「calibration」の検索結果

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Predicts ADMET properties using ADMETlab 3.0 (119 platform features, including 77 prediction models with modeled-endpoint uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

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Analyze AMS waveform data using Mixed-Signal Blockset utilities: phase noise measurement, clock jitter, anti-aliased resampling, timing measurements, lock time, INL/DNL, ADC/DAC calibration, HSpice import. Use when analyzing time-domain voltage from PLL/VCO/clock simulations, measuring phase noise from variable-step solver output, computing jitter, or resampling non-uniform data.

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Work with hyperspectral and multispectral images in MATLAB. Covers reading/writing (ENVI, NITF, TIFF, Sentinel-2, Landsat, ASTER), ECOSTRESS spectral libraries, processing (calibration, atmospheric correction, denoising, sharpening, dimensionality reduction, endmember extraction, unmixing, target/anomaly detection, spectral indices, segmentation), labeling (Spectral Image Labeler app, ground truth objects, automation algorithms), and deep learning (pixel classification CNNs, unmixing autoencoders, transfer learning). Use when reading, writing, processing, analyzing, classifying, labeling, or applying deep learning to hyperspectral or multispectral images.

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Polish mathematical modeling paper drafts for grammar, clarity, formula consistency, hedging calibration, overclaim detection, and contest formatting compliance. Use after paper-section-writer has drafted sections.

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Design calibrated interview loops, competency-based question banks, and hiring calibration. Use when designing interview processes, creating hiring pipelines, generating scoring rubrics, analyzing interviewer bias, or building question banks.

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Use when the user has a judge/grader and human-labeled data, and wants to measure how well the judge agrees with humans, detect systematic biases, determine whether automatic evaluation can replace human review, or build a human-reduction roadmap. Also use when the user mentions calibration, TPR/TNR, judge validation, inter-rater agreement, Cohen's kappa, bias detection, or "is my automatic evaluation trustworthy." Merges the calibrate and align functions into one skill.

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Systematic contract negotiation strategies for technology services agreements with German/EU law specificity. Provides three-position framework (provider-favorable, balanced, client-favorable), deal-size calibration (€100K to €10M+), five-tier objection handling with regulatory leverage (GDPR, DORA, NIS2, BGB), concession packaging, and position matrices for liability, IP, payment, SLA, data protection, and termination. Use when: (1) Developing negotiation strategies for SaaS, cloud, or managed services agreements, (2) Preparing position papers and fallback positions, (3) Responding to counterparty objections, (4) Structuring concession packages that protect core economics, (5) Calibrating tactics to deal size and leverage, or (6) Applying German contract law constraints (BGB §§ 305-310 AGB, § 309 Nr. 7 liability limits, § 288 statutory interest).

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Generate a spreadsheet of test entries — newly designated names from OFAC, OFSI, and EU sanctions lists plus deliberate variations of those names — to validate that a sanctions screening system catches fresh designations and is tuned to the right fuzziness threshold. Use this whenever the user asks for sanctions list update test data, screening regression test data, screening QA, fuzzy match calibration, or wants to verify their screening lists are current. Trigger even if the user doesn't say 'screening' explicitly — phrases like 'test my sanctions list', 'check our SDN coverage', 'is my list up to date', or 'build me a regression set from the latest designations' should also invoke this skill.

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Review the week using accumulated session evidence — retrieval rates, hint depths, calibration accuracy, transfer and unassisted results. The learner identifies patterns and sets a strategy goal. Use weekly or after a multi-session period.

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Design metacognitive checkpoints that prevent AI-assisted learning from bypassing genuine understanding. Use when students use AI tools and may overestimate their own comprehension.

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Use when auditing or recalibrating game balance: build a source-driven Monte Carlo balance lab (Rust + rayon) that extracts live game data, simulates human playstyles (AFK→pro), emits win-rate/economy verdicts with confidence intervals, and bruteforce-tunes parameters. Trigger on unfair levels, unreachable shops, farm exploits, interest-curve cliffs, post-content recalibration, or CI balance JSON diffs. Keywords: balance lab, Monte Carlo, win rate, difficulty curve, economy career, playstyle simulation, Resource extraction, GDScript parser, bruteforce tuning.

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This package implements a suite of methods to preprocess data from PTR-TOF-MS instruments (HDF5 format) and generates the 'sample by features' table of peak intensities in addition to the sample and feature metadata (as a single ExpressionSet object for subsequent statistical analysis). This package also permit usefull tools for cohorts management as analyzing data progressively, visualization tools and quality control. The steps include calibration, expiration detection, peak detection and qua

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Calibrate a reviewer persona with few-shot rubric examples so skepticism stays consistent and doesn't drift lenient over long runs.

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Monthly, on the last weekday, file work only, no browser at all. Folds the decision ledger, scores this Employee's own judgement against the metric files that measured it rather than against its own predictions, appends one outcome line per closed decision, retires a move proposed three times and never accepted, and rewrites the priorities where the evidence disagrees with them. It refuses to publish a calibration figure on too few closed decisions, changes nothing outside its own folder, proposes nothing to anybody, sends only where you released the channel, spends only where you released it, and never touches a credential.

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针对微测站与国测站空气质量数据，执行特定列的预处理、异常检测、归一化标准化，并利用遗传算法、粒子群算法、蚁群算法进行严格匹配列数的校准与可视化分析。

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Agent reputation scoring, performance tier system, trust calibration, and task affinity matching

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Produces human-sounding text that avoids detectable AI writing patterns. Activates on any writing task — tweets, emails, articles, bios, captions, reports, copy, messages, LinkedIn posts, cover letters, README files, or any content where the output must not read as AI-generated. Enforces banned vocabulary, structural variety, punctuation discipline, accuracy rules, and voice calibration. Use when the user says "write," "draft," "rewrite," "make this sound human," "anti-slop," "not AI," or any variation of wanting authentic-sounding output.

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Use with every WinDbg plugin investigation to apply evidence-first reasoning, confidence calibration, contrarian review, structured reporting, and deterministic validation. Not a bug-family-specific triage skill.

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Review mathematical modeling competition papers from a complete problem and paper, with an optional strict bzd-paper-format-checker audit, itemized problem-specific scoring, a bottom-up low-score safeguard, and CUMCM award calibration by problem type, division, region, school and advisor. Generate a Chinese HTML judge report.

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Expert guidance for ffuf web fuzzing during penetration testing, including authenticated fuzzing with raw requests, auto-calibration, and result analysis

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