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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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Implement Swift Codable models for JSON and property-list encoding and decoding with JSONDecoder, JSONEncoder, CodingKeys, and custom init(from:) or encode(to:). Use when parsing API responses, remapping keys, flattening nested JSON, handling date or data decoding strategies, decoding heterogeneous arrays, or integrating Codable with URLSession, SwiftData, or UserDefaults.

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onboarding workflow for creating datasets and applications in Viking AI Search. Supports one-time import from local files (JSON, JSONL, CSV) and MySQL databases, plus scheduled incremental sync for append-only JSONL files and MySQL. All sources are first exported to a bootstrap JSONL file; backend-driven schema inference handles detection, and optional background sync keeps the dataset up to date as new data arrives.

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Use when planning many similar pages from a template and a data set: choosing the pattern, deciding whether the data can carry it, and avoiding the thin-content failure that gets page sets deindexed.

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Guides Metronome usage-based billing integration decisions — event ingestion (single and batch, idempotency, billable metrics), contract design (rate cards, overrides, dimensional pricing, products), invoicing lifecycle (grace periods, finalization, Stripe sync), credit and commit management (prepaid, postpaid, thresholds, auto-recharge), and Stripe integration (arrears invoicing, tax providers, line item limits). Use when building, modifying, or reviewing any Metronome integration — including ingesting usage events, creating customers, contracts, or rate cards, designing billable metric group keys, managing credits and commits, configuring invoicing, syncing invoices with Stripe Billing, billing AI applications for token usage, setting up self-serve (PLG) pricing, reviewing customer health, commit burn, portfolios, or renewals, or migrating from Stripe Billing Meters to Metronome.

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MongoDB schema design patterns and anti-patterns. Use when designing data models, reviewing schemas, migrating from SQL, or troubleshooting performance issues caused by schema problems. Triggers on "design schema", "embed vs reference", "MongoDB data model", "schema review", "unbounded arrays", "one-to-many", "tree structure", "16MB limit", "schema validation", "JSON Schema", "time series", "schema migration", "polymorphic", "TTL", "data lifecycle", "archive", "index explosion", "unnecessary indexes", "approximation pattern", "document versioning".

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Integrate antennas into RF systems using MATLAB Antenna Toolbox and RF Toolbox. Covers impedance matching network design (L/Pi/Tee topologies, evaluation parameters, Richards transformation), measured antenna creation (E-field, directivity-only, EmbeddedE, ffsReader import), RF propagation and site planning (txsite/rxsite, coverage, SINR, ray tracing, link budget), and SAR estimation (birdcage+Phantom, conformalArray+Custom3D, direct EHfields). Use when the user wants to match an antenna, create a measuredAntenna, compute coverage or signal strength, perform ray tracing, or estimate SAR.

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Read BEFORE writing any code that builds or simulates OFDM systems. The default MATLAB patterns for OFDM (e.g., direct ifft/fft, awgn with 0 dBW power, missing symOffset) produce subtly incorrect results — always use ofdmmod/ofdmdemod instead of direct IFFT/FFT. This skill specifies the correct calling conventions for ofdmmod, ofdmdemod, ofdmChannelResponse, ofdmEqualize, and critical anti-patterns that must be avoided. Use when building OFDM transmitters or receivers, allocating subcarriers and guard bands, inserting pilots, computing SNR for OFDM, configuring fading channels (Rayleigh/Rician), estimating and equalizing channels, implementing timing and frequency synchronization, adding LDPC coding, designing resource grids, or setting up OFDM link simulations.

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Extract features from 1D signals using signalTimeFeatureExtractor, signalFrequencyFeatureExtractor, and signalTimeFrequencyFeatureExtractor. Use when computing time-domain features (amplitude, energy, shape factors), frequency-domain features (spectral location, power, bandwidth, PSD), or time-frequency features (spectral shape, instantaneous, ridges, wavelet, EMD-derived) on a per-frame basis. Use when the user asks to "extract features", "compute spectral features", "build a feature table for a classifier", "get per-frame statistics", "run feature extraction on this signal", or describes a vibration / biosignal / radar / sensor signal needing features for downstream ML or analysis. Includes optional GPU acceleration via canUseGPU and gpuArray. Does not cover filter design, audio-specific feature extraction (use audioFeatureExtractor in Audio Toolbox instead), batch dataset orchestration, or 2D / image features.

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Read BEFORE writing any code that adds Additive White Gaussian Noise (AWGN) to signals and converts between SNR, Eb/No, Es/No, and per-subcarrier SNR for communications simulations, using awgn(), convertSNR(), berawgn(). The default MATLAB patterns for AWGN (e.g., 'measured' option, manual SNR formulas) produce subtly incorrect results. This skill specifies the correct calling conventions, required function usage, and critical anti-patterns that must be avoided.

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Generate 3GPP-compliant 5G NR downlink and uplink baseband waveforms. Use to create NR signals, test model (TM) waveforms, fixed reference channels (FRC), test and measurement (T&M) signals, or test vectors for conformance testing. Covers configuring data, control, and broadcast channels and signals: PDSCH, PUSCH, PDCCH, PUCCH, SRS, SSBurst, CSI-RS, DM-RS, PT-RS, CORESET, and BWP parameters including bandwidth, subcarrier spacing (SCS), modulation (QPSK, QAM), numerology, FR1, FR2, TDD, FDD, and multi-bandwidth-part setups. Use for signal generation, RF instrument playback, or IQ baseband synthesis. Requires 5G Toolbox.

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Cascade PCB components, add lumped elements, export Touchstone, and bridge to eye diagram or antenna array workflows. TRIGGER: user asks to cascade or connect multiple RF PCB components, add lumped R/L/C, export S-parameters to Touchstone, or combine PCB elements into a circuit. Invoke BEFORE writing pcbcascade or circuit code — cascade rules and port matching are non-obvious. SKIP: designing individual components (use the specific matlab-design-pcb-* skill), EM analysis of a single component (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material), optimization (use matlab-optimize-pcb-design).

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Translate NI-DAQmx C function signatures into correct calldaqlib MATLAB calls. Use when the user mentions calldaqlib, any DAQmx* C function name (DAQmxCfgSampClkTiming, DAQmxExportSignal, DAQmxSetStartTrigRetriggerable, DAQmxGetSampClkRate, etc.), or needs NI-DAQmx functionality not exposed by the daq object. Covers: projection rules (taskHandle implicit, output pointers become return values, buffer-size args, enum-as-string), multi-task semantics, start() clobber, device-level empty-daq workaround, dictionary returns, string getter placeholder, array getter placeholder. Trigger contexts: low-level DAQ, escape hatch, retriggerable acquisition, shared timebase, export signal, connect terminals, external sample clock, trigger configuration, NI driver, C function translation.

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Computes multi-constellation Global Positioning System (GPS) or Global Navigation Satellite System (GNSS) positions from RINEX v3 data using rinexread, gnssmeasurements, receiverposition, and gnssoptions. Filters by constellation, elevation mask, C/N0, and observation code. Reports DOP, scatter RMS, and satellite count. Use when processing GNSS data, computing positions from RINEX files, analyzing accuracy, comparing constellations, or evaluating satellite geometry. Do NOT use for carrier-phase RTK/PPP, IMU fusion, orbit propagation, NMEA streaming, or RINEX v4.

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Design, select, and analyze waveforms for radar, sonar, and active sensing using the Phased Array System Toolbox. Covers LFM, NLFM, FMCW, phase-coded, CW, stepped FM, custom IQ, ambiguity functions, sidelobe reduction, and Doppler tolerance. Key objects: phased.LinearFMWaveform, phased.NonlinearFMWaveform, phased.CustomFMWaveform, phased.PhaseCodedWaveform, phased.FMCWWaveform, phased.SteppedFMWaveform, phased.MFSKWaveform, phased.RectangularWaveform, nlfmspec2freq, shapespectrum, ambgfun, pambgfun, sidelobelevel, legendreseq, mlseq, radarWaveformGenerator.

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Create and customize MATLAB charts and plots. Plot types (line, scatter, bar, histogram, heatmap, surface), axes configuration, annotations, data tips, interactive plots, animation, multiple axes with tiledlayout, colororder, and performance optimization. Works for standalone figures, Live Scripts, and uifigure apps. Use when plotting data, customizing axes, adding annotations or interactivity, animating charts, or arranging multiple axes. Triggers: plot, chart, graph, axes, uiaxes, annotation, data tips, animation, tiledlayout, colororder, heatmap, scatter, figure, visualization, export.

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Import raw data (CSV, XLSX, TXT, or MATLAB tables) into formats used by Sensor Fusion and Tracking Toolbox. Handles both ground truth trajectories and sensor detection data. For truth: builds trackingScenarioRecording, tuning timetable, truthlog, or converted table. For sensor data: builds task-oriented dataFormat structs (preferred) or objectDetection arrays (legacy). Use when importing flight logs, GPS logs, radar detections, IR measurements, lidar/camera bounding boxes, ADS-B data, AIS ship tracks, or any recorded data for use with trackers, filter tuning, or tracker evaluation.

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Analyze data using MATLAB. Use when the task involves tables, timetables, time-series data, numeric arrays, sensor matrices, or gridded data — including but not limited to exploring, row filtering, sorting, cleaning, transforming, aggregating, smoothing, padding, trimming, and answering questions about data. MATLAB provides extensive, easy-to-use built-in functions for these workflows with no additional products required.

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RoadRunner asset path lookup tables for map format conversions in MATLAB. Maps lane markings, signs, signals, barriers, objects, and lane types to RoadRunner asset paths. Use when converting map formats to RRHD, resolving asset paths, or assigning visual assets to HD Map objects.

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Build RoadRunner HD Map entities in MATLAB — lanes, boundaries, markings, junctions, signs, signals, barriers, parking. Use when creating driving scenes from scratch, authoring road networks for simulation and testing automated driving systems, or assembling RRHD maps from Lanelet2 or other HD map sources.

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TikTok Shop shipping setup — carrier selection, shipping templates, delivery expectations

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Compare and optimize shipping rates across carriers and fulfillment methods. UPS, FedEx, USPS, DHL rate comparison, zone optimization, and shipping strategy to maximize margins.

日本語の概要は準備中です。原文の説明を表示しています。