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概要と使いどころ
Rebuild the DSH node's persistent knowledge state. Runs register-claude.py to (re)create the dome.db schema and upsert agents/skills/tools/stack rows, then runs ingest.py to re-index kb/, logs/, docs, and agent core source into ChromaDB's dome-kb collection, then runs pre-spore-verify.py to confirm all 7 skill modules load and the akashic write+query roundtrip works. Idempotent — safe to run any time.
日本語の概要は準備中です。原文の説明を表示しています。
Reflective pass over your memory files — merge duplicates, fix stale facts, prune the index.
日本語の概要は準備中です。原文の説明を表示しています。
Database optimization, query tuning, indexing strategies, migration management, and performance monitoring for PostgreSQL with Drizzle ORM. Use when optimizing slow queries, designing schemas, creating migrations, or setting up database monitoring.
日本語の概要は準備中です。原文の説明を表示しています。
Search, create, and manage notes in the Obsidian vault with wikilinks and index notes. Use when user wants to find, create, or organize notes in Obsidian.
日本語の概要は準備中です。原文の説明を表示しています。
Design database schemas — tables, relationships, indexes, constraints, and ORM setup. Covers relational design, normalization, and common patterns.
日本語の概要は準備中です。原文の説明を表示しています。
Builds and validates predictive time-to-event models on clinical and omics data with penalized Cox, random survival forests, gradient-boosted and deep survival models, and prediction-grade evaluation (Uno's C, time-dependent AUC, integrated Brier, calibration, competing risks). Use when building an individualized risk predictor or prognostic omics signature, choosing a survival model, or evaluating one beyond the C-index. For Kaplan-Meier, log-rank, and classical Cox hazard-ratio inference in a trial see clinical-biostatistics/survival-analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Facebook's library for efficient similarity search and clustering of dense vectors. Supports billions of vectors, GPU acceleration, and various index types (Flat, IVF, HNSW). Use for fast k-NN search, large-scale vector retrieval, or when you need pure similarity search without metadata. Best for high-performance applications.
日本語の概要は準備中です。原文の説明を表示しています。
This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
日本語の概要は準備中です。原文の説明を表示しています。
Authors portable, strongly-typed bioinformatics pipelines in the Common Workflow Language (CWL v1.2) as CommandLineTool/Workflow/ExpressionTool documents, validated with cwltool and run at scale on Toil/Arvados/Calrissian. Use when deciding CWL (portability/provenance/regulated) vs Nextflow/WDL/Snakemake; declaring secondaryFiles for indexed companions (.bai/.fai/.dict/.tbi and the caret rule); putting resources/containers under requirements (must-hold) vs hints (advisory) to avoid silent OOM; choosing scatterMethod (dotproduct vs flat_/nested_crossproduct); preferring $(...) parameter refs over ${...} JavaScript for portability; pinning DockerRequirement images; or emitting a CWLProv provenance object for audited/clinical settings.
日本語の概要は準備中です。原文の説明を表示しています。
Drug-combination synergy analysis — quantify whether two drugs together are synergistic, additive, or antagonistic using the standard reference models (Bliss independence, HSA / highest single agent, Loewe additivity, ZIP, and the Chou-Talalay Combination Index). Use when you have measured single-drug and combination effects (inhibition/viability) and need a synergy score. Explains which model to use, what data each one needs, and how to read the score. NOT for looking up pre-computed synergy in a database (use the SYNERGxDB tool / cell-line-profiling skill).
日本語の概要は準備中です。原文の説明を表示しています。
Querying Stellar chain data via Stellar RPC (preferred) and Horizon (legacy). Covers RPC JSON-RPC methods, Horizon REST endpoints, streaming, pagination, historical queries, Hubble/Galexie for deep history, and the RPC/Horizon migration story. Use when reading balances, transactions, operations, ledgers, contract events, or building any indexer/analytics workflow.
日本語の概要は準備中です。原文の説明を表示しています。
Answers "can CARLA do X here, and is there a vetted procedure for it" before you promise anything, and detects client/server/tree version skew — a support matrix over the whole collection (covered by a skill / works but undocumented / present but untested / broken or removed), an index of the features that are verified BROKEN on 0.10.0 (gbuffers crash the server, map layers do nothing, Landmark.waypoint is None, standalone asset packages are gone), and a probe that reports what this machine's build flags and running server actually offer. Use when the user asks whether CARLA supports something, when a feature has no skill, when a UE4 tutorial's steps do not exist, or before improvising a procedure.
日本語の概要は準備中です。原文の説明を表示しています。
Audit and improve website readiness for AI agents using the Cloudflare "Is It Agent Ready?" scanner (isitagentready.com). Covers scanning via API, interpreting results, generating implementation prompts, and fixing every check. Use when the user mentions "agent ready", "isitagentready", "AI agent scan", "agent readiness", "agent-ready score", "MCP server card", "agent skills index", "markdown for agents", "content signals", "web bot auth", "agent discovery", "RFC 9727", "RFC 8288", "RFC 9728", "SEP-1649", "WebMCP", "x402", "UCP", "ACP", or wants to make a website discoverable and usable by AI agents.
日本語の概要は準備中です。原文の説明を表示しています。
Creates, debugs, and optimizes GitHub Actions workflow YAML files. Recommends current action versions with SHA pinning from a daily-updated index of 120+ actions. Configures matrix builds, dependency caching, reusable workflows, OIDC authentication, secrets management, and runner selection. Reviews existing workflows for outdated actions, security issues, and performance problems. Use when the user asks about GitHub Actions, workflows, CI/CD, .github/workflows, any action by name (actions/checkout, setup-node, setup-python, etc.), or workflow optimization.
日本語の概要は準備中です。原文の説明を表示しています。
Use when working with access policies, field access, authorization middleware, gates, route access control, AccessResult semantics, permission handlers, or files in packages/access/, packages/routing/src/AccessChecker.php, packages/user/src/Middleware/. Covers entity-level access (deny-by-default via isAllowed), field-level access (open-by-default via !isForbidden), the Gate system, route options (_public, _permission, _role, _gate), and the SessionMiddleware/AuthorizationMiddleware pipeline in public/index.php.
日本語の概要は準備中です。原文の説明を表示しています。
Technical SEO audit across 8 categories: crawlability, indexability, security, URL structure, mobile, Core Web Vitals, structured data, JS rendering. Schema deep validation → seo-schema. AI crawlers → seo-geo-technical. Use when user says "technical SEO", "crawl issues", "robots.txt", "Core Web Vitals".
日本語の概要は準備中です。原文の説明を表示しています。
Create or update a pull request for the current branch. Trigger when the user asks to create/open/make a PR, or to edit/update/rewrite/fix the PR description, body, or summary — for both new PRs (`gh pr create`) and existing ones (`gh pr edit --body-file`). Use for any verb that lands on a PR's text content: "open a PR", "make a PR", "update the PR description", "rewrite the PR body", "fix the description".
日本語の概要は準備中です。原文の説明を表示しています。
Use whenever SQL, ORM/jOOQ code, schema or migrations, indexes, N+1, or database load are in play, even without the word "review" — delegates the performance review of the current branch diff to the sql-performance-reviewer agent.
日本語の概要は準備中です。原文の説明を表示しています。
Ensure data model/DB designs cover constraints, integrity, indexes, migrations, rollback, and operational impacts.
日本語の概要は準備中です。原文の説明を表示しています。
Reviews Laravel migrations for destructive operations, change() dropping modifiers, locking index creation on large tables (PostgreSQL), and asymmetric down().
日本語の概要は準備中です。原文の説明を表示しています。
Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools (bedGraphToBigWig, bigWigToBedGraph, bigWigInfo, bigWigSummary, bigWigAverageOverBed) and deepTools (multiBigwigSummary, computeMatrix, bigwigCompare). Covers the central trap that a wide query returns a precomputed zoom-level summary (by default the mean, which annihilates narrow peaks) not per-base data, when exact=True/values() is mandatory, the NaN-not-zero gap-handling fork, choosing mean vs max vs sum vs coverage by biological question, and the sorted-bedGraph plus chrom.sizes build requirement. Use when extracting signal at regions, computing mean signal per gene/peak, building a browser track from bedGraph, comparing tracks, or building TSS/gene-body metaprofiles.
日本語の概要は準備中です。原文の説明を表示しています。
Detects m6A modifications from Oxford Nanopore direct-RNA-sequencing (ONT DRS) signal data using m6Anet (Hendra 2022 *Nat Methods* 19:1590; multiple-instance-learning neural network over DRACH 5-mer signal). Covers the required upstream pipeline (Dorado / Guppy basecalling -> minimap2 transcriptome alignment with `-ax map-ont -uf -k14 --secondary=no` -> nanopolish eventalign with `--scale-events --signal-index` (m6Anet-required) plus `--summary` / `--threads` housekeeping -> m6anet dataprep -> m6anet inference), per-site vs per-read probability interpretation including the `mod_ratio` per-site stoichiometry column, the DRACH-only modeling constraint, minimum-coverage thresholds (20-50 reads per site for stable probability estimates), multi-condition comparison via xPore (Pratanwanich 2021 *Nat Biotechnol* 39:1394), Nanocompore (Leger 2021 *Nat Commun* 12:7198), ELIGOS (Jenjaroenpun 2021 *NAR* 49:e7), and Dorado native modification calling (RNA004 chemistry, 2024+), reference-transcriptome version pinning, the cDNA-vs-DRS chemistry distinction (cDNA-Nanopore CANNOT be used for modification detection), and orthogonal validation against MeRIP / GLORI. Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting per-site `probability_modified` vs `mod_ratio` vs per-read modification probabilities, comparing methylation between conditions from ONT data, deciding between m6Anet for known DRACH sites and Dorado/Remora for genome-wide screening, pinning RNA002 vs RNA004 chemistry and basecaller model versions, or troubleshooting eventalign / dataprep failures.
日本語の概要は準備中です。原文の説明を表示しています。
Aligns and QCs methylated-RNA-immunoprecipitation (MeRIP / m6A-seq) IP and input libraries using STAR or HISAT2 splice-aware mapping, samtools sort/index, IP/input matched-pair tracking, antibody-lot metadata recording, replicate concordance via deepTools multiBamSummary + plotCorrelation, IP enrichment QC via plotFingerprint and per-transcript IP/input ratio distributions, library-complexity saturation curves via PreSeq c_curve / lc_extrap, and the explicit do-NOT-deduplicate convention for standard non-UMI MeRIP. Use when preparing paired IP and input BAM files for exomePeak2 / MeTPeak / MACS3 peak calling, evaluating MeRIP replicate concordance and IP enrichment, deciding whether to deduplicate (standard MeRIP typically NOT — see Tips), choosing genome-vs-transcriptome alignment for downstream peak vs m6Anet workflows, recording antibody clone and lot metadata for downstream cross-batch reconciliation, detecting failed IPs via saturation curves and IP/input distribution shape, or generating IP-over-Input bigWig tracks for downstream visualisation.
日本語の概要は準備中です。原文の説明を表示しています。
Processes eDNA metabarcoding from raw paired-end reads to species tables, navigating ASV (DADA2, UNOISE3) vs OTU (swarm v2) decision (Callahan 2017 vs Schloss multi-copy-16S critique), marker/primer choice (Leray COI, MiFish 12S, 515F/806R 16S, ITS2) with primer-specific bias, OBITools3 v3 command-name break (obi stats plural; .tar.gz taxonomy), tag-jumping with dual-indexing (Schnell 2015; NovaSeq 10x MiSeq), decontam as screening-not-classifier (Davis 2018), read-counts-not-abundance critique (Lamb 2019), site-occupancy modeling (Ficetola 2015), Naive-Bayes calibration limits (Bokulich 2018), and eDNA decay (Strickler 2015). Use when going from raw eDNA FASTQ to species tables, picking marker + denoising pipeline, deciding whether read counts represent abundance, applying occupancy modeling, configuring OBITools3 v3, or interpreting decontam output. Not for clinical 16S microbiome (see microbiome/amplicon-processing).
日本語の概要は準備中です。原文の説明を表示しています。