「nature」の検索結果

Use when targeting Nature Food or deciding whether a food-systems manuscript fits this venue. Encodes the journal's fit, the food-systems-significance and transdisciplinary bar, evidence and reproducibility expectations, house style, official-submission re-check, and desk-reject heuristics.

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Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Document control for medical device QMS, covering numbering, version control, change management, and 21 CFR Part 11 compliance. Use for document control procedures, change control workflows, and electronic signature compliance.

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An end-to-end method for drafting and finalising a complex, multi-pillar regulated fintech agreement — from intake to signature. Authored from a senior fintech lawyer's manual: a licensed payment-services provider engaging a counterparty across agent cash-in/cash-out, QR payments, wallet e-payments, and a marketplace, each with its own regulatory profile. Runs five phases and fourteen steps: regulatory mapping (activity-to-licence matrix, grey-zone classification gates), architecture (framework-plus-sub-agreement structure, ring-fenced marketplace), the regulatory–commercial balance (what flexes vs what cannot), core drafting (authority, float mechanics, hard-coded regulator caps, liability — all tracking control), execution-blocker triage, and a pre-signature check closing open blockers as conditions precedent. It refuses to invent licence-specific values or draft a representation as true without executed evidence. Use it to structure, draft, negotiate, or review any regulated payments contract.

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This package provides a collection of functions designed for analyzing deconvolution of the bulk sample(s) using an atlas of reference omic signature profiles and a user-selected model. Users are given the option to create or extend a reference atlas and,also simulate the desired size of the bulk signature profile of the reference cell types.The package includes the cell-type-specific methylation atlas and, Illumina Epic B5 probe ids that can be used in deconvolution. Additionally,we included BS

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mastR is an R package designed for automated screening of signatures of interest for specific research questions. The package is developed for generating refined lists of signature genes from multiple group comparisons based on the results from edgeR and limma differential expression (DE) analysis workflow. It also takes into account the background noise of tissue-specificity, which is often ignored by other marker generation tools. This package is particularly useful for the identification of g

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Generate SuperSigs (supervised mutational signatures) from single nucleotide variants in the cancer genome. Functions included in the package allow the user to learn supervised mutational signatures from their data and apply them to new data. The methodology is based on the one described in Afsari (2021, ELife).

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Programmatic inbox management for Smartlead. Enable/disable warmup with correct ramp settings, set signatures in bulk, tag inboxes (active vs insurance), and pull inbox health dashboards. Use after creating a new batch of inboxes via /zapmail-domain-setup-public, or when managing an existing Smartlead account at scale. Triggers on "turn on warmup", "set signatures", "tag inboxes", "inbox health", "set up new inboxes".

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Use for the owner's personal creator-content thumbnails and covers for short video, Bilibili, Douyin, WeChat, or similar platforms from a title, summary, established real portrait, kangaroo IP, product Logo, screenshot, or app reference. It enforces the owner's visual signature, runs a four-concept selection stage, then five responsive platform ratios. Do not use for generic clients, book or album covers, slide title pages, generic posters or social cards, article body illustrations, document headers, website hero art, or unrelated image edits unless the user explicitly invokes cover-skill and accepts the personal-signature rules.

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Audit cryptography implementation — algorithm choice, key sizes, KDF parameters, IV/nonce handling, signature verification, randomness, TLS configuration, and key rotation. Deeper than owasp-audit A02. Use when the user mentions 'crypto review,' 'cryptography audit,' 'encryption review,' 'KDF,' 'PBKDF2,' 'Argon2,' 'bcrypt cost,' 'IV reuse,' 'nonce reuse,' 'AES mode,' 'AES-GCM,' 'AES-ECB,' 'signature verification,' 'TLS configuration,' 'cipher suites,' 'key rotation,' 'libsodium,' 'BoringSSL,' or 'is this crypto right.'

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Nature figure preparation: resolution (300+ DPI), formats (AI/EPS/TIFF), RGB color, Helvetica/Arial fonts, lowercase panel labels, image integrity requirements.

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論文投稿用の出版品質グラフ・図表を作成するメタスキル。 「論文用のグラフを作って」「Nature用の図を作成」「出版品質の可視化」等のリクエストで発動。

Use when users ask to 找文献、做文献检索、查论文、查临床试验、核验引用、去重文献、设计 PubMed/MeSH 检索式、追踪上下游引文、解析 DOI/PMID/PMCID/arXiv/OpenAlex/Semantic Scholar/NCT ID， 或导出 RIS、BibTeX、NBIB、ENW；also use for multi-source academic search, citation verification, citation graphs, trial registration search, research workflows, or DeepSeek Harness academic-search MCP setup.

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Validate API consistency between two versions of Python libraries. Use when you need to compare API behavior, signatures, and exceptions between library versions to identify breaking changes, incompatible modifications, and behavior differences. The skill performs static analysis of Python code, compares function signatures, class definitions, parameter types, return types, and generates a detailed JSON report with breaking changes, warnings, and migration guidance. Supports Python libraries and packages.

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Validate API consistency between two versions of Java libraries. Use when you need to compare API behavior, signatures, and exceptions between Java library versions to identify breaking changes, incompatible modifications, and behavior differences. The skill performs static analysis of Java code, compares method signatures, class definitions, interface changes, parameter types, return types, exception declarations, and generates a detailed JSON report with breaking changes, warnings, and migration guidance. Supports Java libraries and packages.

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Update Java test classes and methods to work with new code versions after refactoring or modifications. Use when code changes break existing tests due to signature changes, refactoring, or behavior modifications. Takes old and new code versions plus old tests as input, and outputs updated tests that compile and pass against the new code. Handles method signature changes, class refactoring, assertion updates, and mock modifications.

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Think and work like an expert Astrobiologist. Use when a task calls for Astrobiologist judgment. Reasons from habitability, redox disequilibrium, and Bayesian biosignature frameworks through Mars (Perseverance, Viking perchlorate lessons), Europa Clipper ocean worlds, agnostic signatures and the Ladder of Life Detection, while treating abiotic mimics, preservation, and LUCA phylogenomics as constraints—not templates—for extraterrestrial life.

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Test payment and checkout flows end to end against PSP sandboxes — Stripe first, with the general pattern for Adyen/Braintree/PayPal. Covers Stripe test-mode card numbers and their decline codes, the 3DS/SCA challenge flow and its nested-iframe handling in Playwright, test clocks for subscription/billing-cycle simulation, webhook testing (stripe listen/trigger, signature verification, idempotency), failed/retried payments and refunds, and never using real cards. Use when: "test Stripe checkout," "payment test," "3DS test," "test webhook signature," "test subscription renewal," "test clock," "refund test," "decline card test," "checkout E2E." Not for: General API contract testing of non-payment endpoints — api-testing. PCI-DSS/regulatory compliance audit — compliance-testing. Related: api-testing, playwright-automation, compliance-testing, test-data-management, qa-project-context.

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DSPy is a Python framework from Stanford NLP that replaces hand-written prompts with code: you declare LLM tasks as typed signatures, compose them into modules, and let optimizers (BootstrapFewShot, MIPROv2, GEPA) tune the prompts and few-shot examples against your metric. Use when the user asks about DSPy, signatures, ChainOfThought, ReAct, teleprompters or optimizers, or wants to stop hand-tuning prompts.

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Expert in on-chain privacy technologies - ZK-SNARKs, ZK-STARKs, mixers, stealth addresses, ring signatures, and confidential transactions for building privacy-preserving blockchain applicationsUse when "privacy, zero knowledge, zk-snark, zk-stark, mixer, stealth address, ring signature, confidential transaction, tornado, private transaction, anonymous, unlinkability, privacy, zero-knowledge, zk-snarks, zk-starks, mixers, stealth-addresses, tornado-cash, zcash, confidential" mentioned.

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This skill should be used when the user asks to "minimize the repro path", "/minimize", "shrink the crash steps", "精简复现路径", "找最小复现", "把 12 步压成 3 步", or wants to compress a recorded crash repro_path into the shortest sequence that still reproduces the same crash signature. Drives live Android replay via mobile-mcp + ui-mcp + log-mcp, validates each candidate subset with analyzer-mcp's signature, and updates the session's crash record with the verified minimal path; iOS sessions use the static fallback because ui-mcp replay is Android-only.

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Exploit JSON Web Tokens (JWT) by implementing the 'None' algorithm attack. This skill details how to bypass authentication mechanisms when a server improperly accepts JWTs with the `alg` header set to `none`, allowing attackers to forge tokens without a valid signature.

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Turns reverse-engineering findings into durable YARA detections: selecting stable code constructs and constants over volatile strings, extracting opcode/byte patterns with wildcards, and validating rules for low false positives. Activates for requests to write a YARA rule from reversed code, create a detection signature, or convert RE findings into hunting rules.

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Uses YARA to classify and triage samples at scale: applying rule sets, reading matches and string offsets, tuning for false positives, and organizing rules for malware family identification. Activates for requests to scan files with YARA, apply YARA rules, or classify samples by signature.

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