「esi」の検索結果

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Master REST and GraphQL API design principles to build intuitive, scalable, and maintainable APIs that delight developers. Use when designing new APIs, reviewing API specifications, or establishing API design standards.

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Generate novel UI from a text prompt via Stitch AI; exports Tailwind/HTML + DESIGN.md for mk:frontend-design handoff. NOT implementing existing designs -- use mk:figma or mk:frontend-design.

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Generate a grounded Human Design BodyGraph and whole-chart reading from exact birth data. Use for Human Design charts, BodyGraph, decisions, profile, channels, talents, work, wealth, relationships, mission, or chart-based follow-up questions. Supports Chinese and English.

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人类图 (Human Design) 全盘解读技能。根据出生日期、准确时间和出生地点生成 BodyGraph，并以用户语言综合解读类型、策略、权威、人生角色、身体、天赋、财富、关系与使命；支持基于真实盘面的连续问答。触发词: 人类图, Human Design, BodyGraph, 人类图排盘, 人类图解读, 天赋, 使命, 职业, 关系, 类型, 策略, 权威, 人生角色, 通道, 闸门.

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Use this skill for ANY of the following — do not skip it even if the query seems simple: strategic decisions, business analysis, thesis building, complex problem solving, geopolitical analysis (non-market), philosophical reasoning, academic research, system design, decision under uncertainty, long-form thinking, or any question that benefits from First Principle deconstruction and multi-agent reasoning. ALWAYS use this skill when the user asks about: why something works the way it does, whether a decision is correct, how to think about a complex problem, what could go wrong, analyzing a situation from multiple angles, or any "should I..." question involving real-world trade-offs. This is NOT a market/trading skill — for financial markets, BTC, gold, stocks, forex, macro economics, use money-atlas-intelligence-os instead.

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Turn a reference image or mockup into a working local frontend that matches it closely. Inspects the image, extracts the design system (layout, type, spacing, color, components), implements it, then screenshot-compares and iterates to close the gap. Use when the user says "image to code", "build this mockup", "code this screenshot", "make this design real", or provides a UI image to implement. Part of the Product Design set. Uses a browser tool for screenshot verification.

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Reviews page hierarchy, grouping, density, actions and state design using consumer-owned product and design-system guidance. Use when asked for a visual design review, page critique or whether a new page communicates its task clearly.

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Select the right pharmacologic agent for a child aged 12+ with obesity using the CMAJ 2025 guideline — choosing between GLP-1 receptor agonists, metformin, or orlistat with monitoring guidance. Trigger when a clinician asks which medication to use for pediatric obesity, whether to start semaglutide or metformin in a child, or how to manage obesity pharmacologically in adolescents.

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Generate multiple radically different interface designs for a module using parallel sub-agents. Use when user wants to design an API, explore interface options, compare module shapes, or mentions "design it twice".

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54 real design systems (Stripe, Linear, Vercel) as HTML/CSS.

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Comprehensive REST API design review with automated linting, breaking-change detection, and design scorecards. Catches inconsistent conventions, missing versioning, and design smells before APIs ship. Use when reviewing a PR that adds or changes API endpoints, auditing an existing API for v2 migration, or establishing API standards for a team.

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Practical UI refactoring and visual design review inspired by Refactoring UI by Steve Schoger and Adam Wathan. Use when an AI coding agent needs to improve an existing interface, audit visual polish, redesign a rough UI, review frontend code for hierarchy/spacing/typography/color/depth/image issues, or turn a plain implementation into a cleaner product-quality screen. Do not use for creating UI from scratch, scaffolding a new app, building a new landing page, or designing a new design system unless the user explicitly asks to review or refactor an existing interface.

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Expert-level chemical process design covering process flow diagrams, mass and energy balances, equipment sizing, economic evaluation, and sustainable process design.

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Expert-level spacecraft design covering mission analysis, subsystem design, power and thermal management, attitude control, communications, and systems engineering.

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Expert-level transportation engineering covering highway design, traffic flow, intersection design, pavement design, traffic impact studies, and public transit.

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Expert-level CAD design covering parametric modeling, assembly design, drawing creation, FEA simulation, design for manufacturing, and PLM workflows.

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Expert-level developmental biology covering embryogenesis, cell fate determination, morphogen gradients, organogenesis, stem cells, and regenerative medicine.

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Generate beautiful, on-brand HTML artifacts — reports, diagrams, diff reviews, slide decks, plans, recaps, dashboards. Loads on creation intents ("create a plan", "make me an implementation plan", "generate a diagram", "build a slide deck", "draft a recap", "visualize this", "render this as HTML", "make me a status update") and exploration intents ("show me three layouts", "explore document shapes", "compare visual treatments", "explore a new design system", "compare replacement brand directions") and iteration intents ("make this beautiful", "polish this report", "make this less generic", "design this", "theme this", "use my brand", "iterate on this design", "review this artifact", "make this bolder", "make this quieter", "simplify this design", "animate this", "improve the look of", "give this a refresh"). Captures brand from the user's codebase, asking, or live site, then applies it to every artifact.

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Grounded design brief from the corpus — style, WCAG color tokens, typography, layout, anti-patterns. Use on ui-design-brief or any which-style/palette/font/chart call; feeds fe-design.

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