「deep」の検索結果

Systematically trace bugs backward through call stack to find original trigger. Use when errors occur deep in execution and you need to trace back to find the original trigger.

日本語の概要は準備中です。原文の説明を表示しています。

Validate at every layer data passes through to make bugs impossible. Use when invalid data causes failures deep in execution, requiring validation at multiple system layers.

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Provider-neutral deep-research orchestration for brainstorming, technology choices, comparisons, and state-of-the-art surveys. The Research Lead makes scope and decision calls while native subagents scout, search, verify, synthesize, audit, write, and commit every research artifact.

日本語の概要は準備中です。原文の説明を表示しています。

Explore a codebase to find opportunities for architectural improvement, focusing on making the codebase more testable by deepening shallow modules. Use when user wants to improve architecture, find refactoring opportunities, consolidate tightly-coupled modules, or make a codebase more AI-navigable.

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Idiomatic Go - package and interface design, error wrapping, table-driven tests, generics, the modern standard library (slices/maps/cmp/errors.Join), current syntax, and logging discipline. Use when writing, reviewing, or refactoring any Go code, especially code drifting toward Java/Spring shapes (deep layer trees, generic repositories, heavy frameworks) - even if the user never says "idiomatic". Distilled from spf13/go-skills and adapted to this repo.

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WOZCODE utilities. Subcommands — login, logout, status, settings, update, share, review (deep multi-persona code review), benchmark (WOZCODE vs vanilla comparison). Invoke as `/woz <subcommand>`, e.g. `/woz login` or `/woz review`.

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Think and work like an expert Genomicist. Use when a task calls for Genomicist judgment. Reasons from reference-relative coordinates, haplotypes, variant classes, and sequencing-as-measurement through GATK/DeepVariant, VEP/ClinVar/gnomAD, GIAB/hap.py benchmarking, and ACMG/AMP-ClinGen frameworks while treating build mismatches, paralog/pseudogene and GC dropout artifacts, contamination and index hopping, batch effects, and annotation drift as first-class failure modes.

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Think and work like an expert Behavioral Neuroscientist. Use when a task calls for Behavioral Neuroscientist judgment. Reasons from contingency structure, deprivation state, and latent arousal/motivation variables through Morris water maze, contextual/cued fear conditioning, operant schedules on Med Associates rigs, and DeepLabCut/SLEAP/SimBA tracking validated against ethograms, while treating thigmotaxis-as-anxiety, locomotor confounds of memory deficits, peripheral CNO sedation, and trials-as-n pseudoreplication as first-class failure modes.

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Direct production with Google DeepMind's Veo video-generation family across the Gemini Developer API and Google Cloud Gemini Enterprise Agent Platform (formerly Vertex AI). Use for Veo route and model selection, text/image/reference/first-last-frame/extension workflows, native-audio prompting, camera direction, async API operation, troubleshooting, QA, and responsible commercial content production.

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Research any topic in exhaustive depth by combining web search, academic papers, social discussions, and community conversations. Produces comprehensive briefings with evidence from every available source type, confidence scoring, and identified knowledge gaps.

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Advanced web search, content extraction, and site mapping through Tavily via SandBase. Use when asked for web research, URL content extraction, full article reading, news search, or site structure discovery.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Data-independent acquisition (DIA) proteomics analysis with DIA-NN and other tools. Use when analyzing DIA mass spectrometry data with library-free or library-based workflows for deep proteome profiling.

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Cell segmentation from multiplexed tissue images. Covers deep learning (Cellpose, Mesmer) and classical approaches for nuclear and whole-cell segmentation. Use when extracting single-cell data from IMC or MIBI images after preprocessing.

日本語の概要は準備中です。原文の説明を表示しています。

Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Run Bayesian phylogenetic analysis with MrBayes, BEAST2, RevBayes, and PhyloBayes including MCMC convergence diagnostics and model comparison. Use when needing posterior probability support, Bayesian model averaging, site-heterogeneous models for deep phylogenies, or formal model comparison via stepping-stone sampling.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Produce an intensive, cited analytical report: executive summary, multi-angle findings, contrarian views, open questions, and full sources. Use only when the user needs rigorous synthesis of a complex topic (scientific, technical, policy, or market-analytical) that cannot be answered with a short search, and wants a formal written report, not a recommendation list. Do not use for product picks, top-N lists, quick lookups, or routine "find out about X" tasks. If the request does not clearly need this kind of report, do not use this skill. Do not use for a literature review over published papers. This skill collects evidence from the open web. A request for the literature on a biomedical, clinical, life-science, or other scientific topic — papers, studies, trials, preprints — belongs to firecrawl-research-papers, which queries Firecrawl's paper index (PubMed, bioRxiv, medRxiv, arXiv) instead of searching websites.

日本語の概要は準備中です。原文の説明を表示しています。

Scan a codebase for deepening opportunities, present them as a report — HTML on request — then grill through whichever one you pick.

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Write production-grade Playwright tests in TypeScript: Page Object Model, fixtures, auto-waiting, user-facing locators, parallel execution, CI integration, sharding, and 2025-2026 feature awareness. Includes an explicit "do not" list for AI agents. Use when: "Playwright," "write E2E test," "page object," "new Playwright suite," "Playwright config." Not for: fixing one flaky test at runtime — use test-reliability. Not for: bulk regenerating selectors after a UI refactor — use selector-drift-recovery. Not for: visual baseline creation/management — use visual-testing. Not for: deep WCAG/axe audits — use accessibility-testing. Related: visual-testing, ci-cd-integration, api-testing, test-reliability, selector-drift-recovery, accessibility-testing.

日本語の概要は準備中です。原文の説明を表示しています。