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概要と使いどころ
Query RegulomeDB v2 GET REST API to score variants for regulatory function and retrieve overlapping evidence (TF binding, histone marks, DNase peaks, footprints, motifs, eQTLs, chromatin state). Scores range 1a (strongest) to 7 (none). Use for GWAS hit prioritization, regulatory variant annotation, cis-regulatory discovery. Use clinvar-database for pathogenicity; gwas-database for trait associations.
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Query the ClinPGx (formerly PharmGKB) REST API plus the CPIC PostgREST companion API for pharmacogenomic clinical annotations, CPIC/DPWG dosing guidelines, gene-drug pairs, variant-drug associations, FDA/EMA drug labels, and PGx pathways. Two-host architecture: api.clinpgx.org for annotation records, api.cpicpgx.org for genotype→recommendation lookups. No auth. For germline pathogenicity use clinvar-database; for somatic cancer PGx use cosmic-database or opentargets-database; for drug bioactivity use chembl-database-bioactivity.
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ENCODE Portal REST API for regulatory genomics: TF ChIP-seq, ATAC-seq/DNase-seq peaks, histone marks, and RNA-seq across 1000+ cell types. Search experiments by assay/biosample/target; download BED/bigWig; retrieve SCREEN cCREs by region or gene. Use to annotate variants with regulatory tracks, find open chromatin in a cell type, or fetch peak files for ChIP/ATAC analysis. For regulatory variant scoring use regulomedb-database; for GWAS associations use gwas-database.
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Monarch Initiative knowledge graph REST API for disease-gene-phenotype associations and cross-species orthology. MONDO disease-to-gene/phenotype, HP phenotype profiles, cross-species comparisons. Use for rare disease gene prioritization and phenotype-based candidate ranking. For GWAS use gwas-database; for clinical pathogenicity use clinvar-database.
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Query NCBI ClinVar via E-utilities for variant clinical significance, pathogenicity, disease associations. Search by gene/rsID/condition/review status; returns ClinSig, submitter data, conditions, HGVS. For GWAS use gwas-database; for variant consequence prediction use Ensembl VEP.
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Query Open Targets GraphQL API for target-disease associations, evidence, drug links, safety. Search targets by gene, diseases by EFO ID; scores from 20+ sources, drug mechanisms, tractability. For ChEMBL use chembl-database-bioactivity; for trials use clinicaltrials-database-search.
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PyTorch Geometric (PyG) for graph neural networks: node/graph classification, link prediction with GCN, GAT, GraphSAGE, GIN. Message passing, mini-batches, heterogeneous graphs, neighbor sampling, explainability. Supports molecules (QM9, MoleculeNet), social/knowledge graphs, 3D point clouds. For non-graph DL use PyTorch; for classical graph algorithms use NetworkX.
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把一句话需求转成可复现、可验收视频工程的乔木智能剪辑导演。Use when the user asks to create, plan, edit, remix, explain, narrate, subtitle, animate, composite, or render a video—including one-line requests such as “制作一个科普视频：介绍 LLM 中的 RL”. Builds English-learning movie mixes, person profiles, explainers, code-drawn motion graphics (UI morph loops, showreels, kinetic-type promos, line-art/pixel/Three.js animation, lyric MVs), product launch videos, cinematic shorts, social clips, course/PPT videos, AI image/video/TTS/music-assisted stories, stock-footage stories, or multi-source montage. Routes across 33台词, ClipSeek/open media, local files, ListenHub, image generation, HTML/SVG/Canvas motion graphics with beat-grid storyboards and determinism probes, Manim, ffmpeg-full, captions, sound design, frame-0 video covers with YouTube thumbnails, and release checks.
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Map how customers discover, evaluate, and choose a product across Google, AI chatbots (ChatGPT, Claude, Perplexity), and social platforms, using the 5-stage awareness journey. Use when the user asks about search intent, AI SEO prompts, discoverability, buyer journeys, awareness stages, or what content to create for a brand, website, or keyword list.
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Get the transcript, on-screen text, summary, and chapters of any video or audio with Scribiz. Use when the user wants to transcribe a YouTube, TikTok, Instagram, podcast, or local media file, generate SRT or VTT subtitles, summarize a video, ask questions about a video, or turn a video into a blog post, show notes, or social posts.
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Provides Better Auth integration patterns for NestJS backend and Next.js frontend with Drizzle ORM and PostgreSQL. Use when setting up Better Auth with NestJS backend, integrating Next.js App Router frontend, configuring Drizzle ORM schema, implementing social login (GitHub, Google), adding plugins (2FA, Organization, SSO, Magic Link, Passkey), implementing email/password authentication with session management, or creating protected routes and middleware.
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Posts review findings from a JSON file as inline comments on a GitHub Pull Request, attaching each comment to its file and line. Use when you have a list/JSON of review findings (each with a file path, line number, and a message such as summary/failure_scenario) and want them published on a PR as inline review comments. Triggers include "post these review comments on the PR", "associate comments to files in the PR", "publish review findings to PR
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Generates properly tagged UTM links with consistent naming conventions. Maintains a UTM registry file (utm-registry.json) to enforce naming consistency, prevent duplicates, generate short links, and output ready-to-copy links for LinkedIn, email, social, and ads.
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Transform webinar recordings into multiple content assets including blog post series, social media snippets, infographic ideas, email sequences, and sales one-pagers. Extracts key moments, quotes, and insights for maximum content ROI. Use when users need to repurpose webinars, video content, or live presentations into multi-channel marketing materials.
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Convert webinar recordings into blog posts, social snippets, email series. Extract key quotes, statistics, and soundbites.
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Transform podcast transcripts into comprehensive content marketing suites including blog posts, social media content, newsletters, SEO-optimized articles, and timestamps. Use when user provides podcast transcripts or wants to repurpose podcast content.
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Aggregate prospect intelligence from multiple sources including news, social media, company websites, and financial data.
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Turn real customer reviews, quotes, and case-study results into polished social-proof videos built in HyperFrames -- single-testimonial spotlights, review-wall montages, and stat-driven proof reels with captions and voiceover, cut for vertical, square, and wide. The highest-converting content most businesses never make.
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Writes conversion-focused landing page copy - headlines, subheads, value propositions, feature and benefit blocks, social proof, FAQs, and CTA button text - using PAS, AIDA, or StoryBrand. Use when the user wants words for a landing page, sales page, product or pricing page, waitlist page, homepage hero, or ad-to-page flow, including rewriting weak copy, generating headline or CTA variants for A/B tests, or turning a product description into page sections. Use landing-page-optimizer instead for auditing an existing page's performance, and a frontend skill for building the page itself.
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Turn a marketing brief or product offer into a finished short-form video ad built in HyperFrames — hook, script, shot-by-shot storyboard, scene-by-scene HTML composition, captions, and voiceover. Outputs platform cuts (vertical 9:16, square, 16:9). Use when you need a launch ad, product promo, social video, or paid-creative concept ready to render.
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Analyze matchups, injuries, weather, Vegas lines. Recommend sit/start decisions with confidence levels for NFL, NBA, MLB, NHL, soccer.
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Cleans up CRM data from HubSpot, Salesforce, Pipedrive, Zoho, Close, Attio, or any CRM CSV export. Finds duplicate contacts and companies with fuzzy matching (not just exact email), normalizes emails, phones to E.164, names, domains, states, and countries, flags stale, invalid, role, and test records, finds broken contact-company associations, and produces a reviewable merge plan plus import-ready files without touching the live CRM. Use this skill whenever the user wants to dedupe, find or merge duplicate contacts, merge companies or accounts, clean up a CRM, prep a CRM migration or re-import, or says the CRM export is a mess. Also use it when they mention only one symptom, like "the same person is in here three times", "half our leads are junk", or "our company records don't match".
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Create brand-safe content for athletes. Personal branding strategy, engagement optimization, crisis communication, sponsor integration.
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Analyzes a company's content to extract and codify their brand voice into a comprehensive style guide. Reads website copy, blog posts, emails, and social media to identify tone, vocabulary patterns, sentence structure, personality traits, and word preferences. Generates a brand-voice-guide.md and reviews new content against it.
日本語の概要は準備中です。原文の説明を表示しています。