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Compare ENCODE experiments across different biosamples, tissues, or cell lines to identify tissue-specific regulatory patterns. Use when the user wants cross-tissue comparison, cell-type comparison, tissue-specific elements, differential chromatin, biosample matching, disease vs normal comparison, developmental time course, constitutive vs variable regulation, or multi-tissue data availability mapping. Handles batch effect detection, biosample hierarchy, and comparison design.

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Verify that browser profiles are actually isolated from one another instead of assuming it - confirm each profile's timezone agrees with its own exit IP, that WebRTC exposes only the proxy, that canvas and WebGL hashes stay identical across relaunches of one profile, and that no two profiles share a persona, a cookie jar, or an address. Use when several of your own accounts or test identities run from one machine and the setup needs checking, when a profile tested clean but something still looks off, when choosing which detection suites to run (CreepJS, whoer, browserleaks WebRTC, pixelscan, liarjs), when auditing what a vendor runtime does with API and proxy credentials, or when asking which layers browser isolation cannot cover at all. Also for 'profile isolation check', 'fingerprint consistency test', 'timezone mismatch', 'WebRTC leak', 'canvas hash unstable', 'account association', 'temporary profile', '防关联', '多账号', '隔离自检'. The SDK is anti-detect-browser; MCP is browser-mcp-agent.

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Drafts U.S. regulatory client advisory summaries translating legal developments into actionable risk and compliance guidance. Use when a client needs a proactive memo, client alert, or legal-update brief for a new law, case, rulemaking, agency guidance, or pending reform. Trigger on requests for "client advisory," "regulatory update," "legal alert," "compliance briefing," "new law summary," or "quarterly advisory."

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Data structures and algorithms for AI agent episodic memory. Covers vector stores (HNSW, IVF, PQ), temporal indexing, knowledge graphs with triple stores, hierarchical summarization, forgetting curves, working/long-term/ procedural memory, and memory consolidation. Deep analysis of MemGPT/Letta, Zep/Graphiti, Mem0, and the Stanford generative agents memory architecture. Teaches the CS fundamentals behind how agents remember, retrieve, and forget. Activate on: "agent memory", "episodic memory", "vector search algorithm", "HNSW", "memory retrieval", "forgetting curve", "knowledge graph memory", "MemGPT", "Letta", "Zep", "Mem0", "memory consolidation", "temporal retrieval", "agent long-term memory", "memory layer". NOT for: conversation protocol design (use agent-conversation-protocols), agent infrastructure selection (use agentic-infrastructure-2026), building RAG pipelines (use ai-engineer).

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This skill recommends using biochemical tests to screen for hypercortisolism to detect recurrence in patients with ACTH-dependent Cushing's syndrome after surgical remission. It is triggered during postoperative follow-up when the HPA axis has recovered, annually, or sooner if clinical signs of hypercortisolism (e.g., weight gain, hypertension, glucose intolerance) or abnormal late-night salivary cortisol/UFC appear.

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This skill recommends glucocorticoid replacement and patient education for hypocortisolemic patients after surgical remission of Cushing's syndrome. Use when a postoperative Cushing's patient exhibits low cortisol (e.g., morning cortisol <5 µg/dL) or symptoms of adrenal insufficiency.

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This skill recommends that all patients with Cushing’s syndrome receive monitoring and adjunctive treatment for cortisol-dependent comorbidities including psychiatric disorders, diabetes, hypertension, hypokalemia, infections, dyslipidemia, osteoporosis, and poor physical fitness. Apply when managing any CS patient to address associated health issues; triggers include confirmed or suspected hypercortisolism, preoperative evaluation, postoperative follow‑up, or persistent hypercortisolism despite treatment.

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This skill recommends against initiating treatments aimed at normalizing cortisol or its action when only borderline biochemical abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis are present without specific signs of Cushing's syndrome. Use when encountering borderline urinary free cortisol, late-night salivary cortisol, or dexamethasone suppression test results without classic Cushingoid features; triggers include borderline UFC (1-2× ULN), equivocal late-night salivary cortisol, or nondiagnostic low-dose DST.

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In pregnant women with primary adrenal insufficiency (PAI), the guideline suggests using hydrocortisone over cortisone acetate, prednisolone, or prednisone for glucocorticoid replacement. It recommends against dexamethasone due to its lack of placental inactivation, which can expose the fetus to excess glucocorticoid exposure.

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Recommends against using a random cortisol level to diagnose adrenal insufficiency. Triggers when considering a random cortisol test for AI evaluation (e.g., "random cortisol measurement being considered for AI diagnosis").

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Accounts for estrogen-induced elevation of total serum cortisol via increased corticosteroid-binding globulin (CBG) when evaluating adrenal reserve or hydrocortisone replacement adequacy. Triggered when assessing glucocorticoid adequacy in patients receiving estrogen therapy (e.g., oral estrogen replacement) or interpreting cortisol levels in estrogen-exposed individuals.

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Reviews a proposal, business case, deck or plan in character as a Chief Information Security Officer archetype and returns a DRAFT review with a verdict, findings cited to specific passages, security and compliance risks and the five interrogation questions a real CISO would ask. Use when the user asks to "run a CISO review", "pressure-test the security of this plan", "what would our CISO say about this" or "check the privacy and third-party risk". Do not use for contract, liability or regulatory-interpretation reviews, use general-counsel-reviewer instead. Drafts for human review; never approves, authorises or signs off.

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Comprehensive toolkit for preparing ISO 13485 certification documentation for medical device Quality Management Systems. Use when users need help with ISO 13485 QMS documentation, including (1) conducting gap analysis of existing documentation, (2) creating Quality Manuals, (3) developing required procedures and work instructions, (4) preparing Medical Device Files, (5) understanding ISO 13485 requirements, or (6) identifying missing documentation for medical device certification. Also use when users mention medical device regulations, QMS certification, FDA QMSR, EU MDR, or need help with quality system documentation.

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Affiliate and sponsored content generator — create natural product review, comparison, and recommendation articles that comply with ステマ規制. Integrates compliance-checker for automatic legal safety. Supports review, comparison, and experience-based formats.

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Data structures and algorithms for AI agent episodic memory. Covers vector stores (HNSW, IVF, PQ), temporal indexing, knowledge graphs with triple stores, hierarchical summarization, forgetting curves, working/long-term/ procedural memory, and memory consolidation. Deep analysis of MemGPT/Letta, Zep/Graphiti, Mem0, and the Stanford generative agents memory architecture. Teaches the CS fundamentals behind how agents remember, retrieve, and forget. Activate on: "agent memory", "episodic memory", "vector search algorithm", "HNSW", "memory retrieval", "forgetting curve", "knowledge graph memory", "MemGPT", "Letta", "Zep", "Mem0", "memory consolidation", "temporal retrieval", "agent long-term memory", "memory layer". NOT for: conversation protocol design (use agent-conversation-protocols), agent infrastructure selection (use agentic-infrastructure-2026), building RAG pipelines (use ai-engineer).

日本語の概要は準備中です。原文の説明を表示しています。

OpenClawのリリース候補を人が試すために、隔離コピーなどの検証環境を準備し、テストの進行とフィードバック整理を支援します。公開前の報告確認も扱います。

• Gatewayの隔離コピーで検証したいとき
• 操作画面ごとに人がテストしたいとき
• 公開前に検証報告を確認したいとき

Handle confidential GitHub Security Advisory response for Paperclip. Use when coordinating advisory triage, private-fork fixes, CVE/publication steps, and immediate security releases.

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Detects and prevents code injection attacks targeting serverless functions (AWS Lambda, Azure Functions, Google Cloud Functions) through event source poisoning, malicious layer injection, runtime command execution, and IAM privilege escalation via function modification. The analyst combines static analysis of function code, CloudTrail event correlation, runtime behavior monitoring, and IAM policy auditing to identify injection vectors across the expanded serverless attack surface including API Gateway, S3, SQS, DynamoDB Streams, and CloudWatch event triggers. Activates for requests involving Lambda security assessment, serverless injection detection, function event poisoning analysis, or serverless privilege escalation investigation.

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Identify poisoned training data and backdoored ML models across the pipeline using IBM's Adversarial Robustness Toolbox (activation clustering, spectral signatures, trigger reconstruction), Cleanlab for label-quality issues, and supply-chain checks like weight-hash verification and safetensors enforcement. Use before training or deploying on third-party/user-contributed data or downloaded checkpoints, during ML supply-chain reviews, or when investigating model misbehavior tied to specific inputs (suspected backdoor trigger).

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Detect Layer 2 ARP poisoning/spoofing by deploying ARPWatch, Dynamic ARP Inspection (DAI), Wireshark packet analysis, and custom Python monitoring scripts that flag gratuitous ARP floods, IP-to-MAC mapping changes, and duplicate IP addresses. Use when investigating suspected man-in-the-middle interception or session hijacking on a local network segment, or when building layer-2 anomaly detection for a SOC.

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Executes containment strategies to stop active adversary operations and prevent lateral movement during a confirmed security breach. Implements short-term and long-term containment using network segmentation, endpoint isolation, credential revocation, and access control modifications. Activates for requests involving breach containment, lateral movement prevention, network isolation, active threat containment, or live incident response.

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Designs and implements VLAN-based (802.1Q) network segmentation on managed switches to isolate zones such as corporate, servers, DMZ, guest, and IoT, and to limit lateral movement paths. Use when segmenting an enterprise network into isolated security zones, meeting compliance mandates (PCI-DSS, HIPAA, SOC 2) for network isolation, or reducing blast radius from a security incident.

日本語の概要は準備中です。原文の説明を表示しています。