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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

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Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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Guides MongoDB users through implementing and optimizing Atlas Search (full-text), Vector Search (semantic), and Hybrid Search solutions. Use this skill when users need to build search functionality for text-based queries (autocomplete, fuzzy matching, faceted search), semantic similarity (embeddings, RAG applications), or combined approaches. Also use when users need text containment, substring matching ('contains', 'includes', 'appears in'), case-insensitive or multi-field text search, or filtering across many fields with variable combinations. Provides workflows for selecting the right search type, creating indexes, constructing queries, and optimizing performance using the MongoDB MCP server.

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Generate read-only MongoDB queries (find) or aggregation pipelines using natural language, with collection schema context and sample documents. Use this skill whenever the user asks to write, create, or generate MongoDB queries, wants to filter/query/aggregate data in MongoDB, asks "how do I query...", needs help with query syntax, or discusses finding/filtering/grouping MongoDB documents. Also use for translating SQL-like requests to MongoDB syntax. Does NOT handle Atlas Search ($search operator), vector/semantic search ($vectorSearch operator), fuzzy matching, autocomplete indexes, or relevance scoring - use search-and-ai for those. Does NOT analyze or optimize existing queries - use mongodb-query-optimizer for that. Does NOT handle aggregation pipelines that involve write operations. Requires MongoDB MCP server.

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Automate versioning and changelog generation using semantic versioning principles. Configure release automation, version bumping, and changelog tools. Use when implementing version management or automating release processes.

日本語の概要は準備中です。原文の説明を表示しています。

Email automation flows — welcome series, abandoned cart, post-purchase, win-back, browse abandonment

日本語の概要は準備中です。原文の説明を表示しています。

Database schema design, optimization, and migration patterns for PostgreSQL, MySQL, and NoSQL databases. Use for designing schemas, writing migrations, or optimizing queries.

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Systematic approach to diagnosing and fixing errors

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SEO and GEO (Generative Engine Optimization) for organic traffic and AI search visibility. Covers technical SEO, content SEO, keyword strategy, schema markup, and optimization for AI search engines (ChatGPT, Perplexity, Gemini). Use when the user needs SEO audit, keyword research, GEO optimization, schema markup, or says 'SEO', 'search optimization', 'keywords', 'organic traffic', 'AI search', 'GEO', or 'rank higher'.

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MANDATORY for every coding agent (Claude Code, Codex, or any other) — keep this repository's documentation in sync after any change to behavior, configuration, interfaces, events, schema, or features. Use automatically at the end of change-sets that alter an env var, event type, hook or state behavior, API, schema, WebSocket message, MCP tool, CLI command, or user-facing feature, and whenever the user asks to update documentation.

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Hit the Cloudflare REST API directly for operations that wrangler and MCP can't handle well. Bulk DNS, custom hostnames, email routing, cache purge, WAF rules, redirect rules, zone settings, Worker routes, D1 cross-database queries, R2 bulk operations, KV bulk read/write, Vectorize queries, Queues, and fleet-wide resource audits. Produces curl commands or scripts. Triggers: 'cloudflare api', 'bulk dns', 'custom hostname', 'email routing', 'cache purge', 'waf rule', 'd1 query', 'r2 bucket', 'kv bulk', 'vectorize query', 'audit resources', 'fleet operation'.

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Build Google Apps Script automation for Sheets and Workspace. Custom menus, triggers (onEdit / time-driven / form submit), dialogs, sidebars, email batches, PDF export, external API. Use whenever the user wants to automate a Google Sheet, build a Sheets menu / sidebar / dialog, hit a Sheets row from email or a webhook, schedule a Sheets workflow, or asks 'how do I script this in Sheets'.

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Expert guidance for the cross-platform Tabular Editor CLI (the `te` binary, currently in preview) that manages Power BI / Analysis Services semantic models from the terminal on macOS, Linux, and Windows. Use when the user mentions the `te` CLI or "Tabular Editor CLI" (not the "2"), or runs a `te <command>` to scaffold, inspect, edit, validate, run BPA on, query, deploy, refresh, test, or migrate a semantic model. Not for the legacy Windows-only `TabularEditor.exe` (TE2).

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Automatically invoke this skill whenever the user asks to refresh a semantic model or a dataset. Can also be used to manage, optimize, troubleshoot, or configure a refresh or a refresh schedule.

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Design and build complete web experiences from scratch — award-level product and marketing pages, cinematic scroll-directed sites where the page is directed like a film, and multi-screen products (app, dashboard, admin, settings, onboarding, docs site) built as one design system with every component, state and route in one style. Use whenever the user wants to create or redesign a landing page, website, hero section, portfolio, promo or product page; wants scroll animations, storytelling pages, or a site that feels like a movie; or says "make it beautiful", "make it wow", "cinematic", or "design system" — even if they name no technique. Generates its own assets via local CLIs (images, video frames, depth maps, 3D), and gates every ship with an executable anti-slop linter and a screenshot verification loop. Not for polishing a UI someone else built, and not for backend-only work.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to monitor brand mentions, detect trademark infringement, or set up brand monitoring. Also use when the user mentions "brand monitoring," "brand watch," "trademark watch," "brand mentions," "impersonation detection," "counterfeit detection," or "brand abuse monitoring." For enforcement, use brand-protection.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to fix indexing issues from Search Console, use noindex, or implement Google Indexing API. Also use when the user mentions "fix indexing," "not indexed," "Crawled - currently not indexed," "discovered - currently not indexed," "index coverage," "noindex," "noindex tag," "pages not indexed," "why not indexed," "request indexing," or "Google Indexing API." For sitemap, use xml-sitemap.

日本語の概要は準備中です。原文の説明を表示しています。

When the user faces brand impersonation, fake websites, phishing sites, or trademark infringement. Also use when the user mentions "fake site," "impersonation," "phishing site," "trademark infringement," "domain squatting," or "brand abuse." For monitoring, use brand-monitoring.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to optimize for Featured Snippets, Position Zero, or snippet extraction. Also use when the user mentions "featured snippet," "position zero," "snippet optimization," "answer box," "definition box," "list snippet," "table snippet," "paragraph snippet," "PAA optimization," or "win position zero." For schema, use schema-markup. For step-by-step HowTo sections (lists, copy), use howto-section-generator.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to write, generate, or create article body content—blog post body, long-form content, how-to guide, listicle. Also use when the user mentions "write article," "article content," "blog post content," "article body," "long-form content creation," "generate article," "article draft," "how-to guide content," "listicle content," "information gain," or "content density." For single post page structure, schema, and SEO metadata, use article-page-generator. For blog index/listing page, use blog-page-generator. For short ad, landing, or email copy, use copywriting.

日本語の概要は準備中です。原文の説明を表示しています。

Use when making a trailer, cutscene, cinematic or short film in Unreal Engine 5.8 with Sequencer: shot lists, master and shot sequences, cameras, lenses, depth of field, camera cuts, spawnables, character animation in shots, per-shot lighting, Movie Render Graph or Movie Render Queue EXR renders, "render darker than the viewport", "first frames pop", "last frame missing", ACES or OCIO to DaVinci Resolve, the 180-degree rule, Sequencer Python, or reviewing a cut.

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Designing lead magnets that earn the email. The discipline of building gated content (ebooks, templates, checklists, swipe files, mini-courses, free tools) that delivers genuine standalone value while qualifying the lead and warming them for what comes next. Honest about thin-bait (overpromises, underdelivers), kitchen-sink-resource (everything, helps with nothing), and earned-value-magnet (delivers standalone value while qualifying the lead). Triggers on lead magnet, gated content, opt-in offer, ebook, checklist, template, swipe file, mini-course, free tool, content upgrade, freebie, opt-in, list-building offer. Also triggers when an audience is being asked for an email and the offer attached to that ask needs design discipline, when previous lead magnets converted but did not produce qualified leads, or when a lead magnet is being scoped for the first time.

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How to actually instrument product analytics correctly. Event taxonomy, property design, naming conventions, schema versioning, identity stitching, funnel design, retention cohorts, North Star metric selection, dashboard hygiene, instrumentation debt, and the failure modes that produce data nobody trusts. Triggers on product analytics setup, event taxonomy, tracking plan, instrumentation, schema versioning, North Star metric, retention cohorts, funnel design, naming conventions, instrument new feature, audit existing analytics, dashboard reconciliation, instrumentation debt, Mixpanel setup, Amplitude setup, PostHog setup, warehouse-native analytics. Also triggers when the team has data but cannot trust it, or when designing instrumentation for a new feature, or when auditing an existing setup that has drifted.

日本語の概要は準備中です。原文の説明を表示しています。