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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Best practices for Remotion - Video creation in React

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Best practices for Remotion - Video creation in React

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Test native, React Native, hybrid, and Flutter mobile apps with Appium 3.x, Detox, Maestro, and Patrol. Covers device farm setup (BrowserStack, Sauce Labs), gesture simulation, deep link and cold-start testing, push notifications, biometric (Face ID) auth, offline/poor-network simulation, and iOS/Android permission dialog handling. Use when: "mobile test," "Appium," "Detox," "Maestro," "Patrol," "Flutter test," "iOS test," "Android test," "device farm," "deep link," "biometric," "Face ID," "permission dialog," "React Native test." Not for: device/browser matrix strategy in the abstract — use cross-browser-testing; app startup/memory/battery profiling depth — use performance-testing; mobile screenshot diffing — use visual-testing. Related: ci-cd-integration, cross-browser-testing, performance-testing, test-data-management, test-reliability.

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Wire dependency-cruiser into a TypeScript repo so each package is a deep module, with implementation hidden in subfolders and reachable only through its entry-point files. User-invoked.

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Teach the user a new skill or concept, within this workspace.

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Symfony UX Map for interactive maps with Leaflet or Google Maps in Symfony. Covers markers, polygons, polylines, circles, info windows, and LiveComponent integration. Use when displaying maps, placing markers, drawing shapes or routes, handling map events, building store locators, using custom tile layers, or making maps reactive with LiveComponent. Code triggers: <twig:ux:map />, Map(), Point(), Marker(), Polygon(), Polyline(), Circle(), InfoWindow(), MapOptionsInterface, ComponentWithMapTrait, fitBoundsToMarkers, ux:map:marker:before-create, ux:map:connect, SYMFONY_UX_MAP_DSN. Also trigger when the user asks "how to display a map", "how to add markers", "how to draw a polygon on a map", "how to handle map click events", "how to make a reactive map", "how to use Leaflet in Symfony", "how to use Google Maps in Symfony", "map not showing", "map has zero height". Do NOT trigger for SVG icons (use ux-icons) or general frontend interactivity (use stimulus).

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Audit the knowledge/ base and the .claude/ skills, agents and workflows for staleness, self-contradiction, and drift from their own stated rules — four independent adversarial auditors (two lenses over two trees) verify every load-bearing claim against the current tree, cross-examine each other within their tree, and reach a consensus on if/what needs changing. Use periodically, after a run of deliveries that changed build config, target layout or the skills themselves, or whenever you suspect the docs have aged out of true.

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Explain a body of work plainly so a person actually understands it. Runs the `how` and `why` skills and weaves what they find into one clear explanation. Use for 'teach me this', 'help me really understand X', 'explain this change or subsystem to me'.

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Best practices for Remotion - Video creation in React

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Apply when debugging. Trace each symptom to its root cause and fix it there; reproduce first, ask why until you reach it, resist nil-check guards that silence crashes.

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Apply to multi-step work (sweeps, migrations, runs of similar edits) and to how you stack commits and PRs. Break work into small units that each end in a verifiable state, check each before the next, and order delivery so the sequence proves itself to a reviewer.

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Draft professional emails for various business scenarios with appropriate tone and structure. Use when a user asks to write an email, compose a message, draft a reply, write a follow-up, create an outreach email, respond to a client, write a cold email, or craft any professional correspondence.

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Expert guidance for Excalidraw, the open-source virtual whiteboard library for creating hand-drawn style diagrams and sketches. Helps developers embed Excalidraw in React applications, build custom integrations, and leverage the API for programmatic diagram creation.

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Conform is a React form validation library that progressively enhances native HTML forms: it validates FormData against a Zod, Valibot or Yup schema on the server and, optionally, on the client, so a form works before JavaScript loads. Use when a user asks to build a form with Conform, validate a Next.js Server Action or a React Router / Remix action, share one schema between client and server, add or remove rows in a field list, or move to Conform's future API.

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Clerk is a hosted authentication and user-management service with drop-in UI components, social login, email/password, organizations, RBAC and webhooks. Use when adding sign-in to Next.js, React, or Express apps, protecting routes with clerkMiddleware, setting up multi-tenant organizations and roles, or syncing Clerk users to your own database.

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You are an expert in Apollo Client, the comprehensive GraphQL client for React applications. You help developers fetch data with GraphQL queries and mutations, manage local and remote state with Apollo's normalized cache, implement optimistic UI updates, handle pagination, and configure authentication — providing a complete data management solution for GraphQL-powered apps.

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Ant Design (antd) is a React component library of 70+ enterprise UI components (tables, forms, date pickers, modals, menus) with design-token theming through ConfigProvider. Use it to build admin panels, back-office tools and data-heavy dashboards: server-paginated tables with filters and bulk actions, validated forms, dark or branded themes, and antd inside Next.js without a flash of unstyled content. Triggers: "antd table", "Ant Design form validation", "customize antd theme", "antd dark mode", "antd with Next.js App Router", "upgrade antd 5 to 6".

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Alpine.js is a lightweight JavaScript framework for adding interactivity to HTML markup. It provides reactive data, event handling, and DOM manipulation through HTML attributes — like a modern jQuery replacement with declarative syntax.

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You are an expert in the Vercel AI SDK, the TypeScript toolkit for building AI-powered applications. You help developers integrate LLMs (OpenAI, Anthropic, Google, Mistral, Ollama) with React Server Components, streaming UI, tool calling, structured output with Zod schemas, RAG pipelines, multi-step agents, and edge-compatible AI features — the standard way to add AI to Next.js, Nuxt, SvelteKit, and any Node.js app.

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Expert at building multi-language applications. Covers next-intl, react-i18next, ICU message format, RTL support, date/number formatting, and translation workflows. Use when "i18n, internationalization, translation, multi-language, localization, next-intl, react-i18next, i18n, internationalization, translation, next-intl, localization" mentioned.

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Expert in LangGraph - the production-grade framework for building stateful, multi-actor AI applications. Covers graph construction, state management, cycles and branches, persistence with checkpointers, human-in-the-loop patterns, and the ReAct agent pattern. Used in production at LinkedIn, Uber, and 400+ companies. This is LangChain's recommended approach for building agents. Use when "langgraph, langchain agent, stateful agent, agent graph, react agent, agent workflow, multi-step agent, langgraph, langchain, agents, state-machine, workflow, graph, ai-agents, orchestration" mentioned.

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Expert in course platform selection and implementation - comparing Teachable, Kajabi, Thinkific, and custom solutions. Covers LMS selection criteria, platform migrations, tech stack decisions, and building vs buying. Use when "course platform, lms, teachable, kajabi, thinkific, course hosting, learning management system, which platform, " mentioned.

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Expert in building 3D experiences for the web - Three.js, React Three Fiber, Spline, WebGL, and interactive 3D scenes. Covers product configurators, 3D portfolios, immersive websites, and bringing depth to web experiences. Use when "3D website, three.js, WebGL, react three fiber, 3D experience, spline, product configurator, " mentioned.

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