「engineer」の検索結果

Audit a repo's agent context — CLAUDE.md files, codebase docs, skills, and tool/MCP designs — against Anthropic's Claude 5 context-engineering guidance ("unhobbling": Anthropic cut ~80% of Claude Code's system prompt with no eval loss). Finds overconstraint, conflicting instructions, redundancy, stale facts, and missing "unknown knowns"; produces a scored findings report with concrete rewrites, then applies approved fixes. Use when someone says "audit my CLAUDE.md", "context audit", "unhobble this repo", "review our agent docs/skills/tools", or after upgrading to Claude 5-generation models.

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Inspect an agent repository and optional traces, interview the user, write reviewed Task Specs, build and audit Harbor tasks, and bootstrap reusable project World Knowledge Skills. Use for agent evals, benchmark design, Task generation, controlled Environments, synthetic data, Verifiers, Harbor runs, calibration, or continuous benchmark maintenance.

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Reverse-engineer how competitors do programmatic SEO. Detects URL pattern clusters (vs/, integrations/, for-{industry}/), estimates page count per pattern, analyzes template quality, infers which patterns actually drive traffic, and identifies gaps you can exploit. Outputs a competitive pSEO landscape report.

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Analyze a website's SEO visibility, keyword rankings, traffic estimates, and competitive positioning. Uses web search probes, SimilarWeb (free tier via web), and site: queries to build an SEO profile without requiring paid tool subscriptions. Useful for competitive intel, gap analysis, and reverse-engineering a company's organic acquisition strategy.

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Scrape competitor ads from Meta, TikTok, Google, and LinkedIn ad libraries, analyze creative patterns (hooks, formats, CTAs), reverse-engineer landing page funnels, and produce a strategic teardown with vulnerability analysis and counter-play recommendations. Use when you need to understand the competitive ad landscape, find new creative directions, or identify weaknesses in a competitor's paid strategy.

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Reverse-engineer a company's sales and marketing tech stack from public signals. Detects CRMs, cold email tools, people databases, ad pixels, email delivery services, and outbound sending domains via DNS records, website source inspection, Apify technology profiling, blacklist checks, and public spam complaint searches. Works on single companies or batches. Outputs a structured markdown report per company.

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Orchestrate Project Osmos for long-running Fabric and OneLake data-engineering outcomes, including task status, messages, follow-ups, cancellation, and deletion. Osmos tasks are remote service tasks, not local background agents. In Fabric portal Copilot, direct interaction is unsupported; point users to GitHub Copilot CLI. Use spark-cli for direct non-Osmos Spark work. Triggers: "Project Osmos", "Project Osmos task status", "check my Osmos task".

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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

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Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Designs pegRNAs and nicking guides for prime editing (PE) -- choosing the nick/strand, tuning the primer-binding site (PBS) and reverse-transcription template (RTT) as a per-locus panel, selecting the PE system (PE2/PE3/PE3b/PE4/PE5/PEmax/PE7), adding MMR-evading and PAM-disrupting silent edits, appending epegRNA 3' motifs (tevopreQ1/mpknot), and ranking with PRIDICT/DeepPrime. Covers twinPE/PASTE for large insertions and the prime-vs-base-editing decision. Use when designing a scarless point mutation, small insertion/deletion, or any of the 12 base conversions without a double-strand break, when efficiency is low and MMR inhibition or pegRNA stabilization is needed, or when routing a large insertion to an integrase method. Generic guide scoring and base editing are separate skills.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

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This skill should be used when writing, reviewing, or refactoring Python code. Covers code integration, idiomatic patterns, docstring formatting, anti-abstraction rules, and software engineering basics.

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Build internal developer platforms (IDPs) with self-service infrastructure, golden paths, and developer portals using Backstage, Crossplane, and score.

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Build production LLMOps platforms with CI/CD, model promotion workflows, evaluation gates, rollback, and governance across cloud and self-hosted inference.

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Building applications with Large Language Models - prompt engineering, RAG patterns, and LLM integration. Use for AI-powered features, chatbots, or LLM-based automation.

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Validate API documentation against quality standards. Use when you need to verify generated docs are complete and correct.

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Generate an interactive tree visualization of your codebase. Use when exploring a new repo or understanding project structure.

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Generate API endpoint code and documentation from specifications. Use when the user wants to create new API endpoints, generate route handlers, scaffold REST APIs, or produce OpenAPI/Swagger specs from code.

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Perform a comprehensive code health check on a directory. Use when the user asks to analyze code quality, find issues, or get a health report.

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Generate API documentation from code. Use when the user wants to document APIs, create API reference, generate endpoint documentation, or needs help with OpenAPI/Swagger specs.

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Generate API documentation from a route manifest. Use when you have a list of discovered routes and need to produce markdown documentation.

日本語の概要は準備中です。原文の説明を表示しています。