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Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.

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RichDocument action toolkit for markdown and interactive content outside live chat. Use when adding an action or content source, wiring a remote action surface, putting actions on a MarkdownStream/BasicMarkdownContent preview, or touching features/rich-document/**, <RichDocument>, <RichDocumentActionSurface>, registerAction, ContentSourceAdapter, or enableContextMenu. NOT for the live chat message bar (use overlay-system).

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Redux Toolkit selector rules against re-renders, recalculation warnings, and render loops. Use when writing useSelector/useAppSelector or createSelector, deriving state in a connected component, or seeing 'Selector returned a different result when called with the same parameters'.

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Toolkit for styling artifacts with curated themes (slides, docs, reports, HTML landing pages, and more). Use when you need consistent typography and color systems or want to generate a new theme on the fly.

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Route a PR review request to the correct tool — code-review plugin (quick parallel scan across all dimensions) or pr-review-toolkit (deep-dive on a specific quality dimension such as type design, error handling, test quality, comments, or simplification). Use when the user asks for a code review, PR review, or mentions a specific quality concern before creating a PR.

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Comprehensive toolkit for writing high-quality computer science research papers (conference, journal, thesis). Provides narrative construction guidance, sentence-level clarity principles (Gopen & Swan), academic phrasebank, CS-specific conventions, and section-by-section quality checklists. Use when assisting with academic paper writing, revision, or structure planning across all stages from drafting to submission.

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Toolkit for creating an entertainingly stupid README that manages to give off Tim & Eric, Steve Brule vibes while maintaining a level of technical acumen that is expected of a modern open source project. This skill applies when users request a silly or absurd README.

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Automate Box operations including file upload/download, content search, folder management, collaboration, metadata queries, and sign requests through Composio's Box toolkit.

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Automate Brevo (formerly Sendinblue) email marketing operations through Composio's Brevo toolkit via Rube MCP.

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Complete App Store Optimization (ASO) toolkit for researching, optimizing, and tracking mobile app performance on Apple App Store and Google Play Store

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Mandatory skills, conventions, and behavioral rules for Avalonia UI development using the Zafiro toolkit.

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6 production-ready AI engineering workflows: prompt evaluation (8-dimension scoring), context budget planning, RAG pipeline design, agent security audit (65-point checklist), eval harness building, and product sense coaching.

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Toolkit for creating animated GIFs optimized for Slack, with validators for size constraints and composable animation primitives. This skill applies when users request animated GIFs or emoji animations for Slack from descriptions like "make me a GIF for Slack of X doing Y".

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Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

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Toolkit for styling artifacts with a theme. These artifacts can be slides, docs, reportings, HTML landing pages, etc. There are 10 pre-set themes with colors/fonts that you can apply to any artifact that has been creating, or can generate a new theme on-the-fly.

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Statistical analysis toolkit. Hypothesis tests (t-test, ANOVA, chi-square), regression, correlation, Bayesian stats, power analysis, assumption checks, APA reporting, for academic research.

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Comprehensive PDF manipulation toolkit for extracting text and tables, creating new PDFs, merging/splitting documents, and handling forms. When Claude needs to fill in a PDF form or programmatically process, generate, or analyze PDF documents at scale.

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通用 REST API 工具包，用于快速接入第三方服务、调试端点和构建自动化流程。

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上层编排 Skill，通过 **Brave Search 发现 → 智能选择浏览器截图** 完成结构化素材采集。 文章素材收集编排Skill。为MediaClaw内容生产提供结构化的多平台素材采集workflow。 强制使用OpenClaw Browser截图实际文章页面，支持GitHub/Reddit/X/Medium/知乎等。 用法: (1) content-ops-toolkit素材阶段调用 (2) daily-*-content素材采集 (3) 独立素材收集任务。 Trigger: "收集素材", "素材收集", "采集素材", "素材", "找素材", "research materials", "material collect". Author: Daniel Li version: 2.1.0 dependencies: [brave-search, web-content-capture]

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Research venture capital firms, angel investors, and funding sources for startup fundraising. Use when: "投资人调研", "找VC", "research investors", "VC list", "funding sources", "investor database", "天使投资人", "venture capital", "融资对象", "投资人画像". Generates a structured investor research report with firm profiles, investment thesis, portfolio companies, contact strategies, and warm introduction paths. Part of UniqueClub founder toolkit. Learn more: https://uniqueclub.ai Pairs with pitch-deck-creator for complete fundraising preparation.

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Complete development kit for Microsoft 365 Copilot declarative agents with three comprehensive workflows (basic, advanced, validation), TypeSpec support, and Microsoft 365 Agents Toolkit integration

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Builds Uno Platform cross-platform apps. Extensions, MVUX, Toolkit controls, Hot Reload.

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Builds WPF on .NET 8+. Host builder, MVVM Toolkit, Fluent theme, performance, modern C# patterns.

日本語の概要は準備中です。原文の説明を表示しています。