1,632 件 ・ 関連度順
概要と使いどころ
Unified verification: build→lint→test→type-check→coverage. Use for 'is everything green', 'run all checks', 'verify build'. Auto-called by mk:cook. NOT for lint/format only (see mk:lint-and-validate); NOT for test-to-requirement coverage mapping (see mk:nyquist).
日本語の概要は準備中です。原文の説明を表示しています。
Advanced vulnerability analysis principles. OWASP Top 10 baseline + current threat landscape awareness, Supply Chain Security, attack surface mapping, risk prioritization. Use when performing security audits, threat modeling, or OWASP reviews. NOT for STRIDE/CSO-mode infrastructure audits (see mk:cso).
日本語の概要は準備中です。原文の説明を表示しています。
Use when writing tests, running validation scripts, or (in TDD mode) enforcing red-green-refactor cycle. Activates during Phase 2 (Test) and Phase 3 (Build). NOT for coverage gap mapping (see mk:nyquist); NOT for sprint contract negotiation (see mk:sprint-contract).
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes ticket complexity and maps dependencies against an existing codebase before sprint planning. Triggers on 'how complex is this ticket', 'what should we work on first', 'can we fit this in the sprint', 'tech review before planning', 'plan the sprint'. NOT for writing implementation plans (see mk:plan-creator); NOT for scope/ambition review (see mk:plan-ceo-review).
日本語の概要は準備中です。原文の説明を表示しています。
Fast parallel codebase scouting. Spawns multiple Explore subagents to search directories simultaneously, returning a consolidated file map with architecture fingerprint, complexity estimates, and routing suggestions. Use before planning, debugging, or any task spanning multiple directories. NOT for reading a single known file in depth (use Read directly); NOT for semantic find-usages or go-to-definition.
日本語の概要は準備中です。原文の説明を表示しています。
Use when surfacing architectural friction and proposing deepening refactors (shallow modules → deep modules) for testability and AI-navigability. Triggers on "improve architecture", "find deepening opportunities", "where is this codebase shallow", "architecture review". Emits structured candidates + precise patches; delegates ALL rendering to mk:preview. NOT for diagram/HTML rendering (see mk:preview); NOT for trade-off deliberation (see mk:party); NOT for plan critique (see mk:plan-ceo-review).
日本語の概要は準備中です。原文の説明を表示しています。
Diagnose and optimize timing-critical Chisel RTL for FPGA implementation while preserving cycle semantics. Use for Vivado timing bottlenecks, long ready or admission paths, queue and issue selection, free-list bank mapping, priority encoders, one-hot arbitration, wide muxes, late-arriving forwarding or override data, high-fanout controls, cross-module predicates, register-boundary changes, emitted-Verilog inspection, or routed-DCP A/B analysis. Also use when a source-level simplification needs proof that it changes timing without changing architectural state.
日本語の概要は準備中です。原文の説明を表示しています。
Professional network graph analyst identifying Gladwellian superconnectors, mavens, and influence brokers using betweenness centrality, structural holes theory, and multi-source network reconstruction. Activate on 'superconnectors', 'network analysis', 'who knows who', 'professional network', 'influence mapping', 'betweenness centrality'. NOT for surveillance, discrimination, stalking, privacy violation, or speculation without data.
日本語の概要は準備中です。原文の説明を表示しています。
Expert landscape designer transforming yards through photo mapping, 3D visualization, seasonal planning, and deep plant knowledge. Specializes in fast-growing privacy screens (knows arborvitae pitfalls), architecture-appropriate design, outdoor living spaces, and realistic maintenance expectations. Activate on "landscape design", "yard design", "garden planning", "plant selection", "privacy screen", "outdoor living", "backyard makeover", "arborvitae", "hedge", "fast growing tree", "landscaping ideas". NOT for interior design (use interior-design-expert), hardscape construction (consult contractors), or lawn care chemicals (consult local experts).
日本語の概要は準備中です。原文の説明を表示しています。
Expert in drone systems, computer vision, and autonomous navigation. Specializes in flight control, SLAM, object detection, sensor fusion, and path planning. Activate on "drone", "UAV", "SLAM", "visual odometry", "PID control", "MAVLink", "Pixhawk", "path planning", "A*", "RRT", "EKF", "sensor fusion", "optical flow", "ByteTrack". NOT for domain-specific inspection tasks like fire detection, roof damage assessment, or thermal analysis (use drone-inspection-specialist), GPU shader optimization (use metal-shader-expert), or general image classification without drone context (use clip-aware-embeddings).
日本語の概要は準備中です。原文の説明を表示しています。
Design desktop window systems that feel native on macOS and Windows: split views, inspectors, auxiliary windows, tiling, snap-safe sizes, default placement, and chrome density. Use when a Tauri/Electron/WinUI/SwiftUI app feels awkward, overlapping, over-chromed, or generic, or when you need a real geometry contract for multiple surfaces. NOT for mobile layouts, marketing pages, or CSS-only component styling without multi-window or multi-pane behavior.
日本語の概要は準備中です。原文の説明を表示しています。
Plan database migrations before executing them: risk assessment, dependency mapping, multi-service sequencing, rollback budgets, and stakeholder communication plans. Use when deciding HOW to migrate, not when writing the actual DDL. NOT for: writing migration SQL (use database-migration-manager), data ETL pipelines (use data-migration-specialist), query optimization, or ORM configuration.
日本語の概要は準備中です。原文の説明を表示しています。
Master of text-based visual communication using ASCII art, Unicode box-drawing, and structured diagram notation. Creates clear, maintainable diagrams for systems, processes, hierarchies, relationships, and psychological structures. Proactively generates diagrams to enhance understanding. Activate on visualization needs, system architecture, process flows, psychological mapping, or when complex concepts would benefit from visual representation. NOT for photo editing, vector graphics, or GUI-based design tools.
日本語の概要は準備中です。原文の説明を表示しています。
Strategic analyst that maps competitive landscapes, identifies white space opportunities, and provides positioning recommendations. Use when users need competitive analysis, market positioning strategy, differentiation tactics, or "how do I stand out?" guidance across any domain (portfolios, products, services). NOT for market size estimation or financial forecasting.
日本語の概要は準備中です。原文の説明を表示しています。
Reads, inspects, and writes Flow Cytometry Standard (FCS) files from conventional, spectral, and mass cytometry (CyTOF), and parses FlowJo/Cytobank/Diva workspaces. Covers FCS 2.0/3.0/3.1/3.2 internals ($PnE linear-vs-log, $DATATYPE, $SPILLOVER vs SPILL vs $COMP, $TIMESTEP), channel/parameter metadata, the silent linearize/truncate defaults, and R (flowCore, flowWorkspace, CytoML) plus Python (FlowKit, readfcs) readers. Use when loading flow or mass cytometry data, mapping detector channels to antibodies, extracting the event matrix, choosing a reader, or bridging FCS to the scanpy/AnnData ecosystem before preprocessing.
日本語の概要は準備中です。原文の説明を表示しています。
Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair tracking, antibody-lot metadata recording, replicate concordance via deepTools multiBamSummary + plotCorrelation, IP enrichment QC via plotFingerprint and per-transcript IP/input ratio distributions, library-complexity saturation curves via PreSeq, and the explicit do-NOT-deduplicate convention for standard non-UMI MeRIP. Use when preparing paired IP and input BAM files for exomePeak2 / MeTPeak / MACS3 peak calling, evaluating MeRIP replicate concordance and IP enrichment, deciding whether to deduplicate (standard MeRIP typically NOT), choosing genome-vs-transcriptome alignment for downstream peak vs m6Anet workflows, recording antibody clone and lot metadata for cross-batch reconciliation, detecting failed IPs via saturation curves and IP/input distribution shape, or generating IP-over-Input bigWig tracks for visualisation.
日本語の概要は準備中です。原文の説明を表示しています。
Imports gene expression count matrices from featureCounts, HTSeq, STAR ReadsPerGene, Salmon/kallisto via tximport or tximeta, RSEM, 10X Genomics MTX/H5, AnnData H5AD, and RDS. Handles silent-miscounting traps (featureCounts -p v2.0.2 API break, STAR strandedness column choice, salmon NumReads-sum without tximport, RSEM non-integer expected_count, GENCODE _PAR_Y suffix, zero-length-transcript TPM divide-by-zero), and encodes the tximport countsFromAbundance decision tree with the "lengthScaledTPM is not TPM" warning. Use when assembling a gene-by-sample count matrix from aligner or quantifier output, importing salmon/kallisto for DESeq2 vs limma-voom, choosing strandedness column for STAR, debugging zero-count panics, or building tx2gene mapping.
日本語の概要は準備中です。原文の説明を表示しています。
Build clustered heatmaps for expression matrices and other features-by-samples data with rigorous distance/linkage/scaling choices, robust color mapping, optimal leaf ordering, and ComplexHeatmap/pheatmap/seaborn rendering. Covers the ward.D vs ward.D2 trap, the row-vs-column scaling decision, multi-track annotations, oncoPrint, and raster rendering for large matrices. Use when visualizing expression patterns across samples or identifying co-regulated clusters.
日本語の概要は準備中です。原文の説明を表示しています。
Preprocess CLIP-seq reads (eCLIP, iCLIP, iCLIP2, iCLIP3, irCLIP, PAR-CLIP, FLASH) with protocol-specific UMI extraction, adapter trimming, length filtering, and post-alignment PCR-duplicate collapse. Use when raw CLIP FASTQ must be turned into deduplicated, crosslink-preserving BAM input for peak calling; choosing between two-pass and single-pass adapter trimming; deciding minimum read length; or mapping UMI patterns to specific eCLIP/iCLIP/iCLIP2/iCLIP3 library preps.
日本語の概要は準備中です。原文の説明を表示しています。
Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.
日本語の概要は準備中です。原文の説明を表示しています。
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.
日本語の概要は準備中です。原文の説明を表示しています。
Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).
日本語の概要は準備中です。原文の説明を表示しています。
Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.
日本語の概要は準備中です。原文の説明を表示しています。