「sequence analysis」の検索結果

Uncover root causes through recursive Why questioning and consequence exploration. Use before acting on problems.

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Plan, write, art-direct, generate, and package a coherent 2-10 image minimal-zine social series from notes, articles, photographs, travel stories, products, reviews, cultural topics, data, PDFs, or mixed subjects. Use for Xiaohongshu/小红书图片, Instagram carousels, social visual essays, recommendation posts, photo diaries, evidence-backed explainers, or any multi-image editorial sequence. Produces analysis, card roles, subject-aware composition, saved prompts, real raster images, natural caption copy, evidence provenance when needed, and series-level QA.

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Distributional analysis of environmental benefits and burdens across communities. Covers the historical origins of environmental justice in the U.S. civil rights tradition, siting and exposure disparities, indigenous rights and land stewardship, climate justice at global and intergenerational scales, procedural vs. distributional vs. recognition justice, and the environmental justice screening tools used by regulators. Use when analyzing who bears environmental harm and who receives environmental benefit, or when designing interventions whose distributional consequences matter.

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Structured approaches to decisions under uncertainty and complexity. Covers expected value, decision trees, multi-criteria decision analysis, System 1 vs System 2 allocation, pre-mortems, reversible vs irreversible decisions, and the distinction between good decisions and good outcomes. Use when choosing among alternatives with uncertain or multi-dimensional consequences, especially when the stakes justify a deliberate rather than intuitive process.

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Use this skill for any marketing research, product positioning, copywriting research, or audience profiling task. Triggers include: "research my product", "develop my value proposition", "profile my avatar", "understand my market", "create a unique mechanism", "market awareness", "market sophistication", "ideal customer profile", "ICP research", "positioning research", "copywriting research", "features and benefits", "competitor research", "competitive analysis", or any request to deeply research a product or audience for marketing purposes. Use this skill proactively whenever a user wants to prepare materials for sales copy, landing pages, ads, email sequences, or any persuasion-focused content. If a user says "help me understand my market", "I need to figure out my messaging", "who is my customer", or "what makes my product different", this skill applies immediately.

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Internal downstream skill for ctf-sandbox-orchestrator. CTF-sandbox workflow for packet capture analysis, session reconstruction, application-protocol decoding, stream reassembly, beacon timing, and packet-to-process correlation. Use when the user asks to analyze a PCAP, rebuild TCP or UDP sessions, decode HTTP, WebSocket, DNS, custom C2, or binary protocols, extract transferred artifacts, or tie packet sequences to host or malware behavior. Use only after `$ctf-sandbox-orchestrator` has already established sandbox assumptions and routed here.

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Constructs accretion/dilution analysis with pro forma financials, synergy phasing, and purchase price allocation. Use when modeling merger outcomes, calculating EPS accretion, or analyzing deal structures.

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Evaluates key person clause triggers, consequences, and cure mechanics in partnership documentation. Use when analyzing key person provisions, assessing management stability risk, or structuring departure protections.

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Build sequential (stateful) logic circuits including latches, flip-flops, registers, counters, and finite state machines. Covers SR latch, D and JK flip-flops, binary/BCD/ring counters, and Mealy/Moore FSM design with clock signal and timing analysis. Use when a circuit must remember past inputs, count events, or implement a state-dependent control sequence.

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Optimizes multi-step conversion flows including signup, onboarding, upgrade, and checkout. Maps each step, identifies friction and drop-off risks, then recommends specific copy/UX changes with A/B test plans. Use when someone says 'signup flow', 'onboarding optimization', 'checkout conversion', 'paywall optimization', 'activation rate', 'funnel analysis', 'why are users dropping off', 'registration flow', 'trial conversion', 'free to paid', 'upgrade flow', 'user journey', or wants to improve any multi-step user journey. If they mention steps, screens, or a sequence that leads to signup, payment, or activation, this is the skill. Even casual mentions like 'users aren't finishing signup' or 'our onboarding sucks' should trigger this. Use this instead of page-cro when the problem spans multiple screens rather than a single page.

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Assemble a finished piece from human-written fragments via an orchestrated two-loop pipeline - an assembly loop (assembler + cold reviewer) that sequences the fragments into a draft, then a polish loop (polisher + cold reviewer), then frequency analysis and a catalog-deslop pass with a regression gate. Two modes with opposite fidelity contracts - stitch mode preserves the author's exact wording, narrative mode preserves every idea but may rewrite freely. Use when the user says "mosaic", "assemble my fragments", "stitch these notes into a post", or provides a fragments file to turn into a finished piece. For writing from a topic with research, use article-factory; for prose from scratch, use the prose skill.

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Audit workplace risk scoring systems and occupational safety programs -- evaluate job hazard analysis (JHA/JSA) methodology and task-level hazard identification, risk matrix calibration for likelihood and consequence scales, exposure assessment accuracy for chemical, noise, vibration.

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End-to-end bioinformatics analysis — sequence QC, alignment, and omics pipelines for research data.

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Council — 5 independent AI perspectives + mutual critique + synthesis (adapted from karpathy/llm-council for Claude Code). For high-stakes decisions where the answer does NOT follow unambiguously from the data — go/no-go before real consequences, critiquing a methodology, choosing between competing approaches, pressure-testing a conclusion you're attached to, designing risk controls. NOT for log/data analysis (the council has no data access) and not for factual lookups. Triggers — "convene the council", "run it past the council", "go/no-go", "pressure-test this".

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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

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Trim multiple sequence alignments using ClipKIT, trimAl, BMGE, Divvier, or HMMcleaner with mode selection guidance per downstream goal. Use when removing unreliable columns or contaminating residues before phylogenetic inference, HMM building, or selection analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.

日本語の概要は準備中です。原文の説明を表示しています。

Call this skill when faced with "wicked problems", complex challenges, or when a user asks for strategic innovation, root-cause analysis, or long-term problem solving. Do not use for simple, linear tasks. This skill forces the agent to bypass superficial symptoms, map the entire ecosystem, and anticipate second-order consequences before proposing an intervention.

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This skill covers detecting anomalies in Modbus/TCP and Modbus RTU communications in industrial control systems. It addresses function code monitoring, register range validation, timing analysis, unauthorized client detection, and deep packet inspection for malformed Modbus frames. The skill leverages Zeek with Modbus protocol analyzers, Suricata IDS with OT rules, and custom Python-based detection using Markov chain models for normal Modbus transaction sequences.

日本語の概要は準備中です。原文の説明を表示しています。

Retrieve and analyze AlphaFold predicted structures for a protein. Use when the user provides a specific UniProt Accession ID and wants structural confidence metrics (pLDDT), domain boundary analysis, or disorder assessment. Do not use if the user only has a protein name, gene name, or amino acid sequence — ask for a UniProt ID first.

日本語の概要は準備中です。原文の説明を表示しています。

This skill covers detecting anomalies in Modbus/TCP and Modbus RTU communications in industrial control systems. It addresses function code monitoring, register range validation, timing analysis, unauthorized client detection, and deep packet inspection for malformed Modbus frames. The skill leverages Zeek with Modbus protocol analyzers, Suricata IDS with OT rules, and custom Python-based detection using Markov chain models for normal Modbus transaction sequences.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

日本語の概要は準備中です。原文の説明を表示しています。