1.3万 件 ・ 関連度順
概要と使いどころ
Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.
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Use when users need bioinformatics analysis on the NCPGR cluster, especially when converting analysis requests into local software choices, resource plans, and LSF job scripts.
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Trim multiple sequence alignments using ClipKIT, trimAl, BMGE, Divvier, or HMMcleaner with mode selection guidance per downstream goal. Use when removing unreliable columns or contaminating residues before phylogenetic inference, HMM building, or selection analysis.
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Generate pileup data for variant calling using samtools mpileup and pysam. Use when preparing data for variant calling, analyzing per-position read data, or calculating allele frequencies.
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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
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Creates sashimi-style plots showing RNA-seq read coverage and splice junction counts using ggsashimi (general-purpose, condition-grouped overlays), rmats2sashimiplot (rMATS-output-aware), MAJIQ-VOILA (LSV posteriors interactive HTML), leafviz (leafcutter clusters Shiny), Jutils (tool-agnostic heatmaps and sashimi for rMATS/leafcutter/SUPPA2/MAJIQ output), or pyGenomeTracks (multi-track publication figures). Tool choice depends on the upstream differential-splicing tool's output format and the publication vs interactive use case. Use when visualizing specific splicing events, validating differential splicing calls, or producing publication-quality figures.
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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.
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Classify a request into type, risk, and the destination CodeConductor command.
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Design, implement, and review web interface layout, component states, feedback, and motion within the current CodeConductor workflow. Use for concrete web UI work or requested UI audits, not backend-only tasks or native mobile apps.
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Design and coordinate multi-agent systems where specialized agents work together to solve complex problems. Covers agent communication, task delegation, workflow orchestration, and result aggregation. Use when building coordinated agent teams, complex workflows, or systems requiring specialized expertise across domains.
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Map owned assets, attack surface, and inventory for systems the requester is authorized to assess. Use for asset discovery, service catalogs, and exposure reviews — never unauthorized scanning.
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Refactor Spring Boot and Java code to improve maintainability, readability, and adherence to enterprise best practices. This skill transforms messy Spring Boot applications into clean, well-structured solutions following SOLID principles and Spring Boot 3.x conventions. It addresses fat controllers, improper transaction boundaries, field injection anti-patterns, and scattered configuration. Leverages Java 21+ features including record patterns, pattern matching for switch, virtual threads, and sequenced collections.
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Debug Spring Boot issues systematically. Use when encountering bean errors like NoSuchBeanDefinitionException, circular dependency issues, application startup failures, JPA/Hibernate problems including LazyInitializationException and N+1 queries, security misconfigurations causing 403 Forbidden errors, property binding failures, CSRF token issues, or any Spring Boot application requiring diagnosis with Actuator endpoints and JVM debugging.
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Design, implement, review, and audit Android Jetpack Compose UI/UX for phone interfaces. Use when a request concerns concrete Compose layout, components, interaction, accessibility, or visual behavior. Do not activate for framework or dependency presence alone; non-UI Android work is excluded.
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Ultra-compressed communication mode. Cuts token usage ~75% by speaking like caveman while keeping full technical accuracy. Supports intensity levels: lite, full (default), ultra, wenyan-lite, wenyan-full, wenyan-ultra. Use when user says "caveman mode", "talk like caveman", "use caveman", "less tokens", "be brief", or invokes /caveman. Also auto-triggers when token efficiency is requested.
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Run the API contract workflow for request/response shape changes, compatibility constraints, contract tests, documentation, and review.
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Guides agents through Red-Green-Refactor with runner-captured evidence. Use when running /cc-tdd-cycle, writing tests before implementation, or Global TDD required is yes.
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Testing patterns for multi-tenant Django POS projects using pytest-django, RequestFactory, and mocks. No factories, no complex conftest. Trigger: When writing or reviewing tests in any apps/ directory.
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Run the database migration workflow for schema/data changes, operational sequencing, tests, and review.
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Create distinctive, production-grade frontend interfaces with high design quality. Generates creative, polished code that avoids generic AI aesthetics. Use when the user asks to build web components, pages, artifacts, posters, or applications, or when any design skill requires project context.
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Routes general Convex requests to the right project skill. Use when the user asks which Convex skill to use or gives an underspecified Convex app task.
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Use this skill when the user's prompt requires (1) researching a topic across multiple sources, comparing options or alternatives, analyzing trends or history, understanding markets or industries, or reviewing literature or studies and (2) synthesizing that research into a comprehensive, narrative report. If you're planning to search the web or internal knowledge bases, consider using this skill. This skill coordinates research subagents, so use it only when you have a tool for spawning subagents (the Agent or Task tool); otherwise, research the question directly.
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Render the user's morning brief as a styled HTML artifact, or set it up as a recurring weekday task. Use only when the user explicitly asks to run, see, or set up their morning brief, or if they invoke /morning by name. A question about their day, schedule, or calendar is not by itself a request for the brief; answer it directly instead.
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Orientación legal y guía de procesos contractuales para el equipo de Vambe (Chile/MX). Usar SIEMPRE ante preguntas legales o de contratos: 'quiero enviar un contrato', 'cómo mando el NDA', 'el cliente quiere cambios', 'cliente M vs L', '¿me pueden demandar?', 'el cliente no paga', 'cómo finiquito a un empleado', 'protección de datos', 'qué le digo al cliente sobre sus datos', 'nos acusan de incumplimiento', 'me llegó carta de abogados', 'quién puede firmar', 'quién es dueño del código', o cualquier consulta sobre contratos, NDAs, reclamos, laboral, RRHH, PI o cumplimiento normativo.
日本語の概要は準備中です。原文の説明を表示しています。