Write an MVP technical design from agreed requirements, including architecture choices and relevant tradeoffs.
日本語の概要は準備中です。原文の説明を表示しています。
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Write an MVP technical design from agreed requirements, including architecture choices and relevant tradeoffs.
日本語の概要は準備中です。原文の説明を表示しています。
Production-tested setup for Tailwind CSS v4 with shadcn/ui, Vite, and React. Use when: initializing React projects with Tailwind v4, setting up shadcn/ui, implementing dark mode, debugging CSS variable issues, fixing theme switching, migrating from Tailwind v3, or encountering color/theming problems. Covers: @theme inline pattern, CSS variable architecture, dark mode with ThemeProvider, component composition, vite.config setup, common v4 gotchas, and production-tested patterns. Keywords: Tailwind v4, shadcn/ui, @tailwindcss/vite, @theme inline, dark mode, CSS variables, hsl() wrapper, components.json, React theming, theme switching, colors not working, variables broken, theme not applying, @plugin directive, typography plugin, forms plugin, prose class, @tailwindcss/typography, @tailwindcss/forms
日本語の概要は準備中です。原文の説明を表示しています。
Build MCP servers for Copilot Chat using the OpenAI Apps SDK or MCP Apps SDK widget rendering support (any language). Use this skill when: - Creating MCP servers that integrate with M365 Copilot declarative agents - Building rich interactive widgets (React + Fluent UI) that render in Copilot Chat - Implementing tools that return structuredContent for widget rendering - Adapting an existing MCP server to support Copilot widget rendering - Setting up devtunnels for localhost MCP server exposure - Configuring mcpPlugin.json manifests with RemoteMCPServer runtime Do NOT use this skill for general agent development (scaffolding, manifests, deployment) — use declarative-agent-developer instead. This skill is ONLY for MCP server + widget development. Triggers: "MCP server for Copilot", "OpenAI Apps SDK", "Copilot widget", "structuredContent", "MCP plugin", "devtunnels MCP", "OAI app", "widget rendering", "UI widget"
日本語の概要は準備中です。原文の説明を表示しています。
Build dark-themed React applications using Tailwind CSS with custom theming, glassmorphism effects, and Framer Motion animations. Use when creating dashboards, admin panels, or data-rich interfaces with a refined dark aesthetic.
日本語の概要は準備中です。原文の説明を表示しています。
Review and create distinctive, production-grade frontend interfaces with high design quality and design system compliance. Evaluates using three pillars: frictionless insight-to-action, quality craft, and trustworthy building. USE FOR: PR reviews, design reviews, accessibility audits, design system compliance checks, creative frontend design, UI code review, component reviews, responsive design checks, theme testing, and creating memorable UI. DO NOT USE FOR: Backend API reviews, database schema reviews, infrastructure or DevOps work, pure business logic without UI, or non-frontend code.
日本語の概要は準備中です。原文の説明を表示しています。
Create or update AgentSkills. Use when designing, structuring, or packaging skills with scripts, references, and assets.
日本語の概要は準備中です。原文の説明を表示しています。
Predict B-cell and T-cell epitopes using BepiPred, IEDB tools, and structure-based methods for vaccine and antibody design. Identify immunogenic regions in antigens. Use when designing vaccines, mapping antibody binding sites, or predicting immunogenic peptides.
日本語の概要は準備中です。原文の説明を表示しています。
Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences. Use when predicting MHC binding for vaccine design or neoantigen identification.
日本語の概要は準備中です。原文の説明を表示しています。
Score and prioritize neoantigens and epitopes for immunogenicity using multi-factor models combining MHC binding, processing, expression, and sequence features. Rank candidates for vaccine design. Use when prioritizing epitopes for vaccine development or identifying the most immunogenic neoantigens.
日本語の概要は準備中です。原文の説明を表示しています。
Design homology-directed repair donor templates for CRISPR knock-ins using primer3-py. Create ssODN, dsDNA, or plasmid templates with optimized homology arms. Use when designing donor templates for precise insertions, tagging, or allele replacement.
日本語の概要は準備中です。原文の説明を表示しています。
CRISPR library design for genetic screens. Covers sgRNA selection, library composition, control design, and oligo ordering. Use when designing custom sgRNA libraries for knockout, activation, or interference screens.
日本語の概要は準備中です。原文の説明を表示しています。
Design pegRNAs for prime editing using PrimeDesign algorithms. Generate spacer, PBS, and RT template sequences for precise genomic modifications without double-strand breaks. Use when designing prime editing experiments for precise insertions, deletions, or point mutations.
日本語の概要は準備中です。原文の説明を表示しています。
Design guide RNAs for CRISPR-Cas9/Cas12a experiments using CRISPRscan and local scoring algorithms. Score guides for on-target activity using Rule Set 2 and Azimuth models. Use when designing sgRNAs for gene knockout, activation, or repression experiments.
日本語の概要は準備中です。原文の説明を表示しています。
Design guides for cytosine and adenine base editing using editing window optimization and BE-Hive outcome prediction. Select optimal positions for C-to-T or A-to-G conversions without double-strand breaks. Use when designing base editor experiments for precise nucleotide changes.
日本語の概要は準備中です。原文の説明を表示しています。
Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
日本語の概要は準備中です。原文の説明を表示しています。
Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
日本語の概要は準備中です。原文の説明を表示しています。
Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.
日本語の概要は準備中です。原文の説明を表示しています。
Apply Vaughn Vernon-inspired lightweight DDD rules when using bounded contexts, subdomains, context maps, and tactical modeling without excess ceremony.
日本語の概要は準備中です。原文の説明を表示しています。
Apply Vaughn Vernon-inspired implementation DDD rules when building aggregates, domain events, repositories, application services, or context integrations.
日本語の概要は準備中です。原文の説明を表示しています。
Apply John Ousterhout-inspired software design rules when reducing complexity, designing module boundaries, or reviewing APIs and abstractions.
日本語の概要は準備中です。原文の説明を表示しています。
Apply Eric Evans-inspired DDD rules when modeling a complex domain, defining bounded contexts, protecting ubiquitous language, or designing aggregates.
日本語の概要は準備中です。原文の説明を表示しています。
Detect backtest iteration stagnation and generate structurally different strategy pivot proposals when parameter tuning reaches a local optimum.
日本語の概要は準備中です。原文の説明を表示しています。
Design new Claude skills from structured idea specifications. Use when the skill auto-generation pipeline needs to produce a Claude CLI prompt that creates a complete skill directory (SKILL.md, references, scripts, tests) following repository conventions.
日本語の概要は準備中です。原文の説明を表示しています。