Train and deploy neural networks in distributed E2B sandboxes with Flow Nexus
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概要と使いどころ
Train and deploy neural networks in distributed E2B sandboxes with Flow Nexus
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Digital pathology image processing toolkit for whole slide images (WSI). Use this skill when working with histopathology slides, processing H&E or IHC stained tissue images, extracting tiles from gigapixel pathology images, detecting tissue regions, segmenting tissue masks, or preparing datasets for computational pathology deep learning pipelines. Applies to WSI formats (SVS, TIFF, NDPI), tile-based analysis, and histological image preprocessing workflows.
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NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.
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Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.
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Use when invalid data causes failures deep in execution, requiring validation at multiple system layers - validates at every layer data passes through to make bugs structurally impossible
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Use when pentesting an Android/iOS app — Frida 17 instrumentation, SSL-pinning & root/jailbreak bypass, Android 14/15 CA injection, exported-component/content-provider abuse, deep-link/WebView chains, biometric bypass, Flutter/React-Native RE
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Run an extremely strict maintainability review for abstraction quality, giant files, and spaghetti-condition growth. Use for a thermo-nuclear code quality review, thermonuclear review, deep code quality audit, or especially harsh maintainability review.
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TypeScript and JavaScript expert with deep knowledge of type-level programming, performance optimization, monorepo management, migration strategies, and modern tooling. Use PROACTIVELY for any TypeScript/JavaScript issues including complex type gymnastics, build performance, debugging, and architectural decisions. If a specialized expert is a better fit, I will recommend switching and stop.
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Scan a codebase for deepening opportunities, present them as a visual HTML report, then grill through whichever one you pick.
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GATK Best Practices for germline SNP/indel calling from WGS/WES BAMs. Per-sample HaplotypeCaller GVCFs, GenomicsDBImport, GenotypeGVCFs joint calling, VQSR or hard filters. Requires BWA-MEM2-aligned, markdup, BQSR BAMs. Use DeepVariant for a faster DL alternative; GATK is the NIH/ENCODE standard.
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Genomic interval ops on BED/BAM/GFF/VCF. Find overlaps, merge intervals, compute coverage, extract FASTA, find nearest features. Core for ChIP-seq peak annotation, region filtering, genome arithmetic. Use tabix for indexed single-region queries; use deeptools for normalized bigWig coverage.
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NGS CLI for ChIP/RNA/ATAC-seq. BAM→bigWig with RPGC/CPM/RPKM, sample correlation/PCA, heatmaps/profiles around features, fingerprints. For alignment use STAR/BWA; for peak calling use MACS2.
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Detect somatic CNVs from WES/WGS/targeted BAMs (CNVkit v0.9.x). Bin coverage in target/antitarget regions, normalize vs reference, segment with CBS/HMM, call amps/dels, scatter/diagram plots, purity/ploidy, VCF/SEG export. CLI plus Python API (cnvlib). Use GATK CNV for deep WGS with population controls; use CNVkit for targeted/exome where antitarget bins matter.
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Unified Python interface to 40+ bioinformatics web services: UniProt proteins, KEGG pathways, ChEMBL/ChEBI/PubChem, BLAST, cross-database ID mapping, GO annotations, PPI. For deep single-DB queries use dedicated tools (gget for Ensembl, pubchempy for PubChem); bioservices excels at cross-database workflows.
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CLI toolkit for SAM/BAM/CRAM: sort, index, convert, filter, QC alignments. Core commands: view, sort, index, flagstat, stats, depth, markdup, merge. Required between alignment and variant/peak calling. Use pysam for Python-native BAM access; deeptools for normalized coverage tracks.
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Read/write SAM/BAM/CRAM, VCF/BCF, FASTA/FASTQ. Region queries, pileup, variant filtering, read groups. Python htslib wrapper exposing samtools/bcftools CLI. Use STAR/BWA for alignment; GATK/DeepVariant for variant calling.
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Classical ML in Python: classification, regression, clustering, dim reduction, evaluation, tuning, preprocessing pipelines. Linear models, tree ensembles, SVMs, K-Means, PCA, t-SNE. Use PyTorch/TF for deep learning; XGBoost/LightGBM for scale.
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Operational knowledge for the daily-brief digest pipeline (this project). RSS/API fetchers, pluggable LLM enrichment (default claude CLI on Max; also anthropic/openai/deepseek/minimax API), trading section, HTML rendering, cross-platform scheduler integration (Windows Task Scheduler / macOS launchd / Linux cron). Load when the user asks about running daily / regenerating sections / debugging a failed run / adding or disabling sources / LLM quota / scheduler / why a tab shows wrong data / why a source failed / switching LLM backend. Always prefer the documented npm commands over re-implementing logic. Diagnose by reading logs/daily-*.log first, then logs/llm-calls.jsonl for LLM-side issues.
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When the user wants to deeply understand their ideal customer before writing copy — pains, desires, inner monologue, and language. Also use when the user mentions "empathy engine", "know your target", "customer pain points", or asks to research their audience before writing Blitz Copy.
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Remove the discourse-level (structural) signs of AI writing that survive surface editing: stated lessons and moral-of-the-story closers, tidy single-track arcs, embodied-emotion performance ("chest tightened"), vague allusions instead of named references, unbroken linear structure, and shape convergence across pieces. Grounded in the StoryScope study (Russell et al. 2026): narrative structure alone detects AI text at 93.2% F1, and professional stylistic rewriting moved detection only 1.6 points. Use as the SECOND pass after the humanizer skill (which handles words and phrasing) whenever writing or revising LinkedIn posts, course lessons, blog posts, essays, newsletters, or emails that must read as human. Triggers: "humanize", "de-slop", "AI tells", "make this sound human", "structural pass", "deep humanize".
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Provides Gemini CLI delegation workflows for large-context analysis and complex reasoning using Gemini 3.0 Flash and Gemini 3.0 Pro models, including English prompt formulation, execution flags, and safe result handling. Use when the user explicitly asks to use Gemini for tasks such as broad codebase analysis, fast iterations with Gemini 3 Flash, or deep architectural reasoning with Gemini 3 Pro. Triggers on "use gemini", "delegate to gemini", "run gemini cli", "ask gemini", "use gemini for this task", "use gemini 3 flash", "use gemini 3 pro".
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Use when planning to rank for a specific keyword. The agent Googles it, reads the top 10, classifies intent, reads the top 3 competitor pages, and produces a 90-day ranking plan with intent, SERP analysis, and content recommendations.
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Automate construction data processing using LLM (ChatGPT, Claude, LLaMA). Generate Python/Pandas scripts, extract data from documents, and create automated pipelines without deep programming knowledge.
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Train ML models on Databricks. Use for: classification/regression/deep-learning (XGBoost, scikit-learn, LightGBM, PyTorch) with Optuna, @prod/@challenger aliases, batch scoring (spark_udf for plain models, fe.score_batch for feature-store-backed), custom PyFunc, custom ResponsesAgent (LangGraph + UC Function/Vector Search); UC feature tables + FeatureLookup + point-in-time joins + Lakebase online store; declarative Feature Views (create_feature, DeltaTableSource, RollingWindow/SlidingWindow/TumblingWindow, materialize_features, streaming Kafka features). NOT for: endpoint ops (databricks-model-serving), MLflow evaluation (databricks-mlflow-evaluation).
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