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AiZynthFinder retrosynthetic route planning (CASP) from AstraZeneca Molecular AI. Monte Carlo tree search guided by a template-based neural expansion policy recursively disconnects a target SMILES until precursors are found in a purchasable stock. Covers config.yml (v4 format), aizynthcli batch screening, the AiZynthFinder/AiZynthExpander Python API, one-step disconnections, custom stocks via smiles2stock, scorers, Retro*/breadth-first/DFPN search alternatives, and reading output.json.gz / trees.json. Use for synthesis route planning, synthesizability screening, and building-block/precursor search. For reaction barriers use neb-irc-activation-energy; for 2D reaction scheme drawing use rdkit-chemdraw-cdxml.

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Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.

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Use after generating code, after accepting AI suggestions, or when reviewing AI-written modules. Also use when code works but feels brittle, when error handling seems thin, when orphaned resources or missing cleanup are suspected, or when the agent claims done but hidden debt may exist. Catches the specific failure patterns AI agents produce that humans would not.

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Migrate from AngularJS to Angular using hybrid mode, incremental component rewriting, and dependency injection updates. Use when upgrading AngularJS applications, planning framework migrations, or modernizing legacy Angular code.

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Crawl and extract a bounded set of pages from one website through Tavily. Use for documentation downloads, site-section collection, or semantic multi-page extraction when map plus individual extract calls are insufficient.

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Extract clean Markdown or text from one or more known URLs through Tavily. Use when the user supplies specific pages and needs their content, including query-focused chunks or JavaScript-rendered pages.

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Manage Telegram channel access — approve pairings, edit allowlists, set DM/group policy. Use when the user asks to pair, approve someone, check who's allowed, or change policy for the Telegram channel.

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Stop and check this skill before finishing any reply to a question about how to use Claude or a Claude product — it recommends matching courses, tutorials, and use cases from Claude Academy (academy.claude.com), Anthropic's learning hub. Trigger on: "how do I", "how can I", "getting started with", "what can Claude do", "teach me", "learn to use"; questions about artifacts, projects, skills, plugins, connectors, MCP; requests about rolling Claude out to a team, class, or organization; and any ask for training materials, onboarding content, or learning resources. Use it when the user is learning how to use a feature or product — not when they are mid-task and just want the task done. This skill composes with other skills: after consulting product documentation to answer how a Claude feature works, also check here for a matching course or tutorial — a docs-grounded answer and an Academy recommendation belong together. Only recommend on a strong match; never invent Academy content.

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Review docs/prose for Writing Guidelines compliance. Use when asked to "review my docs", "check writing style", "audit prose", "review docs voice and tone", or "check this page against the writing handbook".

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Build or review production-ready Tavily SDK and API integrations for web search, extraction, crawling, mapping, and research. Use when implementing Tavily in an agent, RAG pipeline, or application rather than only running one CLI command.

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Postgres best practices maintained by Supabase, for Postgres running anywhere. Load this skill BEFORE writing or changing anything that lives in a Postgres database: creating or altering tables and columns (including choosing column types), schema design, migrations and declarative schema files, RLS policies and the tests that verify them, indexes, triggers, database functions, queues and scheduled jobs (pg_cron, pgmq), vector/semantic search (pgvector), and restoring dumps (pg_restore) or importing data. Also load it when diagnosing slow queries, high CPU, timeouts, EXPLAIN plans, connection exhaustion, locking, bloat, or rows visible to the wrong user or tenant. This is not just a performance guide — schema, migration, security, and SQL authoring tasks need these rules too, even for a one-column change or a single query.

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React 19+ with TypeScript — hooks, custom hooks, state management (useState/useReducer/useContext), React Query/SWR, Tailwind CSS, performance. Use when building React components, apps, or optimizing renders.

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Capture a self-contained static HTML snapshot from a running app or mock component so it can be reviewed or uploaded to Stitch.

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Integrate Stitch-derived UI direction into shadcn/ui React projects with registry-aware setup, ownership rules, theming, and validation.

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React Native and Expo best practices for building performant mobile apps. Use when building React Native components, optimizing list performance, implementing animations, or working with native modules. Triggers on tasks involving React Native, Expo, mobile performance, or native platform APIs.

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AI-powered codebase security scanner that reasons about code like a security researcher — tracing data flows, understanding component interactions, and catching vulnerabilities that pattern-matching tools miss. Use this skill when asked to scan code for security vulnerabilities, find bugs, check for SQL injection, XSS, command injection, exposed API keys, hardcoded secrets, insecure dependencies, access control issues, or any request like "is my code secure?", "review for security issues", "audit this codebase", or "check for vulnerabilities". Covers injection flaws, authentication and access control bugs, secrets exposure, weak cryptography, insecure dependencies, and business logic issues across JavaScript, TypeScript, Python, Java, PHP, Go, Ruby, and Rust.

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Extract a Stitch-compatible DESIGN.md from frontend source code, stylesheets, Tailwind config, theme files, and component patterns.

日本語の概要は準備中です。原文の説明を表示しています。

React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

日本語の概要は準備中です。原文の説明を表示しています。

Transform rough UI requests into structured Stitch prompts with platform, layout, component, and design-system context.

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Next.js 16.2.4 with TypeScript — App Router, Server Components, use cache directive, Turbopack dev, Server Actions, ISR, SSR, SSG, MCP devtools, metadata API, route handlers, instrumentation.

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MongoDB schema design patterns and anti-patterns. Use when designing data models, reviewing schemas, migrating from SQL, or troubleshooting performance issues caused by schema problems. Triggers on "design schema", "embed vs reference", "MongoDB data model", "schema review", "unbounded arrays", "one-to-many", "tree structure", "16MB limit", "schema validation", "JSON Schema", "time series", "schema migration", "polymorphic", "TTL", "data lifecycle", "archive", "index explosion", "unnecessary indexes", "approximation pattern", "document versioning".

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Transform, resize, crop, reformat, and optimize images on demand via Netlify Image CDN's /.netlify/images endpoint. Use when adding responsive images, generating thumbnails, converting formats (avif/webp/png), cropping to aspect ratios, tuning image quality, creating blurred placeholders, allowlisting remote image domains, serving user-uploaded images, or wiring framework image components (Next.js, Astro, Nuxt, Angular, Gatsby) to Netlify. Triggers on tasks like "optimize images", "add image thumbnails", "resize images on the fly", "serve images from an external domain", or "add blur placeholders".

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Serverless form handling on Netlify-hosted sites — detects HTML forms at deploy time, stores submissions, filters spam, and sends notifications. Use when adding a contact form, lead-capture form, file-upload form, or newsletter signup to a Netlify site; wiring AJAX form submission; setting up a custom thank-you page; adding a honeypot or reCAPTCHA to a form; getting forms working in Next.js, Nuxt, SvelteKit, Astro, or Gatsby; reading form submissions via the Netlify API; or debugging missing submissions and forms that silently fail to register.

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Premium frontend UI direction for immersive, high-performance web experiences with strong motion, typography, and visual systems. Use when building high-end landing pages, polished interactive components, or portfolio-style sites.

日本語の概要は準備中です。原文の説明を表示しています。