「by」の検索結果

Delegate implementation to Codex, grok, or cursor-agent, then review the diff, send it back to iterate, gate on the full test suite, and ship it as a PR. Use this whenever the user wants Codex, the grok 后端, or cursor-agent to write code, mentions handing off / delegating implementation to one of those backends, asks to work through a plan or spec unit-by-unit with an implementation backend doing the coding, or wants a review-and-merge loop wrapped around delegated output — and also when resuming such a loop ("keep going", "next unit", "继续下一个"). It encodes constraints that are expensive to rediscover: the implementer runs in the real environment behind backend-specific git and publication boundaries, must not be pointed at a full test suite by default, and its self-report is a claim rather than evidence. This loop expects an approved plan or an equivalently precise spec; settle an unsolved high-level goal into a plan first, using the engineering-mode skill when it is installed.

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Estimate the full development cost of an existing codebase from lines of code, architectural complexity, and team-composition overhead. Use for 'how much would this cost to build', 'what did this codebase cost', development-cost or build-cost estimates, calendar-time estimates, and Claude/AI ROI on a delivered codebase. Estimates by measured LOC and complexity, not by ticket volume.

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Drafts a U.S. ocean Bill of Lading (B/L) functioning as receipt, contract of carriage, and document of title under COGSA or Hague-Visby. Covers negotiable and straight B/Ls, cargo description, freight allocation, and core carriage clauses. Use when drafting or reviewing a bill of lading, master/house B/L, ocean shipment documentation, or title transfer. Trigger keywords: bill of lading, B/L, ocean carriage, COGSA, Hague-Visby, negotiable, straight, master bill, house bill.

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Automate recruiting and hiring workflows in Ashby -- manage candidates, jobs, applications, interviews, and notes through natural language commands.

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Automate Abyssale tasks via Rube MCP (Composio). Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Manual-only skill for minimizing total codebase size. Only activate when explicitly requested by user. Measures success by final code amount, not effort. Bias toward deletion.

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Find and list functions in a binary by name, address, regex, or byte pattern. Use as the starting point for binary analysis, to locate specific functions, or to enumerate all functions matching criteria.

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Content-addressed baseline-archive epoch partitioning. Partition baseline_archive.jsonl + the self-improving hub's baseline serving by a HASH of the full baseline-production+measurement spec — when the spec (margin_rule, fitness/margin logic version, the 4 roles' model+source, rubric/dim-set, bench, seed-pool identity) changes, the hash changes → a new epoch series (like seed-gen gen-*). Triggered by "baseline epoch", "baseline 아카이빙", "epoch partition", "spec hash", "content-addressed", "margin_rule namespace", "production logic 구분", "baseline 하위 서빙" keywords.

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Verification checklist to prevent fake success. Detects test deletion/disabling, coverage regression, lint bypass, secret exposure. Triggered by "deception", "fake" ("가짜"), "fake success", "verification" ("검증"), "checklist" ("체크리스트"), "deletion detection" ("삭제 탐지"), "regression" keywords.

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Grind through ready beads in priority order by running several issues at once, each in its own isolated git worktree managed by worktrunk (`wt`), then merging the finished branches back one at a time. Use when asked to work the beads queue in parallel, to run N issues concurrently, or when a serial grind is too slow and the ready issues are independent.

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Time-travel debugging for DAG executions. Inspect agent state at any node, replay decisions with modified inputs, compare execution traces side-by-side, and identify where reasoning diverged. Inspired by LangGraph Studio's state-editing model and Temporal's event history. Activate on "debug DAG", "replay execution", "time travel debug", "inspect node state", "what went wrong at step", "compare runs", "execution diff". NOT for live monitoring (use dag-runtime + websocket-streaming), failure analysis (use dag-ops), or general code debugging.

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Fetch a URL and return clean markdown, for arbitrary external pages (blog, RFC, GitHub issue, vendor doc) not covered by mk:docs-finder. Static-only by default; opt-in JS rendering available.

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Fetch a URL and return clean markdown. Use when the agent needs an arbitrary external page (blog, RFC, GitHub issue, vendor doc) not covered by mk:docs-finder. Triggers on URLs in chat. Static-only by default; opt-in JS rendering available.

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Use when a problem requires structured step-by-step reasoning before acting. Prevents jumping to conclusions or guessing root causes without evidence. Triggers on complex debugging, multi-step analysis, hypothesis verification, or when mk:fix invokes diagnosis phase. NOT for being stuck on approach (too many implementations, forced assumptions, innovation block) — use mk:problem-solving instead.

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Create, standardize, or update step-by-step algorithm visualizations for a given problem ID. Use when the user mentions 'visual', 'visualization', 'animate', or 'step-by-step' alongside a problem ID in /problem/:id format.

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Vehicle data through Openapi Automotive - look up cars, motorcycles, insurance and MOT status by license plate across Italy, UK, Germany, France, Spain, Portugal. Use for vehicle technical data and insurance validity checks by plate.

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Authorized testing of LLM applications, agents, chatbots, RAG systems, guardrails, and tool-using model workflows. Use for LLM mode selection, jailbreak and prompt-injection assessment, guardrail bypass review, tool misuse, tool or system prompt disclosure, data exfiltration paths, model refusal/stop detection, bypass hypotheses, and hardening guidance.

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Imports gene expression count matrices from featureCounts, HTSeq, STAR ReadsPerGene, Salmon/kallisto via tximport or tximeta, RSEM, 10X Genomics MTX/H5, AnnData H5AD, and RDS. Handles silent-miscounting traps (featureCounts -p v2.0.2 API break, STAR strandedness column choice, salmon NumReads-sum without tximport, RSEM non-integer expected_count, GENCODE _PAR_Y suffix, zero-length-transcript TPM divide-by-zero), and encodes the tximport countsFromAbundance decision tree with the "lengthScaledTPM is not TPM" warning. Use when assembling a gene-by-sample count matrix from aligner or quantifier output, importing salmon/kallisto for DESeq2 vs limma-voom, choosing strandedness column for STAR, debugging zero-count panics, or building tx2gene mapping.

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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Filter and select sequences by criteria (length, ID, GC content, N content, motifs, patterns, description) using Biopython, streaming so large files never load into RAM. Use when subsetting a FASTA/FASTQ file, removing unwanted or low-quality records, or selecting records by specific criteria. Use the paired-end-fastq skill instead whenever the input is paired R1/R2 reads.

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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.

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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the gene-independent DNA-damage / G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Verify that insulin pump supplies (provided by patient or family) will be available throughout the hospitalization to support continued pump use. Triggered by questions such as "Do we have sufficient pump supplies for the hospital stay?"

日本語の概要は準備中です。原文の説明を表示しています。