1.5万 件 ・ 関連度順
概要と使いどころ
Database access patterns for performance. Separate read/write models, avoid N+1 queries, use AsNoTracking, apply row limits, and never do application-side joins. Works with EF Core and Dapper.
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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.
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Performs differential expression on bulk RNA-seq count data with DESeq2's negative-binomial GLM, Wald and LRT testing, apeglm/ashr/normal LFC shrinkage, independent filtering, Cook's outlier handling, VST/rlog transforms, and design formulas including paired, batch, and interaction terms. Use when running bulk DE, choosing DESeq2 over edgeR or limma-voom, building a paired or interaction design, applying LFC shrinkage for ranking or GSEA, choosing Wald vs LRT, troubleshooting padj=NA, picking VST vs rlog, importing salmon/kallisto via tximport, or analyzing prokaryotic RNA-seq.
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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Installs 425 bioinformatics skills covering sequence analysis, RNA-seq, single-cell, variant calling, metagenomics, structural biology, and 56 more categories. Use when setting up bioinformatics capabilities or when a bioinformatics task requires specialized skills not yet installed.
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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.
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Use when an Apple-platform app feels slow, memory grows, battery drains, or ANY performance issue needs diagnosing. Covers memory leaks, profiling, Instruments workflows, retain cycles, optimization.
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Use when the user mentions SwiftUI performance, janky scrolling, slow animations, or view update issues — expensive bodies, formatters, whole-collection dependencies, and missing lazy containers.
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Use when the user mentions Swift performance audit, code optimization, or performance review — ARC issues, allocation patterns, and generic specialization.
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Apply modern Swift language patterns and idioms for non-concurrency, non-SwiftUI code. Covers if/switch expressions (Swift 5.9+), typed throws (Swift 6+), result builders, property wrappers, opaque and existential types (some vs any), guard patterns, Never type, Regex builders (Swift 5.7+), basic Codable shaping (CodingKeys, custom decoding, nested containers), modern collection APIs (count(where:), contains(where:), replacing()), basic FormatStyle usage, and string interpolation patterns. Use when writing core Swift code involving generics, protocols, enums, closures, or modern language features; route deep Codable to swift-codable, detailed formatting/localization to swift-formatstyle, and API naming to swift-api-design-guidelines.
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Audit, diagnose, or optimize website loading and interaction performance, Core Web Vitals, and Lighthouse performance scores.
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Use this skill when the user asks what information a Stripe Connect connected account must provide for verification, onboarding, KYC, or account requirements; when they need to compare requirements between connected-account setups; or when they ask which verification fields, documents, or business details are required for a particular platform country, account country, business type, dashboard, service agreement, or capability.
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Use this skill when the user asks about Stripe Connect configuration, charge patterns, Dashboard access, or how to get started with Connect, is building a marketplace, platform, multi-vendor store, gig platform, or subscription platform, needs to pay out sellers, vendors, or providers, mentions split payments, revenue sharing, multi-party payments, or similar payment distribution concepts, provides a company URL or business description for a recommendation, builds SaaS that routes money between parties (for example, POS, booking, invoicing — not operational SaaS without payment routing), asks about onboarding or KYC for merchants, sellers, and vendors, mentions connected account Dashboard or responsibility configurations, or asks about payment flows, white-label payments, or embedded payments.
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React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.
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Transmit and capture RF waveforms using Wireless Testbench with NI USRP radios (X410, X310, N310, N320, N321, N300, X300, E320). Use when generating test signals, transmitting over the air, capturing IQ data, performing loopback tests, configuring multi-antenna setups, or troubleshooting dropped samples and gain settings. Covers basebandTransceiver, basebandTransmitter, basebandReceiver, continuous and once transmit modes, foreground and background capture, and UseRadioBuffer options. Also use when the user mentions transmit waveform, capture signal, IQ data, loopback, RF gain, sample rate, or antenna configuration.
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Integrate antennas into RF systems using MATLAB Antenna Toolbox and RF Toolbox. Covers impedance matching network design (L/Pi/Tee topologies, evaluation parameters, Richards transformation), measured antenna creation (E-field, directivity-only, EmbeddedE, ffsReader import), RF propagation and site planning (txsite/rxsite, coverage, SINR, ray tracing, link budget), and SAR estimation (birdcage+Phantom, conformalArray+Custom3D, direct EHfields). Use when the user wants to match an antenna, create a measuredAntenna, compute coverage or signal strength, perform ray tracing, or estimate SAR.
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Speed up local parfor, parfeval, or spmd by switching to a thread-based parallel pool. Trigger when a user describes slow or disappointing local parallel performance, even if they don't mention threads. Symptoms: parfor on a laptop/workstation is slower than expected or "only slightly faster than for"; parfor scales poorly with the number of workers; ticBytes/tocBytes, the Parallel Pool dashboard, mpiprofile, or system tools show large per-worker data transfer; large broadcast variables or sliced inputs make iterations slow; opening a process pool dominates a short workload; user mentions serialisation or data transfer overhead. Also trigger on any question about whether code or a function works on a thread pool. For non-pool MATLAB performance work (vectorisation, preallocation, profiling), defer to matlab-optimize-performance.
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Writes MATLAB performance tests using the matlab.perftest.TestCase framework. Use when asked to write, create, or add performance tests for MATLAB code, benchmark functions, measure execution time with statistical rigor, or use runperf.
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Analyze AMS waveform data using Mixed-Signal Blockset utilities: phase noise measurement, clock jitter, anti-aliased resampling, timing measurements, lock time, INL/DNL, ADC/DAC calibration, HSpice import. Use when analyzing time-domain voltage from PLL/VCO/clock simulations, measuring phase noise from variable-step solver output, computing jitter, or resampling non-uniform data.
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Perform aerospace unit conversions, time conversions, coordinate frame transformations, and rotation representations using Aerospace Toolbox. Use when converting units (length, velocity, angle, acceleration, angular velocity, force, mass, pressure, temperature, density), computing Julian dates or decimal years, transforming between coordinate frames (ECEF, ECI, LLA, flat Earth, geodetic/geocentric, NED, body, wind, stability), or working with rotation representations (Euler angles, DCM, quaternion, Rodrigues vector). Also use when the user asks about aerospace coordinate systems, reference frames, or rotation conventions.
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Read and write 3-D point cloud data using Lidar Toolbox file I/O. Covers PLY, PCD, LAS/LAZ, PCAP (Velodyne/Ouster/Hesai), E57, and IDC (Ibeo) formats. Use when loading point clouds from disk, saving to disk, choosing the correct reader or writer for a file format, extracting or preserving lidar point attributes, reading Ibeo IDC sensor recordings, or converting between formats.
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Load this first for any task involving images, pictures, photos, scans, frames, volumes, or visual data — including reading, writing, filtering, enhancing, denoising, sharpening, deblurring, thresholding, segmenting, masking, detecting, finding or counting objects, removing backgrounds, measuring, comparing, registering, stitching, aligning, cropping, resizing, transforming, or analyzing. Use for image I/O (TIFF, PNG, JPEG, RAW, HDR), histograms, edge detection, color processing, morphology, geometric transforms, deep learning for images, quality assessment, and 3-D volume processing. Also triggers when users describe image problems (dark, noisy, blurry, low contrast, uneven lighting, hazy, color cast) or data exploration tasks (folder of images, characterize data, understand format). Handles microscopy (cells, particles) and general scientific imaging. Routes to sibling skills for medical imaging (DICOM, NIfTI), hyperspectral data, and visual inspection.
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Track and analyze e-commerce sales performance across platforms. Set up KPI dashboards, trend analysis, and performance alerts to catch issues and opportunities early.
日本語の概要は準備中です。原文の説明を表示しています。