「ratios」の検索結果

Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.

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Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.

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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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Infers genetic super-population ancestry from a 23andMe/AncestryDNA file and computes ancestry-stratified odds ratios with an exploratory Ancestry Elevation Score (AES) showing where ancestry-specific GWAS effect sizes diverge from European reference estimates.

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This skill calculates key financial ratios and metrics from financial statement data for investment analysis

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Determines unilateral vs bilateral aldosterone excess based on cortisol-corrected aldosterone ratios from adrenal venous sampling, with ratio >4:1 indicating unilateral excess, ratio 3:1 suggestive of bilateral hypersecretion, and interpretation dependent on cosyntropin stimulation protocol used during sampling. Use when analyzing AVS results to guide surgical vs medical treatment decisions; triggers include 'AVS lateralization ratio', 'cosyntropin-stimulated AVS', 'aldosterone-to-cortisol ratio >4:1', and 'ratio 3:1 suggestive of bilateral disease'.

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Inspect codebases w/ pygount: LOC, languages, ratios.

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Load this skill whenever the project contains text, UI components, icons, form controls, data visualisations, or focus indicators — in short, almost every project. Under no circumstances hard-code colour values without verifying contrast ratios. Absolutely always ensure text meets 4.5:1, large text meets 3:1, and non-text UI elements meet 3:1 against adjacent colours. Test in light mode, dark mode, and forced-colors (high contrast) mode.

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AI image generation with OpenAI GPT Image 2, Azure OpenAI, Google, OpenRouter, DashScope, Z.AI GLM-Image, MiniMax, Jimeng, Seedream, Replicate and Agnes APIs. Supports text-to-image, reference images, aspect ratios, and batch generation from saved prompt files. Sequential by default; use batch parallel generation when the user already has multiple prompts or wants stable multi-image throughput. Use when user asks to generate, create, or draw images.

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This skill calculates key financial ratios and metrics from financial statement data for investment analysis

日本語の概要は準備中です。原文の説明を表示しています。

Builds SOC performance metrics and KPI tracking dashboards measuring Mean Time to Detect (MTTD), Mean Time to Respond (MTTR), alert quality ratios, analyst productivity, and detection coverage using SIEM data. Use when SOC leadership needs operational visibility, continuous improvement tracking, or executive-level reporting on security operations effectiveness.

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Professional financial analysis skill for investment decisions, budgeting, financial statement analysis, and business plan evaluation. Use this skill when you need to analyze financial ratios (profitability, safety, efficiency), calculate DCF/NPV/IRR valuations, perform budget variance analysis, or conduct sensitivity/scenario analysis. Triggers include "analyze financial statements", "calculate DCF", "investment evaluation", "budget variance", "財務分析", "投資評価", "予算差異分析".

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Generate images using AI models — Gemini, DALL·E, Stable Diffusion, Midjourney, Flux, Leonardo, Ideogram, and more. MCP bridge tools are primary; the Design Stack media worker is the fallback for advanced providers. Covers prompt engineering, model selection, size/aspect ratios, style parameters, batch generation, multi-site awareness, and WordPress integration. Use when you need to create hero images, social graphics, product mockups, brand illustrations, or any visual asset for marketing, social media, or e-commerce.

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Use when working with Bunny Cdn — bunny.net CDN management covering pull zones, storage zones, edge rules, cache configuration, and bandwidth analytics. Use when managing Bunny CDN pull zones, analyzing traffic patterns, configuring edge rules, monitoring cache hit ratios, or managing Bunny storage for origin content.

日本語の概要は準備中です。原文の説明を表示しています。

Inspect codebases w/ pygount: LOC, languages, ratios.

日本語の概要は準備中です。原文の説明を表示しています。

Transform, resize, crop, reformat, and optimize images on demand via Netlify Image CDN's /.netlify/images endpoint. Use when adding responsive images, generating thumbnails, converting formats (avif/webp/png), cropping to aspect ratios, tuning image quality, creating blurred placeholders, allowlisting remote image domains, serving user-uploaded images, or wiring framework image components (Next.js, Astro, Nuxt, Angular, Gatsby) to Netlify. Triggers on tasks like "optimize images", "add image thumbnails", "resize images on the fly", "serve images from an external domain", or "add blur placeholders".

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Write and improve prompts for Qwen-Image-2.1, Alibaba's open-weight image generation and editing model. Use whenever the user wants to generate or edit images with Qwen-Image / Qwen-Image-2.1 / Qwen-Image-Edit, asks for help prompting any Qwen image model, needs readable text rendered inside an image (posters, signs, UI mockups, infographics), wants to combine several reference images into one, or asks about aspect ratios, styles, or camera settings for Qwen image generation — even when they are only choosing an image model for a text-heavy graphic and have not named the model yet.

日本語の概要は準備中です。原文の説明を表示しています。

Inspect codebases w/ pygount: LOC, languages, ratios.

日本語の概要は準備中です。原文の説明を表示しています。

Builds SOC performance metrics and KPI tracking dashboards measuring Mean Time to Detect (MTTD), Mean Time to Respond (MTTR), alert quality ratios, analyst productivity, and detection coverage using SIEM data. Use when SOC leadership needs operational visibility, continuous improvement tracking, or executive-level reporting on security operations effectiveness.

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Configures the rollout shape of a PostHog experiment — the variant split (50/50, 80/20, A/B/C ratios), the overall rollout percentage that gates how many users enter the experiment, and the disambiguation when a percentage like "roll out to 25%" could mean either. Use when the user mentions a rollout percentage, variant split, or traffic distribution; gives a ratio like 60/40, 70/30, or 80/20; asks "who sees the test variant?"; wants to increase, decrease, or change the rollout or split on a draft or running experiment; weighs equal vs uneven splits; or proposes a mid-experiment split change (often an anti-pattern that needs reset or end-and-restart).

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Statistical modeling — linear/logistic/ordinal/Poisson regression, ANOVA, Kruskal-Wallis, chi-square, Mann-Whitney, Cox survival, spline fits (R `ns()`), odds ratios, Cohen's d, F-statistic, p-value computation. Specializes in clinical-trial AE analysis (SDTM DM/AE), severity ordinal regression, and per-feature stat workflows.

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Diagnostic test / biomarker accuracy — sensitivity, specificity, PPV, NPV, likelihood ratios, accuracy from a 2x2 table; ROC curve, AUC, and the optimal cutoff (Youden) for a continuous biomarker; and post-test probability via Bayes. Use when you have test results vs a gold standard (binary 2x2, or a continuous score + true labels) and need to judge how good the test is, pick a threshold, or compute the probability of disease given a result. Emphasizes the prevalence-dependence of PPV/NPV.

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