gap diagnosis, and transfer planning. Activate on "knowledge distillation", "teacher-student", "soft labels", "feature distillation", "online distillation", or "cross-modal transfer". NOT for generic compression checklists or unrelated training work.

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Use for affordances, hierarchical control, nullspace composition, and information-seeking action selection in embodied agents. NOT for pure symbolic planning, generic RL tuning, or domains without sensorimotor grounding.

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Learns from DAG execution history to improve future performance. Identifies successful patterns, detects anti-patterns, and provides recommendations. Activate on 'learn patterns', 'execution patterns', 'what worked', 'optimize based on history', 'pattern analysis'. NOT for failure analysis (use dag-failure-analyzer) or performance profiling (use dag-performance-profiler).

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Use for insight, reframing, contradiction, impasse, and anomaly-driven problem solving when execution effort no longer helps. NOT for routine optimization, error correction, or well-specified tasks with known solution paths.

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Introduce people to AI, agentic AI, and AI skills with appropriate pedagogy for any audience. Covers LLM analogies, progressive complexity paths, aha-moment demos, audience-tailored explanations, workshop design, and overcoming emotional barriers to AI adoption. Activate on 'explain AI', 'introduce AI', 'AI workshop', 'AI demo', 'teach AI', 'AI literacy', 'onboard to AI', 'AI evangelism', 'explain agentic', 'explain skills to', 'AI training session', 'AI onboarding'. NOT for teaching ML engineering (use ai-engineer), not for building AI features (use ai-engineer), not for prompt engineering (use prompt-engineer), not for building training data pipelines.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Detects m6A modifications from Oxford Nanopore direct-RNA-seq (DRS) signal using m6Anet (multiple-instance-learning over DRACH 5-mer signal). Covers the upstream pipeline (Dorado/Guppy basecalling -> minimap2 map-ont -> nanopolish eventalign -> m6anet dataprep -> m6anet inference), per-site vs per-read probability including the mod_ratio stoichiometry column, the DRACH-only constraint, minimum-coverage thresholds (20-50 reads/site), multi-condition comparison via xPore/Nanocompore/ELIGOS, Dorado native modification calling (RNA004, 2024+), and the cDNA-vs-DRS distinction (cDNA Nanopore CANNOT detect modifications). Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting probability_modified vs mod_ratio vs per-read probabilities, deciding between m6Anet (known DRACH sites) and Dorado/Remora (genome-wide screening), pinning RNA002 vs RNA004 chemistry and basecaller versions, or troubleshooting eventalign/dataprep failures.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

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Implement persistent memory patterns for AI agents using AgentDB. Includes session memory, long-term storage, pattern learning, and context management. Use when building stateful agents, chat systems, or intelligent assistants.

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Azure Machine Learning SDK v2 for Python. Use for ML workspaces, jobs, models, datasets, compute, and pipelines.

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AI-powered E2E web testing — eyes and hands for AI coding tools. Declarative YAML scenarios, Playwright execution, visual matching (OpenCV + OCR), platform auto-detection (Flutter/React/Vue), learning DB. Install: npx skills add ksgisang/awt-skill --skill awt -g

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AI and machine learning workflow covering LLM application development, RAG implementation, agent architecture, ML pipelines, and AI-powered features.

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End-of-week reflection report. Mines your Claude Code transcripts from the last 7 days to produce a self-contained HTML file with (1) the topics/areas you explored, (2) distilled key learnings with live-searched further-reading links, and (3) a token/command/skill/ctx-stack usage summary. Use when the user says "week in review", "weekly review", "what did I learn this week", "my week", or runs /week-in-review.

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Guide for creating and managing slash commands in Claude Code. Use when (1) creating new slash commands, (2) learning command syntax and features, (3) deciding between commands vs skills, (4) implementing advanced command features (arguments, hooks, bash execution), or (5) organizing and managing command libraries.

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Guide for defining and using Claude subagents effectively. Use when (1) creating new subagent types, (2) learning how to delegate work to specialized subagents, (3) improving subagent delegation prompts, (4) understanding subagent orchestration patterns, or (5) debugging ineffective subagent usage.

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复盘 v3（Workbench 门禁型）：启动本地 Workbench，用户在独立会话页确认想学的知识点和深度，按选择调研产出复盘文档； 同时落 2-3 条账本条目（记录/复盘/learnings.jsonl）供 bugfix/eng 开工回放与复发检测。 触发方式：用户说"总结知识"、"学习总结"、"复盘"、"可视化复盘"、"/forge-fupan"。

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Discover and analyze trending GitHub repositories from TrendShift and other sources — evaluate usefulness, extract learnings, and identify valuable skills/tools

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Turns past decisions into calibrated judgment - scoring old predictions against what happened, assigning credit for delayed results, and separating a bad decision from a good decision that lost. Use during a retrospective, postmortem, quarterly or monthly review, when reviewing decisions taken 30+ days ago, when attributing a result to a cause, or when someone claims to have called something.

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Mark a rolling-wave slice done on explicit user authority, regardless of its current lifecycle status or missing implementation, finalization, review, verification, or child-project state. Use when the user says a slice is done, complete, finished, accepted, or should be marked done; capture available material learnings, update project state, and output roadmap progress without requiring earlier workflow steps.

日本語の概要は準備中です。原文の説明を表示しています。