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概要と使いどころ
Provider-independent storyboard and previsualization direction for AI agents turning briefs, scripts, treatments, ads, films, social videos, and generated-media concepts into shot-by-shot boards, animatics, previs plans, camera/blocking/movement direction, reference packs, AI image/video prompt plans, review workflows, continuity checks, and production handoffs.
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Provider-independent production workflow for AI avatar spokesperson videos, including presenter briefs, consent and likeness rights, disclosure and platform labeling, casting, localization, performance direction, brand fit, claims review, lip-sync/audio QA, accessibility, approvals, and delivery packages. Use when creating synthetic presenter videos, corporate explainers, training modules, sales/support avatars, localization spokespeople, product announcements, compliance videos, or social avatar clips.
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Apply security-conscious thinking when generating or modifying code. Enforces trust boundary awareness, input validation, injection prevention, secrets management, and defense-in-depth authorization. Use when generating code that handles user input, authentication, authorization, database queries, external APIs, or file operations, or when the user mentions 'security review', 'secure this', 'check for vulnerabilities', 'trust boundary', 'input validation', or 'OWASP'. Loaded automatically by the code-generating molecules (code-forge, refactor-safely, bug-fix). This skill governs the security posture of generated code -- not architecture (see architecture) and not code craft (see clean-code).
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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.
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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.
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Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.
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Build circular genome visualizations using circlize (R), pyCirclize (Python), or Circos (Perl CLI) with ideogram tracks, multi-data tracks (scatter, histogram, heatmap), chord/link arcs for interactions, and explicit circos.clear() between plots. Covers when circular is appropriate vs when Cartesian wins (Cleveland-McGill 1984), karyograms, and chromosome adjacency in chord diagrams. Use when adjacency on the circle conveys meaning — chromosome-level overview, structural variants, Hi-C interactions, cross-genome comparisons.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.
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Create, manipulate, and convert bedGraph files for genome browser visualization. Covers bedGraph format, conversion to/from bigWig, normalization, and signal processing. Use when handling coverage and signal tracks from ChIP-seq, ATAC-seq, or RNA-seq.
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Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.
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Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics, multi-omics, pathway, metagenomics, database queries, visualization, workflows): search the index, locate the best-matching skill, fetch its SKILL.md, and follow it.
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Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.
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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for fine-mapping, colocalization, mediation, pleiotropy analysis, and Mendelian randomization.
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Design environment strategy for testing across dev, CI, preview, staging, and production — Docker Compose test infrastructure, multi-stage Dockerfiles, seed-data lifecycle, per-PR preview environments, production parity, and external-dependency stubbing at the HTTP boundary. Use when: "set up test environment," "docker-compose for tests," "per-PR preview environment," "staging parity," "spin up test infra," "environment tiers." Not for: choosing mock-vs-stub-vs-fake per dependency — use service-virtualization; factory and fixture data patterns — use test-data-management; pipeline/Actions config — use ci-cd-integration. Related: test-data-management, ci-cd-integration, contract-testing, service-virtualization.
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Implement consumer-driven contract testing with Pact-JS (v16). Covers consumer test writing, broker-driven provider verification, Pact Broker setup, can-i-deploy as a deployment gate, webhook-triggered verification, pending pacts, and schema-first vs consumer-first approaches (OpenAPI/Ajv, Schemathesis). Use when: "contract test," "Pact," "consumer-driven," "API contract," "provider verification," "can-i-deploy." Not for: stubbing or mocking a dependency to isolate a test — use service-virtualization; general REST/GraphQL endpoint assertions against your own API — use api-testing. Related: api-testing, service-virtualization, ci-cd-integration, test-environments.
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Create and manage test data with factory patterns, fixture strategies, data anonymization, and synthetic data generation. Covers Fishery (TypeScript), FactoryBot (Ruby), Factory Boy (Python), database seeding, cleanup strategies, and GDPR-compliant data handling. Use when: "test data," "fixtures," "factories," "seed data," "synthetic data," "test database," "data anonymization." Not for: migration/integrity testing of the DB itself — use database-testing; environment provisioning and database branching strategy — use test-environments. Related: test-environments, database-testing, api-testing, unit-testing.
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Build and visualize QA dashboards and reports with Allure Report, Grafana, and ReportPortal. Covers test execution visualization, stakeholder-facing quality reports, trend/flakiness panels, release-readiness gates, alerting, and CI integration for automated report generation. Use when: "test dashboard," "Allure," "test report," "quality dashboard," "Grafana," "ReportPortal," "test results visualization." Not for: defining which KPIs to measure or how to interpret them — use qa-metrics (this skill builds the panels; qa-metrics decides what they should show). Related: qa-metrics, ci-cd-integration, ai-bug-triage.
日本語の概要は準備中です。原文の説明を表示しています。
Optimize MATLAB code for better performance through vectorization, memory management, and profiling. Use when user requests optimization, mentions slow code, performance issues, speed improvements, or asks to make code faster or more efficient.
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Mine AI coding-agent session transcripts into structured, gate-validated GPU-kernel optimization records for the wiki. Use when asked to turn vibe-coding sessions, Codex rollout logs, or Claude Code project transcripts into wiki records; to summarise what a kernel-optimization session achieved; to build or extend a session-trace store; or to re-run and validate one. Also use when asked how a session-derived record's number, snippet, or provenance was established.
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Build Tier 1/2/3 cold outreach sequences differentiated by personalization depth and research signal strength during PRD v0.9 Go-to-Market. Triggers on requests to plan cold outreach, founder-led sales, or when user asks "cold email sequence", "outbound campaign", "founder outreach", "LinkedIn outreach", "Tier 1 personalization", "predictable revenue", "sales cadence", "BDR sequence". Outputs GTM-OUT-* sequence entries and lead-list references.
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Systematic analysis of Google Ads and Meta advertising spend to identify wasted budget. Produces actionable exclusion lists with thematic categorization and statistical validation. Use when onboarding new accounts, performing monthly hygiene, or preparing for budget optimization.
日本語の概要は準備中です。原文の説明を表示しています。