「search skill」の検索結果

Assists researchers with Institutional Review Board (IRB) application tasks, including drafting informed consent documents, reviewing research protocols for compliance, generating application forms, and preparing submission checklists. Use when the user mentions IRB, Instituti...

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Use when interpreting scientific graphs and charts, explaining data visualizations for research presentations, writing figure captions for publications, or analyzing trends in clinical research data. Converts complex visual data into clear, accurate explanations for academic papers, clinical reports, and public presentations.

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Structures and writes discussion sections for academic papers and research reports. Use when writing a discussion section, interpreting research results, connecting findings to existing literature, addressing study limitations, synthesizing conclusions, or drafting any part of...

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Builds clear, executable, and auditable inclusion and exclusion criteria for biomedical and clinical research protocols. Always use this skill when a user needs to translate a target population into operational screening rules tied to chart fields, time windows, tests, procedures, prior therapies, exclusions, and reviewable edge cases. Focus on protocol-stage precision, ambiguity reduction, auditability, and screening reproducibility rather than generic study design advice.

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Generates complete conventional single-gene oncology research designs from a user-provided cancer context, target gene, and validation direction. Use when a study centers on a fixed candidate gene and needs expression, prognosis, clinicopathologic association, functional interpretation, immune context, genomic or epigenetic context, optional drug-response hypotheses, and orthogonal validation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Refines broad, vague, or aspirational biomedical research objectives into clear, bounded, measurable, executable, and downstream-ready study objective statements. Always use this skill when a user has a general aim such as “explore a mechanism,” “study prognosis,” “investigate biomarkers,” or “look at treatment response,” but the objective is still too broad, non-operational, or too ambiguous to support protocol framing, design selection, analysis planning, or hypothesis design. Never assume that polished wording alone means the objective is actionable. Focus first on objective type, missing operational elements, scope discipline, and downstream-ready formulation.

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Designs studies for predicting treatment response or resistance in biomedical and clinical research. Always use this skill when the user needs a treatment-response or resistance prediction study blueprint rather than a prognostic biomarker protocol, diagnostic test design, causal treatment-effect estimation, or a completed manuscript. Focus on responder definition, treatment context, baseline comparability, feature integration strategy, model development logic, validation architecture, and interpretation boundaries. Do not invent response rates, cohort size, assay readiness, regimen uniformity, literature support, or validation access.

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Designs complete research plans that integrate clinical variables with multi-omics data from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a study that combines clinical variables with transcriptomics, proteomics, metabolomics, epigenomics, or related omics layers for mechanism interpretation, biomarker development, risk stratification, treatment-response analysis, or translational use. It should define the clinical use case, alignment across data layers, feature-reduction and fusion logic, modeling route, mechanism-interpretation layer, validation ladder, and four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, platform coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete conventional non-oncology diagnostic machine-learning research designs from a user-provided disease context, optional mechanism theme, and validation direction. Use when a study centers on disease-vs-control transcriptome comparison, optional mechanism-gene restriction, feature shrinkage, diagnostic model construction, ROC / calibration / DCA evaluation, interpretation layers, and orthogonal validation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Generates complete phenotype-scoring bioinformatics research designs for any disease context and any user-defined phenotype, pathway, process, signature, or molecular program. Use when a study centers on gene-set or feature-set definition, intersection with DEGs or candidate features, phenotype scoring, feature selection, diagnostic or stratification assessment, immune or cellular-resolution interpretation, network analysis, and optional orthogonal validation. Covers five study patterns (signature discovery, phenotype scoring, feature selection, immune/cellular interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete process-related diagnostic biomarker bioinformatics research designs from a user-provided disease context, gene-family or pathway theme, and validation direction. Use when a study centers on process-related genes, DEG and WGCNA integration, machine-learning feature selection, nomogram-based diagnostic modeling, immune infiltration, regulatory-network analysis, and optional external or experimental validation. Covers five study patterns (process-DEG discovery, co-expression-module integration, machine-learning biomarker selection, diagnostic model/nomogram workflow, immune-regulatory interpretation and validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

日本語の概要は準備中です。原文の説明を表示しています。

Designs discovery, modeling, and validation workflows for prognostic biomarkers in biomedical and clinical research. Always use this skill when the user needs a prognostic biomarker study blueprint rather than a diagnostic test protocol, predictive biomarker design, treatment recommendation, or a completed manuscript. Focus on endpoint family, follow-up horizon, time scale, candidate marker strategy, model-building logic, risk stratification framework, and internal/external validation requirements. Do not invent cohort size, event rate, assay readiness, literature support, or validation access.

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Use when determining author order on research manuscripts, assigning CRediT contributor roles for transparency, documenting individual contributions to collaborative projects, or resolving authorship disputes in multi-institutional research. Generates fair and transparent auth...

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete conventional non-oncology bioinformatics research designs from a user-provided disease context, process-related gene family or biological theme, and validation direction. Use when a study centers on multi-dataset bulk transcriptome integration, DEG analysis, process-gene intersection, enrichment analysis, GSEA, PPI hub-gene prioritization, TF/miRNA regulatory networks, ROC-based biomarker evaluation, and immune infiltration analysis. Covers five study patterns (process-DEG discovery, enrichment/GSEA interpretation, hub-gene prioritization, regulatory-network and immune interpretation, multi-layer public validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

日本語の概要は準備中です。原文の説明を表示しています。

Designs primary, secondary, and exploratory endpoints for biomedical and clinical research protocols. Always use this skill when a user needs to translate study aims into operational endpoint definitions with event rules, assessment timing, composite logic, interpretability, and protocol-stage auditability. Focus on endpoint precision, feasibility, clinical meaning, ambiguity reduction, and implementation readiness rather than generic study design advice.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Use when a study links two clinically related diseases through shared DEGs, enrichment, PPI hub genes, machine-learning feature selection, public diagnostic validation, gene-regulatory networks, immune infiltration, and optional downstream follow-up. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, machine-learning biomarker selection, immune/regulatory interpretation, multi-layer validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

日本語の概要は準備中です。原文の説明を表示しています。

Designs retrospective or prospective clinical cohort study protocols for biomedical and clinical research. Always use this skill when the user needs a cohort-based study plan rather than a general study idea, evidence summary, or mechanistic experiment design. Focus on cohort appropriateness, enrollment logic, baseline time-zero definition, follow-up structure, endpoint definition, variable collection, confounding control, and a coherent primary statistical analysis line. Do not invent data availability, follow-up completeness, outcome ascertainment quality, sample size adequacy, or causal interpretability.

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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.

日本語の概要は準備中です。原文の説明を表示しています。

Compares multiple study-route options for the same biomedical research question and recommends one primary plan, while explicitly explaining why alternative routes are secondary, premature, weaker, or dependency-heavy. Always use this skill when the user already has a reasonably defined question but is unsure which main study route should anchor the project. Focus on plan comparison, route selection, dependency awareness, and primary-plan justification rather than full protocol drafting.

日本語の概要は準備中です。原文の説明を表示しています。

Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.

日本語の概要は準備中です。原文の説明を表示しています。

Designs a realistic, execution-aware biomedical study version under explicit constraints of samples, time, budget, data access, lab capacity, team skill, and validation resources. Always use this skill when the user has a real study idea, a candidate route, or a partially framed project but cannot assume ideal conditions. If critical feasibility inputs are missing, first clarify what resources are currently available, what resources may be obtainable, and what resources are realistically unavailable. Do not invent access, capabilities, collaborations, or validation resources. Focus first on feasibility-constrained study framing, route narrowing, dependency control, and minimum viable study design.

日本語の概要は準備中です。原文の説明を表示しています。

Detects methodological gaps across study design, analysis, validation, bias control, reproducibility, and implementation readiness within a biomedical research area. Use this skill when a user wants to identify what current studies are still methodologically missing, which weaknesses are most consequential, and what upgrade path would produce a stronger next-step study. Always separate design gaps, analysis gaps, validation gaps, and reproducibility gaps. Never treat technical complexity as methodological rigor.

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Designs primary aims, secondary aims, and testable hypotheses from broad biomedical research ideas. Use this skill when a user needs to convert a loose study idea into a tighter protocol-framing structure with clear aim hierarchy, hypothesis discipline, and separation between hypothesis-driven and exploratory components. Always keep aims answerable, non-overlapping, and aligned to the intended evidence type and study scope.

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Detects overlooked, underrepresented, weakly resolved, or poorly validated populations and subgroups within a biomedical research area so users can identify more precise and meaningful study populations. Always use this skill when the real question is not just what is under-studied, but which populations, strata, or subgroups are missing, thinly represented, superficially analyzed, pooled without resolution, or insufficiently validated in the current evidence base. Focus on meaningful subgroup gaps rather than generic calls for diversity.

日本語の概要は準備中です。原文の説明を表示しています。