「mechanism」の検索結果

Generates complete Mendelian Randomization + single-cell transcriptomics (scRNA-seq) research designs from a user-provided direction. Always use this skill whenever a user wants to design, plan, or build a study combining MR and single-cell data — even if phrased as "help me write a paper on X", "design a bioinformatics study for Y", or "I want to study Z using MR and scRNA". Covers five study patterns (mechanism gene-set, key-cell, candidate-gene reverse validation, exposure-disease-cell triangulation, translational biomarker) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.

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Design evidence-discovery and validation workflows for drug repurposing studies by integrating disease mechanisms, drug-target logic, expression reversal, real-world evidence, and validation routes into a closed-loop study blueprint.

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Designs complete single-cell research plans from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a single-cell study — including disease-focused, mechanism-focused, biomarker-focused, translational, perturbation-inspired, or validation-aware projects. It should define the research question, choose the best-fit study pattern, recommend sample grouping logic, suggest reference datasets as examples only, specify the core analysis modules, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, sample metadata, accession numbers, cohort availability, cell-type labels, external validation resources, or literature references. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Finds translational opportunities that connect basic-research discoveries to clinically meaningful use cases such as diagnosis, stratification, prognosis, treatment response prediction, monitoring, or therapeutic development. Use this skill when a user wants to turn a mechanism finding, pathway signal, cellular phenotype, experimental observation, or omics discovery into a stronger translational research direction. Always separate mechanistic relevance from translational usability, and never present a basic finding as clinically actionable unless the evidence supports that level.

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Designs complete integrated research plans for bulk transcriptomics, proteomics, metabolomics, and related omics from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a bulk multi-omics or single-omics-plus-clinical study — including disease-focused, mechanism-focused, biomarker-focused, stratification-oriented, or translational projects. It should define the research question, choose the best-fit study pattern, recommend example datasets as reference candidates only, specify the core analysis modules and method choices, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, cohort availability, assay coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Designs cell-based and animal-based validation plans that translate computational, omics, biomarker, genetic, or clinical findings into experimentally testable validation routes. Always use this skill whenever a user wants to move from an in silico, statistical, or clinical association finding toward wet-lab validation using cell systems, organoid-like systems, xenograft or genetically relevant animal models. It should define the exact claim to test, separate mechanism-testing from association-support and translational-support goals, choose the best-fit model family, specify perturbation strategy, readouts, controls, sequencing of experiments, and four workload configurations (Lite / Standard / Advanced / Publication+) with one recommended primary plan. Never fabricate model availability, reagent availability, species relevance, assay feasibility, phenotype penetrance, expected effect sizes, validation success, or literature references.

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Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...

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Evidence-based medical knowledge and research mentor grounded in the Bian Que tradition. Covers clinical reasoning, diagnostic thinking (望闻问切), pharmacology, pathology, differential diagnosis, medical literature appraisal, and the philosophy of early intervention. Trigger whenever users ask about medicine, clinical science, drugs, disease mechanisms, diagnosis, lab interpretation, treatment comparison, or health sciences. Even without explicit research framing, trigger on any topic touching disease, therapeutics, or clinical decision-making. Part of the AIPOCH Medical Research Skill Hub.

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Composes a Discussion around key findings, mechanisms, clinical relevance, and limitations. Use when writing or improving a Discussion section for any biomedical manuscript — including interpreting results, connecting to prior literature, addressing unexpected findings, framing limitations, and writing the conclusion. Also triggers on "write my discussion", "help me discuss my findings", "how do I compare to prior studies", "write the limitations paragraph", or "draft a discussion for my paper".

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Draft and submit evidence-backed XQUIC GitHub bug issues in the repository's CONTRIBUTING and issue-template format. Use when preparing or opening an alibaba/xquic issue that must identify an exact RFC or draft mechanism, expected-versus-actual behavior, reproduction evidence, and optional verified source root cause; requires issue-check to return true before any GitHub submission.

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Verify whether a proposed XQUIC bug issue is real by checking the cited RFC or Internet-Draft mechanism against the repository's actual source behavior, tracing any root cause to current file and line evidence, and returning a fail-closed boolean gate. Use when validating an issue draft, investigating a claimed QUIC, HTTP/3, QPACK, or MoQT protocol violation, or before issue-submit may publish an issue.

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Use when evaluating crypto protocols through a Paradigm-style research lens: mechanism design, protocol fundamentals, L2/MEV/incentives, and research-driven crypto investing.

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Multi-protocol consensus for agent swarms supporting Raft leader election, Byzantine fault tolerance, Gossip state propagation, and CRDT conflict-free merging.

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Implement safety interlocks and protective mechanisms to prevent equipment damage and ensure safe control system operation.

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Implement paper-defined attention variants by extracting mechanism invariants, mapping tensor shapes, preserving module interfaces, validating numerical behavior, and integrating the custom attention into an existing transformer stack.

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Understand anti-reversing, obfuscation, and protection techniques encountered during software analysis. Use when analyzing protected binaries, bypassing anti-debugging for authorized analysis, or understanding software protection mechanisms.

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Invoke the locally installed Grok Build CLI from Codex and return Grok's response. Use whenever the user asks Codex to call, consult, run, or delegate a prompt to Grok or Grok Build, including Grok web/X searches and agentic Grok tasks. This Skill covers only the invocation mechanism, process monitoring, and response capture; it does not prescribe the task itself.

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传播心理解码。给定一段内容，用 5 个经典传播学理论解码它为什么能引起受众共鸣，分析受众情绪底层和有效立场，输出聊天室的讨论方向。 触发方式：/dbs-spread、「传播心理解码」、「为什么这个能火」、「受众想听什么」、「这个内容打中了什么情绪」 Transmission psychology decoder. Given a piece of content, analyze the psychological mechanism that makes it resonate, identify the emotional core and effective stance, and output direction for chatroom discussion. Trigger: /dbs-spread, "why does this resonate", "what emotion does this hit", "decode this content"

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Keep a change small and in the existing idiom - size the plan and weigh smaller alternatives before writing it, reuse the mechanism that already owns the behavior instead of adding a parallel one, and simplify the diff before handoff. Use when planning any change beyond a few lines, before readying a PR, or when reviewing agent-written code for bloat.

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Audit whether prior learnings actually fired, then install mechanisms for this run's recurrences. No finding without an install path and a firing test. Triggers: retrospective, reflect, what did we learn, patterns, post-mortem, why does this keep happening.

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Use when targeting Global Change Biology or deciding whether a biology/ecology manuscript fits this venue. Encodes the journal's fit, the global-change-driver framing and biological-evidence bar, scale and mechanism expectations, house style, official-submission re-check, and desk-reject heuristics.

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Use when targeting Food Chemistry or deciding whether a food-chemistry manuscript fits this venue. Encodes the journal's fit, the analytical-rigor and chemical-mechanism bar, method-validation expectations, house style, official-submission re-check, and desk-reject heuristics.

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Use when targeting Soil Biology & Biochemistry or deciding whether a soil-science manuscript fits this venue. Encodes the journal's fit, the soil-process-mechanism bar, evidence and data-reporting expectations, house style, official-submission re-check, and desk-reject heuristics.

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Use when the question is what makes the result tight or what the data identify for an American Economic Journal: Microeconomics (AEJ: Micro) manuscript — covering both (a) structural/empirical-IO and experimental identification and (b) for pure theory, which assumptions drive the result and how robust the mechanism is. Stress-tests credibility; it does not build the model (see aejmic-theory-model).

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