「pert」の検索結果

Expert guidance for fast fine-tuning with Unsloth - 2-5x faster training, 50-80% less memory, LoRA/QLoRA optimization

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Codified expertise for managing carrier portfolios, negotiating freight rates, tracking carrier performance, allocating freight, and maintaining strategic carrier relationships. Informed by transportation managers with 15+ years experience. Includes scorecarding frameworks, RFP processes, market intelligence, and compliance vetting. Use when managing carriers, negotiating rates, evaluating carrier performance, or building freight strategies.

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Minimalist UX/Interaction Audit Expert that deconstructs complex interactions through cognitive load and operational efficiency lenses. Use this skill when you need to perform a UX walkthrough audit on a Figma prototype or web interface, evaluating usability based on principles like fewer clicks, less UI elements, no hidden logic, and self-explanatory design.

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Use when executing and reporting the analysis/interpretation for an American Anthropologist (AA) manuscript so it survives expert anonymous review — disciplined ethnographic/qualitative inference, honest interpretation, and (for biological/archaeological work) sound quantitative analysis. Guides analysis and interpretation norms; it does not fabricate evidence or quotations.

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Use when evaluating the model and analyzing results for an Agricultural Systems (AgSy) manuscript so it survives expert systems review — independent model evaluation (observed vs. simulated, fit statistics), sensitivity and uncertainty analysis, and trade-off / scenario analysis across the system. Guides evaluation norms; it does not fabricate results or run the model.

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Use when extensions, edge cases, or applied robustness checks are missing for an American Economic Journal: Microeconomics (AEJ: Micro) manuscript — covering theory extensions (relaxed assumptions, alternative concepts, perturbations) and applied/experimental robustness. Decides which extensions earn their place; it does not prove the main result (see aejmic-theory-model).

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Use when writing the response to an Agricultural Systems (AgSy) revision decision. AgSy review is single anonymized with at least two expert systems reviewers and an editor decision, and revisions often turn on model evaluation, sensitivity/uncertainty, and trade-off framing. The response must convert each reviewer without alienating the editor. Structures the response letter; it does not fabricate new results.

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Use when deciding what characterization and experimental detail an Advanced Materials manuscript must show to prove its structure–property claim, and what belongs in the Experimental Section and Supporting Information. Partitions and stress-tests methods; does not design figures or run analysis.

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Use when revising an AAMAS paper so the interaction contribution leads the first page, the solution concept or incentive property is named, the game and agents are legible, claims are paired with proofs or multiagent experiments, the argument fits eight two-column pages plus references, and the wording stays double-blind.

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Generate Echidna/Medusa-compatible Solidity fuzz suites from Foundry or Hardhat projects. Trigger on "fizz", "generate fuzz suite", "build fuzz harness", "stateful fuzzing", "fuzzing harness", "property testing", and "invariant suite".

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Governs Event Schema Sets, the Fabric registries of event types and message payload schemas. Covers create, rename, update and delete of a definition, and listing, property reads or base64 decoding. Every Event Schema Set task belongs here. Ingestion pipelines are eventstream-cli.

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Use the skill to control and verify the code interface configuration of your model — how Simulink® model elements are represented in the generated C or C++ code. This includes — (1) specifying names, types (storage classes), and placement of variables that represent model elements (for example, making a model parameter tunable as a global extern variable); (2) specifying names, types, and placement of functions that represent model algorithms; (3) selecting the deployment type (Component, Subcomponent, or Automatic); (4) selecting the interface configuration type (data or service interface); (5) linking a shared Embedded Coder dictionary to a model; (6) creating Embedded Coder dictionary entries and setting their properties; (7) for service interface configuration — specifying service interface definitions, including sender, receiver, client, and server services. Items 1 and 2 can be set per element or as a category-wide default. Item 1 applies to GRT and ERT models; the rest to ERT models only.

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Publish .NET services as container images with the built-in SDK tooling (dotnet publish /t:PublishContainer, Microsoft.NET.Build.Containers) - no Dockerfile required. Covers the MSBuild property surface, base-image inference, self-contained and AOT implications, and CI/CD publishing.

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Write and simplify C# property-based, model-based, and executable specification tests with CsCheck. Use for generators, shrinking, stateful command sequences, Spec guards and rules, implementation conformance, or replaying generated failures.

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Guidelines for making .NET libraries and applications trimming-safe and Native AOT compatible. Covers the trimming/AOT model, the MSBuild properties that enable analysis (IsTrimmable, IsAotCompatible, PublishTrimmed, PublishAot), the trimming attributes (RequiresUnreferencedCode, RequiresDynamicCode, DynamicallyAccessedMembers, UnconditionalSuppressMessage), IL2xxx/IL3xxx warning codes, and a pattern playbook: source generators and UnsafeAccessor, generated-interception diagnostic suppressors, intentional runtime scanning boundaries, trimming-safe islands and feature switches, migration analyzers, and temporary warning-approval baselines. Use when introducing trimming/AOT support, resolving IL2xxx/IL3xxx warnings, or making reflection-heavy code trimming-safe in C# / .NET codebases. For System.Text.Json AOT scenarios, see also the serialization skill.

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Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Profiles RNA-binding protein targets without antibody or UV crosslinking using STAMP (APOBEC1-RBP fusion, C-to-U editing), scSTAMP (single-cell), TRIBE/HyperTRIBE (ADAR-RBP, A-to-I editing), DART-seq (APOBEC1-YTH for m6A), or Bullseye/SAILOR edit-site detection pipelines. Use when antibody is unavailable or specificity is doubtful, when single-cell RBP profiling is needed (scSTAMP), or when in vivo RBP profiling without UV is preferred.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Predicts ADMET properties using ADMETlab 3.0 (119 platform features, including 77 prediction models with modeled-endpoint uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Apply modern Swift language patterns and idioms for non-concurrency, non-SwiftUI code. Covers if/switch expressions (Swift 5.9+), typed throws (Swift 6+), result builders, property wrappers, opaque and existential types (some vs any), guard patterns, Never type, Regex builders (Swift 5.7+), basic Codable shaping (CodingKeys, custom decoding, nested containers), modern collection APIs (count(where:), contains(where:), replacing()), basic FormatStyle usage, and string interpolation patterns. Use when writing core Swift code involving generics, protocols, enums, closures, or modern language features; route deep Codable to swift-codable, detailed formatting/localization to swift-formatstyle, and API naming to swift-api-design-guidelines.

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Implement Swift Codable models for JSON and property-list encoding and decoding with JSONDecoder, JSONEncoder, CodingKeys, and custom init(from:) or encode(to:). Use when parsing API responses, remapping keys, flattening nested JSON, handling date or data decoding strategies, decoding heterogeneous arrays, or integrating Codable with URLSession, SwiftData, or UserDefaults.

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Guides Stripe integration decisions across development and test environment planning (separate sandboxes vs the shared test mode sandbox), API selection (Checkout Sessions vs PaymentIntents), Connect platform setup (Accounts v2, controller properties), billing/subscriptions, tax and registrations (Stripe Tax, automatic_tax, product tax codes), Treasury financial accounts, integration options (Checkout, Payment Element), migrating from deprecated Stripe APIs, and security best practices (API key management, API key permissions, webhooks, OAuth). Use when planning, building, modifying, testing, or reviewing any Stripe integration, including choosing a development environment, accepting payments, building marketplaces, integrating Stripe, processing payments, setting up subscriptions, collecting sales tax, VAT, or GST, creating connected accounts, or implementing secure key handling.

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